经腓骨前入路在胫骨远端非骨化性纤维瘤手术中的应用研究

目的:探讨经腓骨前入路在胫骨远端非骨化性纤维瘤(non-ossifying fibroma,NOF)手术中的临床疗效。方法:回顾性分析2021年1月至2022年8月于中国医科大学附属盛京医院采用经腓骨前侧入路治疗胫骨远端NOF 19例患者的临床资料,统计手术时间及术中失血量,术后使用疼痛评分及踝关节功能评分,评价术后患肢功能。结果:19例患者均由同一位医师使用经腓骨前入路完成手术,手术时间(59.2±16.8)min,术中失血量(33.7±25.6)m L,术后疼痛视觉模拟评分(0.5±0.6)分,术后踝关节功能评分(98.4±3.7)分。结论:经腓骨前入路治疗胫骨远端NOF,操作简便、手术时长短、术中失血少,神经损伤风险低,是一种安全有效的术式。

清凉慢岛——重庆九龙半岛城市更新规划设计研究

在我国城市经历了快速城市化进程后,城市更新成为转型发展的重要途径。低碳生态和高质量发展是目前城市更新中的关键议题。“山城火炉”重庆在过去40年的快速扩张发展后,亟需探索可持续的城市更新路径。尚未更新的九龙半岛成为研究和规划设计的典型地区。本文从生态、历史、产业、社会、交通等方面分析了九龙半岛的资源禀赋,判断其具有成为中心城区凉岛绿心、建构地区级历史资源体系和成为世界级双年展场的潜力,据此提出将“清凉慢岛”作为其发展定位。规划设计围绕“清凉”和“慢”两大主题,通过“清凉生态”“低碳交通”“慢体验”“慢创作”和“慢生活”五大策略,谋划由总体规划到地段设计的更新路径,并探索实施保障。本文试图建构一种比较视野下的面向生态和经济的定性、定量分析方法,并落实到设计方案中,提出对存量地区更新的多维度解决方案。

Trisubstituted alkenes featuring aryl groups:stereoselective synthetic strategies and applications

In recent years,the synthesis and application of alkenes have attracted increased attention.Triphenylethenes(TriPEs)have lower molecular torsion than tetraphenylethenes(TPEs),which helps to balance the degree of conjugation and the aggregation-induced emission(AIE)effect.The geometry of double bonds has a significant impact on luminescence.Therefore,it is essential to provide a comprehensive summary of the stereoselective synthetic strategies for trisubstituted alkenes.In this review,common strategies for the stereoselective synthesis of alkenes are described,with an emphasis on the origin of stereoselectivity and the types of substrates.In addition,the AIE properties of TriPE and its applications in optoelectronic devices,stimuli-responsive materials,sensors,and therapies were discussed.

HYD-PEP06 suppresses hepatocellular carcinoma metastasis,epithelial-mesenchymal transition and cancer stem cell-like properties by inhibiting PI3K/AKT and WNT/β-catenin signaling activation

HYD-PEP06,an endostatin-modified polypeptide,has been shown to produce effective anticolorectal carcinoma effects through inhibiting epithelial-mesenchymal transition(EMT).However,whether HYD-PEP06 has similar suppressive effect on hepatocellular carcinoma(HCC) remained unknown.In this study,HYD-PEP06 inhibited metastasis and EMT but not proliferation in vitro.Cignal finder pathway reporter array and Western blot analysis revealed that HYD-PEP06 suppressed HCCLM3 cell metastasis and EMT by inhibiting the PI3 K/AKT pathway.Moreover,HYD-PEP06 exerted antimetastasis effects in HepG2 cancer stem-like cells(CSCs) via suppressing the WNT/β-catenin signaling pathway.Finally,in HCCLM3 tumor-bearing BALB/c nu/nu nude mice,HYD-PEP06 substantially suppressed tumor growth,lung metastasis and HCC progress.Our results suggest that HYD-PEP06 inhibits the metastasis and EMT of HCC and CSCs as well,and thus has the potential as an agent for HCC treatment.

High peak power femtosecond cylindrical vector beams generation in a chirped-pulse amplification laser system

Cylindrical vector beams(CVBs),with non-uniform state of polarizations,have become an indispensable tool in many areas of science and technology.However,little research has explored high power CVBs at the femtosecond regime.In this paper,we report on tne generation of high quality CVBs with high peak power and femtosecond pulse duration in a fiber chirped-pulse amplification laser system.The radially(azimuthally)polarized vector beam has been obtained with a pulse duration of 4A0 fs[430 fs]and a maximum average output power of 20.36 W[20.12 W].The maximum output pulse energy is〜20μJ at a repetition rate of 1 MHz,corresponding to a high peak power of-46 MW.The comparison between simulated intensity profiles and measured experimental results suggests that the generated CVBs have a remarkable intensity distribution.The proposed configuration of our laser system provides a promising solution for high quality CVBs generation with the characteristics of high peak power,ultrashort pulse duration,and high mode purity.

Large language models for human–robot interaction:A review

The fusion of large language models and robotic systems has introduced a transformative paradigm in human–robot interaction,offering unparalleled capabilities in natural language understanding and task execution.This review paper offers a comprehensive analysis of this nascent but rapidly evolving domain,spotlighting the recent advances of Large Language Models(LLMs)in enhancing their structures and performances,particularly in terms of multimodal input handling,high-level reasoning,and plan generation.Moreover,it probes the current methodologies that integrate LLMs into robotic systems for complex task completion,from traditional probabilistic models to the utilization of value functions and metrics for optimal decision-making.Despite these advancements,the paper also reveals the formidable challenges that confront the field,such as contextual understanding,data privacy and ethical considerations.To our best knowledge,this is the first study to comprehensively analyze the advances and considerations of LLMs in Human–Robot Interaction(HRI)based on recent progress,which provides potential avenues for further research.

Presence of Rare Variants is Associated with Poorer Survival in Chinese Patients with Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis(ALS)is a fatal neurodegenerative disorder with phenotypic and genetic heterogeneity.Recent studies have suggested an oligogenic basis of ALS,in which the co-occurrence of two or more genetic variants has additive or synergistic deleterious effects.To assess the contribution of possible oligogenic inheritance,we profiled a panel of 43 relevant genes in 57 sporadic ALS(sALS)patients and eight familial ALS(fALS)patients from five pedigrees in east China.We filtered rare variants using the combination of the Exome Aggregation Consortium,the 1000 Genomes and the HuaBiao Project.We analyzed patients with multiple rare variants in 43 known ALS causative genes and the genotype–phenotype cor-relation.Overall,we detected 30 rare variants in 16 different genes and found that 16 of the sALS patients and all the fALS patients examined harbored at least one variant in the investigated genes,among which two sALS and four fALS patients harbored two or more variants.Of note,the sALS patients with one or more variants in ALS genes had worse survival than the patients with no variants.Typically,in one fALS pedigree with three variants,the family member with three variants(Superoxide dismutase 1(SOD1)p.V48A,Optineurin(OPTN)p.A433V and TANK binding kinase 1(TBK1)p.R573H)exhibited much more severe disease phenotype than the member carrying one variant(TBK1 p.R573H).Our findings suggest that rare variants could exert a negative prognostic effect,thereby supporting the oligogenic inheritance of ALS.

Aggregation-enabled alkene insertion into carbon–halogen bonds

Molecular aggregation affects the electronic interactions between molecules and has emerged as a powerful tool in material science.Aggregate effect finds wide applications in the research of new physical phenomena;however,its value for chemical reaction development has been far less explored.Herein,we report the development of aggregation-enabled alkene insertion into carbon–halogen bonds.The spontaneous cleavage of C–X(X=Cl,Br,or I)bonds generates an intimate ion pair,which can be quickly captured by alkenes in an aggregated state.Additional catalysts or promoters are not necessary under such circumstances,and solvent quenching experiments indicate that the aggregated state is critical for achieving such sequences.The ionic insertion mode is supported by mechanistic studies,density functional theory calculations,and symmetry-adapted perturbation theory analysis.Results also show that the non-aggregated state may quench the transition state and terminate the insertion process.

Multifunctional aramid nanofibers reinforced RGO aerogels integrated with high-efciency microwave absorption, sound absorption and heat insulation performance

Although lightweight and three-dimensional(3 D) graphene aerogels are highly desirable for microwave absorption(MA) due to their high porosity,specific surface area,and 3 D conductive network,it still remains a large challenge to construct a multifunctional application framework to quickly adapt to the complex practical environment,making it to be efficiently applied in a variety of complex situation.Herein,multifunctional aramid nanofibers(ANFs) reinforced reduced graphene oxide aerogels(RGO@ANF) have been achieved by in-situ gel reaction,freeze-drying,and thermal annealing processes.The introduced ANFs in RGO aerogels can prevent the graphene sheets from over-stacking and enhance the connectivity of cell walls,thus leading to excellent compression resistance,MA,sound absorption,and thermal insulation performance.Under 70% strain,the maximum compressive stress of RGO@ANF aerogel reaches78.8 kPa,and reversible compressibility with reliable resistance to fatigue for 100 compressive cycles at20% strain.Further,the RGO@ANF aerogel exhibit a minimum reflection loss(RL_(min)) of-56.5 dB and a maximum effective absorption bandwidth(EAB) of 7.0 GHz at a thickness of 2.8 mm,basically covering the X and Ku bands.Moreover,the hybrid aerogel exhibited excellent sound absorption with an average absorption coefficient> 0.56 at 2-6 kHz and good thermal insulation performance with low thermal conductivity of about 49.18 mW m-1K-1.The integrated graphene aerogels with such multifunctional performances hold a great promise for applications such as MA,sound absorption,and heat insulation.

High-power and high-efficiency 4.3 μm ZGP-OPO

In this paper,a high-power and high-efficiency 4.3μm mid-infrared(MIR)optical parametric oscillator(OPO)based on ZnGeP_(2)(ZGP)crystal is demonstrated.An acousto-optically Q-switched Ho Y_(3)Al_(5)O_(12) laser operating at 2.1μm with a maximum average output power of 35 W and pulse width of 38 ns at a repetition rate of 15 kHz is established and employed as the pump source.A doubly resonant OPO is designed and realized with the total MIR output power of 13.27 W,including the signal and idler output power of 2.65 W at 4.07μm and 10.62 W at 4.3μm.The corresponding total optical-to-optical and slope efficiencies are 37.9%and 67.1%,respectively.The shortest pulse width,beam quality factor,and output power instability are measured to be 36 ns,M_(x)^(2)=1.8,M_(y)^(2)=2.0,and RMS<1.9%at 8 h,respectively.Our results pave a way for designing high-power and high-efficiency 4–5μm MIR laser sources.

Heterogeneous integrated phase modulator based on two-dimensional layered materials

Silicon nitride,with ultralow propagation loss and a wide transparency window,offers an exciting platform to explore integrated photonic devices for various emerging applications.It is appealing to combine the intrinsic optical properties of two-dimensional layered materials with high-quality optical waveguides and resonators to achieve functional devices in a single chip.Here we demonstrate a micro-ring resonator-based phase modulator integrated with few-layer MoS_(2).The ionic liquid is employed directly on the surface of MoS_(2) to form a capacitor configuration.The effective index of the composite MoS_(2)–SiN waveguide can be modulated via adjusting bias voltages to achieve different charged doping induced electro-refractive responses in MoS_(2) film.The maximum effective index modulation of the composite MoS_(2)–SiN waveguide can be achieved to 0.45×10^(−3).The phase tuning efficiency is measured to be 29.42 pm/V,corresponding to a V_(π)L of 0.69 V·cm.Since the micro-ring resonator is designed near the critical coupling regime,the coupling condition between the bus waveguide and micro-ring resonator can also be engineered from under-coupling to over-coupling regime during the charged doping process.That can be involved as a degree of freedom for the coupling tailoring.The ability to modulate the effective index with two-dimensional materials and the robust nature of the heterostructure integrated phase modulator could be useful for engineering reliable ultra-compact and low-power-consumption integrated photonic devices.

Mutually testing source-device-independent quantum random number generator

Quantum random numbers have an incomparable advantage over pseudo-random numbers since randomness originates from intrinsic property of quantum mechanics.The generation rate and the security of quantum random numbers are two significant indicators of a quantum random number generator(QRNG)for practical applications.Here we propose a mutually testing source-device-independent QRNG by simultaneously measuring a pair of conjugate quadratures from two separate parts of an untrusted continuous-variable quantum state.The amounts of randomness of the quadratures can be mutually estimated by each other via entropic uncertainty principle.Instead of randomly toggling between the conjugate quadratures of one state for collecting different types of data,two quadratures can generate check data and raw bits simultaneously and continuously in this mutually testing manner,which enhances the equivalent generation rate of private random bits to around 6 Gbit/s with a 7.5 mW laser beam.Moreover,the overall security is also improved by adjusting the conditional min-entropy in real time according to the continually monitored fluctuations of the local oscillator and the randomly measured electronic noise of homodyne detectors.