One key concept of Industry 4.0 is the industrial digital twin(DT)-a virtual replica of physical assets,processes,and systems.DTs optimise operations,enhance productivity,and facilitate innovation across various indus...One key concept of Industry 4.0 is the industrial digital twin(DT)-a virtual replica of physical assets,processes,and systems.DTs optimise operations,enhance productivity,and facilitate innovation across various industries,including manufacturing,energy,healthcare,and transportation.This paper presents a multi-domain and multi-time scale modelling and simulation platform,featuring built-in model libraries that represent diverse physical,chemical,and behavioural properties.A comprehensive system model-ling approach and a closed-loop industrial control system based on DTs are developed,showcasing advanced control,optimisation,and system security research capabilities.The architecture and advantages of the novel generation modelling platform are detailed,with specific applications highlighted,underscoring its contributions to the process industry.展开更多
In this study, a xylanase-produeing Aspergillus niger strain, NS-1, was screened and isolated from agricultural and forestry wastes. Based on single-fac- tor experiments, the effects of different carbon sources, compo...In this study, a xylanase-produeing Aspergillus niger strain, NS-1, was screened and isolated from agricultural and forestry wastes. Based on single-fac- tor experiments, the effects of different carbon sources, composite carbon sources, nitrogen sources, calcium carbonate concentrations, initial pH and surfactants on xylanase production by A. niger NS-1 were investigated. The results indicated that the most appropriate carbon source was corncobs ; the best composite carbon source was corncobs + xylan, which was conducive to xylanase secretion; the most suitable nitrogen source was ammonium sulfate. Xylanase activity reached the highest in the medium added with 1.5% calcium carbonate and SDS as a surfactant with an initial pH of 5.0. This study provided the basis for the production of high-activity xylanase.展开更多
In the design of negative hydrogen ion sources,a magnetic filter field of tens of Gauss at the expansion region is essential to reduce the electron temperature,which usually results in a magnetic field of around 10 Ga...In the design of negative hydrogen ion sources,a magnetic filter field of tens of Gauss at the expansion region is essential to reduce the electron temperature,which usually results in a magnetic field of around 10 Gauss in the driver region,destabilizing the discharge.The magnetic shield technique is proposed in this work to reduce the magnetic field in the driver region and improve the discharge characteristics.In this paper,a three-dimensional fluid model is developed within COMSOL to study the influence of the magnetic shield on the generation and transport of plasmas in the negative hydrogen ion source.It is found that when the magnetic shield material is applied at the interface of the expansion region and the driver region,the electron density can be effectively increased.For instance,the maximum of the electron density is 6.7×10^(17)m^(-3)in the case without the magnetic shield,and the value increases to 9.4×10^(17)m^(-3)when the magnetic shield is introduced.展开更多
In modern data centers, because of the deadline- agnostic congestion control in transmission control protocol (TCP), many deadline-sensitive flows can not finish before their deadlines. Therefore, providing a higher...In modern data centers, because of the deadline- agnostic congestion control in transmission control protocol (TCP), many deadline-sensitive flows can not finish before their deadlines. Therefore, providing a higher deadline meeting ratio becomes a critical challenge in the typical online data intensive (OLDI) ap- plications of data center networks (DCNs). However, a problem named as priority synchronization is found in this paper, which de- creases the deadline meeting ratio badly. To solve this problem, we propose a priority probability deceleration (P2D) deadline-aware TCP. By using the novel probabilistic deceleration, p2D prevents the priority synchronization problem. Simulation results show that P2D increases the deadline meeting ratio by 20% compared with D2TCP.展开更多
Objective There are several reports that suggest a significant role played by microRNAs(miRNAs) in cell invasion, metastasis, differentiation, and apoptosis in lung cancers. miR-375 is one such miRNA that has been det...Objective There are several reports that suggest a significant role played by microRNAs(miRNAs) in cell invasion, metastasis, differentiation, and apoptosis in lung cancers. miR-375 is one such miRNA that has been detected in a variety of tumors, but its specific activity in non-small cell lung cancer(NSCLC) remains unclear. Methods In this study, we regulated the expression of miR-375, to evaluate its influence on the 14-3-3ζ/ERK/MYC pathway in NSCLC. Results The results of our experiments suggest that miR-375 and 14-3-3ζ are highly expressed in NSCLC, and the over-expression of miR-375 increases the invasive, metastatic, and proliferative ability and decreases the apoptotic ability of NSCLC cells. In addition, protein expression levels of 14-3-3ζ, p-ERK, and MYC increased following the overexpression of miR-375. Conclusion Overall, our findings indicate that miR-375 increases the malignant potential of NSCLC via the 14-3-3ζ/ERK/MYC pathway.展开更多
Let F be a graph and H be a hypergraph.We say that H contains a Berge-F If there exists a bijectionψ:E(F)→E(H)such that for Ve E E(F),e C(e),and the Turan number of Berge-F is defined to be the maximum number of edg...Let F be a graph and H be a hypergraph.We say that H contains a Berge-F If there exists a bijectionψ:E(F)→E(H)such that for Ve E E(F),e C(e),and the Turan number of Berge-F is defined to be the maximum number of edges in an r-uniform hypergraph of order n that is Berge-F-free,denoted by ex,(n,Berge-F).A linear forest is a graph whose connected components are all paths or isolated vertices.Let Ln,k be the family of all linear forests of n vertices with k edges.In this paper,Turan number of Berge-Ln,in an r-uniform hypergraph is studied.When r≥k+1 and 3≤r≤l[]=1,we determine 2 the exact value of ex,(n,Berge-Ln,)respectively.When K-1≤r≤k,we 2 determine the upper bound of ex,(n,Berge-Ln,).展开更多
This work reports the real-time observation of the interlayer lattice vibrations in bilayer and few-layer PtSe_2 by means of the coherent phonon method. The layer-breathing mode and standing wave mode of the interlaye...This work reports the real-time observation of the interlayer lattice vibrations in bilayer and few-layer PtSe_2 by means of the coherent phonon method. The layer-breathing mode and standing wave mode of the interlayer vibrations are found to coexist in such a kind of group-10 transition metal dichalcogenides(TMDCs). The interlayer breathing force constant standing for perpendicular coupling(per effective atom) is derived as 7.5 N/m,2.5 times larger than that of graphene. The interlayer shearing force constant is comparable to the interlayer breathing force constant, which indicates that PtSe2 has nearly isotropic interlayer coupling. The low-frequency Raman spectroscopy elucidates the polarization behavior of the layer-breathing mode that is assigned to have A1 g symmetry. The standing wave mode shows redshift with the increasing number of layers, which successfully determines the out-of-plane sound velocity of PtSe2 experimentally. Our results manifest that the coherent phonon method is a good tool to uncover the interlayer lattice vibrations, beyond the conventional Raman spectroscopy limit. The strong interlayer interaction in group-10 TMDCs reveals their promising potential in high-frequency(~terahertz) micro-mechanical resonators.展开更多
Selective hydrogenation of alkynes to alkenes remains challenging in the field of catalysis due to the ease of over-hydrogenated of alkynes to alkanes.Favorably,the incorporation of metal nanoparticles(MNPs)into metal...Selective hydrogenation of alkynes to alkenes remains challenging in the field of catalysis due to the ease of over-hydrogenated of alkynes to alkanes.Favorably,the incorporation of metal nanoparticles(MNPs)into metal-organic frameworks(MOFs)provides an opportunity to adjust the surface electronic properties of MNPs for selective hydrogenation of alkynes.Herein,we used differentmetal-O clusters of MOFs to regulate the electronic status of platinum nanoparticles(Pt NPs)toward overhydrogenation,semihydrogenation,and unhydrogenation of phenylacetylene.Specifically,Pt/Fe-O cluster-based MOFs are found to reduce the electronic density on Pt NPs and inhibit the overhydrogenation of styrene,leading to an 80%increase in selectivity toward a semihydrogenation product(styrene).Meanwhile,Cu-O cluster-based MOFs generate high oxidation states of Pt NPs and release Cu^(2+)ions,which worked together to deactivate Pt NPs in the hydrogenation reaction entirely.Thus,our studies illustrate the critical role of metal-O clusters in governing chemical environments within MOFs for the precise control of selective hydrogenation of alkynes,thereby,offering appealing opportunities for designing MNPs/MOFs catalysts to prompt a variety of reactions.展开更多
A triple-objective optimal design method for AC filters in high voltage direct current(HVDC)system based on an improved multi-objective evolutionary algorithm based on decomposition(MOEA/D)is proposed.A triple-objecti...A triple-objective optimal design method for AC filters in high voltage direct current(HVDC)system based on an improved multi-objective evolutionary algorithm based on decomposition(MOEA/D)is proposed.A triple-objective optimisation mathematical model including total harmonic distortion(THD)on AC side voltage,investment cost of AC filters and telephone harmonic form factor(THFF)is established.An improved MOEA/D is proposed to realise the triple-objective optimal design for AC filters more efficiently.The improved MOEA/D adds a particular mutation operator,which can not only to prevent MOEA/D from getting stuck at local optimum but also accelerate the convergence to the optimum solution while the algorithm approaches the neighbourhood of the optimum solution.A three-dimensional fuzzy evaluation system is designed to select the optimum solution of the triple-objective optimisation.A case of±500 kV HVDC system is simulated.Taking the±500 kV HVDC system as the prototype system,a dynamic simulation experimental platform of the rectification system of the direct current transmission system with AC filters is designed and established based on the similarity principle.Both the simulation and experimental results verify that the proposed method have excellent performance.展开更多
基金Industrial Internet Development Project of the Ministry of Industry and Information Technology,Grant/Award Number:TC190A449National Key Research and Development Program of China,Grant/Award Number:2020YFB2010900+2 种基金Special Support Plan for Zhejiang Province High‐level Talents,Grant/Award Number:2022R52012Major Scientific Infrastructure Project of the Zhejiang Lab,Grant/Award Number:ZJKYHTZYZ10300020201229001National Natural Science Foundation of China,Grant/Award Number:52177119。
文摘One key concept of Industry 4.0 is the industrial digital twin(DT)-a virtual replica of physical assets,processes,and systems.DTs optimise operations,enhance productivity,and facilitate innovation across various industries,including manufacturing,energy,healthcare,and transportation.This paper presents a multi-domain and multi-time scale modelling and simulation platform,featuring built-in model libraries that represent diverse physical,chemical,and behavioural properties.A comprehensive system model-ling approach and a closed-loop industrial control system based on DTs are developed,showcasing advanced control,optimisation,and system security research capabilities.The architecture and advantages of the novel generation modelling platform are detailed,with specific applications highlighted,underscoring its contributions to the process industry.
基金Supported by Project of Taizhou Science and Technology Bureau(TS019)
文摘In this study, a xylanase-produeing Aspergillus niger strain, NS-1, was screened and isolated from agricultural and forestry wastes. Based on single-fac- tor experiments, the effects of different carbon sources, composite carbon sources, nitrogen sources, calcium carbonate concentrations, initial pH and surfactants on xylanase production by A. niger NS-1 were investigated. The results indicated that the most appropriate carbon source was corncobs ; the best composite carbon source was corncobs + xylan, which was conducive to xylanase secretion; the most suitable nitrogen source was ammonium sulfate. Xylanase activity reached the highest in the medium added with 1.5% calcium carbonate and SDS as a surfactant with an initial pH of 5.0. This study provided the basis for the production of high-activity xylanase.
基金supported by the National Key R&D Program of China(No.2017YFE0300106)National Natural Science Foundation of China(No.12075049)the Fundamental Research Funds for the Central Universities(Nos.DUT20LAB201 and DUT21LAB110)。
文摘In the design of negative hydrogen ion sources,a magnetic filter field of tens of Gauss at the expansion region is essential to reduce the electron temperature,which usually results in a magnetic field of around 10 Gauss in the driver region,destabilizing the discharge.The magnetic shield technique is proposed in this work to reduce the magnetic field in the driver region and improve the discharge characteristics.In this paper,a three-dimensional fluid model is developed within COMSOL to study the influence of the magnetic shield on the generation and transport of plasmas in the negative hydrogen ion source.It is found that when the magnetic shield material is applied at the interface of the expansion region and the driver region,the electron density can be effectively increased.For instance,the maximum of the electron density is 6.7×10^(17)m^(-3)in the case without the magnetic shield,and the value increases to 9.4×10^(17)m^(-3)when the magnetic shield is introduced.
基金supported by the National Natural Science Foundation of China(611630606110320461462007)
文摘In modern data centers, because of the deadline- agnostic congestion control in transmission control protocol (TCP), many deadline-sensitive flows can not finish before their deadlines. Therefore, providing a higher deadline meeting ratio becomes a critical challenge in the typical online data intensive (OLDI) ap- plications of data center networks (DCNs). However, a problem named as priority synchronization is found in this paper, which de- creases the deadline meeting ratio badly. To solve this problem, we propose a priority probability deceleration (P2D) deadline-aware TCP. By using the novel probabilistic deceleration, p2D prevents the priority synchronization problem. Simulation results show that P2D increases the deadline meeting ratio by 20% compared with D2TCP.
文摘Objective There are several reports that suggest a significant role played by microRNAs(miRNAs) in cell invasion, metastasis, differentiation, and apoptosis in lung cancers. miR-375 is one such miRNA that has been detected in a variety of tumors, but its specific activity in non-small cell lung cancer(NSCLC) remains unclear. Methods In this study, we regulated the expression of miR-375, to evaluate its influence on the 14-3-3ζ/ERK/MYC pathway in NSCLC. Results The results of our experiments suggest that miR-375 and 14-3-3ζ are highly expressed in NSCLC, and the over-expression of miR-375 increases the invasive, metastatic, and proliferative ability and decreases the apoptotic ability of NSCLC cells. In addition, protein expression levels of 14-3-3ζ, p-ERK, and MYC increased following the overexpression of miR-375. Conclusion Overall, our findings indicate that miR-375 increases the malignant potential of NSCLC via the 14-3-3ζ/ERK/MYC pathway.
文摘Let F be a graph and H be a hypergraph.We say that H contains a Berge-F If there exists a bijectionψ:E(F)→E(H)such that for Ve E E(F),e C(e),and the Turan number of Berge-F is defined to be the maximum number of edges in an r-uniform hypergraph of order n that is Berge-F-free,denoted by ex,(n,Berge-F).A linear forest is a graph whose connected components are all paths or isolated vertices.Let Ln,k be the family of all linear forests of n vertices with k edges.In this paper,Turan number of Berge-Ln,in an r-uniform hypergraph is studied.When r≥k+1 and 3≤r≤l[]=1,we determine 2 the exact value of ex,(n,Berge-Ln,)respectively.When K-1≤r≤k,we 2 determine the upper bound of ex,(n,Berge-Ln,).
基金National Natural Science Foundation of China(11874370,61675217)Strategic Priority Research Program of Chinese Academy of Sciences(XDB16030700)+5 种基金Key Research Program of Frontier Science of Chinese Academy of Sciences(QYZDB-SSW-JSC041)Program of Shanghai Academic Research Leader(17XD1403900)Natural Science Foundation of Shanghai(18ZR1444700)Shanghai Rising-Star Program(A type 19QA1410000)Youth Innovation Promotion Association of the Chinese Academy of SciencesHigh-End Foreign Expert Fellowship of the Ministry of Science and Technology of the P.R.China(G20190161002)
文摘This work reports the real-time observation of the interlayer lattice vibrations in bilayer and few-layer PtSe_2 by means of the coherent phonon method. The layer-breathing mode and standing wave mode of the interlayer vibrations are found to coexist in such a kind of group-10 transition metal dichalcogenides(TMDCs). The interlayer breathing force constant standing for perpendicular coupling(per effective atom) is derived as 7.5 N/m,2.5 times larger than that of graphene. The interlayer shearing force constant is comparable to the interlayer breathing force constant, which indicates that PtSe2 has nearly isotropic interlayer coupling. The low-frequency Raman spectroscopy elucidates the polarization behavior of the layer-breathing mode that is assigned to have A1 g symmetry. The standing wave mode shows redshift with the increasing number of layers, which successfully determines the out-of-plane sound velocity of PtSe2 experimentally. Our results manifest that the coherent phonon method is a good tool to uncover the interlayer lattice vibrations, beyond the conventional Raman spectroscopy limit. The strong interlayer interaction in group-10 TMDCs reveals their promising potential in high-frequency(~terahertz) micro-mechanical resonators.
基金This study was supported by the National Key R&D Program of China(no.2017YFA0207201)the National Natural Science Foundation(nos.21727808,21574065,21604038,21971114,21604040,and 51702155)+1 种基金the National Science Foundation for Distinguished Young Scholars(no.21625401)the Jiangsu Provincial Funds for Natural Science Foundation(nos.BK20160975,BK20160981,and BK20170975).
文摘Selective hydrogenation of alkynes to alkenes remains challenging in the field of catalysis due to the ease of over-hydrogenated of alkynes to alkanes.Favorably,the incorporation of metal nanoparticles(MNPs)into metal-organic frameworks(MOFs)provides an opportunity to adjust the surface electronic properties of MNPs for selective hydrogenation of alkynes.Herein,we used differentmetal-O clusters of MOFs to regulate the electronic status of platinum nanoparticles(Pt NPs)toward overhydrogenation,semihydrogenation,and unhydrogenation of phenylacetylene.Specifically,Pt/Fe-O cluster-based MOFs are found to reduce the electronic density on Pt NPs and inhibit the overhydrogenation of styrene,leading to an 80%increase in selectivity toward a semihydrogenation product(styrene).Meanwhile,Cu-O cluster-based MOFs generate high oxidation states of Pt NPs and release Cu^(2+)ions,which worked together to deactivate Pt NPs in the hydrogenation reaction entirely.Thus,our studies illustrate the critical role of metal-O clusters in governing chemical environments within MOFs for the precise control of selective hydrogenation of alkynes,thereby,offering appealing opportunities for designing MNPs/MOFs catalysts to prompt a variety of reactions.
文摘A triple-objective optimal design method for AC filters in high voltage direct current(HVDC)system based on an improved multi-objective evolutionary algorithm based on decomposition(MOEA/D)is proposed.A triple-objective optimisation mathematical model including total harmonic distortion(THD)on AC side voltage,investment cost of AC filters and telephone harmonic form factor(THFF)is established.An improved MOEA/D is proposed to realise the triple-objective optimal design for AC filters more efficiently.The improved MOEA/D adds a particular mutation operator,which can not only to prevent MOEA/D from getting stuck at local optimum but also accelerate the convergence to the optimum solution while the algorithm approaches the neighbourhood of the optimum solution.A three-dimensional fuzzy evaluation system is designed to select the optimum solution of the triple-objective optimisation.A case of±500 kV HVDC system is simulated.Taking the±500 kV HVDC system as the prototype system,a dynamic simulation experimental platform of the rectification system of the direct current transmission system with AC filters is designed and established based on the similarity principle.Both the simulation and experimental results verify that the proposed method have excellent performance.