Magnetic compression anastomosis to restore biliary tract continuity after obstruction following major abdominal trauma:A case report

BACKGROUND The combination of magnetic compression anastomosis(MCA)and endoscopy has been used to treat biliary stricture after liver transplantation.However,its use for the treatment of complex biliary obstruction after major abdominal trauma has not been reported.This case report describes the successful use of MCA for the treatment of biliary obstruction resulting from major abdominal trauma.A 23-year-old man underwent major abdominal surgery(repair of liver rupture,right half colon resection,and ileostomy)following a car accident one year ago.The abdominal drainage tube,positioned at the Winslow foramen,was draining approximately 600-800 mL of bile per day.During the two endoscopic retrograde cholangiopancreatography procedures,the guide wire was unable to enter the common bile duct,which prevented placement of a biliary stent.MCA combined with endoscopy was used to successfully achieve magnetic anastomosis of the peritoneal sinus tract and duodenum,and then a choledochoduodenal stent was placed.Finally,the external biliary drainage tube was removed.The patient achieved internal biliary drainage leading to the removal of the external biliary drainage tube,which improved the quality of life.CONCLUSION Magnetic compression technique can be used for the treatment of complex biliary obstruction with minimal operative trauma.

Clinical feasibility of laparoscopic left lateral segment liver resection with magnetic anchor technique:The first clinical study from China

BACKGROUND Magnetic anchor technique(MAT)has been applied in laparoscopic cholecystectomy and laparoscopic appendectomy,but has not been reported in laparoscopic partial hepatectomy.AIM To evaluate the feasibility of the MAT in laparoscopic left lateral segment liver resection.METHODS Retrospective analysis was conducted on the clinical data of eight patients who underwent laparoscopic left lateral segment liver resection assisted by MAT in our department from July 2020 to November 2021.The Y-Z magnetic anchor devices(Y-Z MADs)was independently designed and developed by the author of this paper,which consists of the anchor magnet and magnetic grasping apparatus.Surgical time,intraoperative blood loss,intraoperative accidents,operator experience,postoperative incision pain score,postoperative complications,and other indicators were evaluated and analyzed.RESULTS All eight patients underwent a MAT-assisted laparoscopic left lateral segment liver resection,including three patients undertaking conventional 5-port and five patients having a transumbilical single-port operation.The mean operation time was 138±34.32 min(range 95-185 min)and the mean intraoperative blood loss was 123±88.60 mL(range 20-300 mL).No adverse events occurred during the operation.The Y-Z MADs showed good workability and maneuverability in both tissue and organ exposure.In particular,the operators did not experience either a“chopstick”or“sword-fight”effect in the single-port laparoscopic operation.CONCLUSION The results show that the MAT is safe and feasible for laparoscopic left lateral segment liver resection,especially,exhibits its unique abettance for transumbilical single-port laparoscopic left lateral segment liver resection.

培美曲塞致皮肤色素沉着与肺腺癌化疗疗效关系的研究

目的:探讨晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)中肺腺癌患者使用培美曲塞化疗出现色素沉着及其与临床病理特征、培美曲塞化疗疗效的相关性。方法:收集新疆医科大学附属肿瘤医院2016年1月至2018年12月经组织病理证实为肺腺癌患者117例,采用不良事件的通用术语标准(CTCAE)4.0版对因使用培美曲塞出现皮肤色素沉着不良反应进行分级,并结合临床病理特征、培美曲塞的化疗疗效进行分析。结果:皮肤色素沉着发生率为43.6%(51/117),不同年龄、性别、肿瘤分期、肿瘤分化程度及吸烟情况的晚期肺腺癌患者的皮肤色素沉着发生率差异无统计学意义(P>0.05);出现皮肤色素沉着的患者与未出现皮肤色素沉着的患者相比,化疗有效率更高(47.1%vs.24.2%,P<0.05);出现皮肤色素沉着的患者无进展生存期(progression-free survival,PFS)显著长于未出现皮肤色素沉着的患者(6.2个月vs.4.1个月,P<0.05)。结论:培美曲塞治疗后出现皮肤色素沉着的患者有效率更高,皮肤色素沉着可能成为培美曲塞治疗晚期NSCLC的预后指标。

气液喷射器的结构设计与性能分析

喷射式环流反应器是一种高效的多相反应器,由于其具有良好的传热、传质和混合特性,目前已被广泛应用于生物、化学、制冷和环境保护等工程领域。气液喷射器作为喷射式环流反应器的核心部件之一,其结构尺寸对环流反应器的传质特性和适用环境都具有显著影响。为考察结构尺寸对喷射器性能的影响,本文根据其工作原理,设计了一台模试气液喷射器,并通过冷模试验对其进行性能测试研究。试验结果表明:气液喷射器的引气能力主要取决于其混合喉管与喷嘴出口截面比f3/f1以及喷射器进出口压力降Δpp/Δpc,而环流反应器的气含率仅与喷射器的液相射流量和气体引射量有关。相同液相流量条件下,喷射器的最大引射空气量随截面比f3/f1的增大而增大,反应器内的平均气含率随之增加;提高液相射流与引射气体的速度差能够加强两股流体间的剪切作用,使气泡更易发生破碎。当喷射器的气液比大于2.6时,反应器内的混合流体可达到乳化状态。

Role of transforming growth factor-beta signaling pathway in pathogenesis of benign biliary stricture

AIM: To characterize the expression of members of the transforming growth factor-beta (TGF-β)/Smad/ connective tissue growth factor (CTGF) signaling pathway in the tissue of benign biliary stricture, and to investigate the effect of TGF-β signaling pathway in the pathogenesis of benign biliary stricture. METHODS: Paraffin embedded materials from 23 cases of benign biliary stricture were analyzed for members of the TGF-β/Smad/CTGF signaling pathway. TGF-β_1, TβRⅠ, TβRⅡ, Smad4, Smad7 and CTGF protein were detected by immunohistochemical strepto-advidinbiotin complex method, and CTGF mRNA was evaluated by hybridization in situ, while 6 cases of normal bile duct served as controls. The percentages of positive cells were counted. The correlation between TGF-β_1, Smad4 and CTGF was analyzed. RESULTS: The positive expression ratios of TGF-β_1, TβRⅠ , TβRⅡ , Smad4, CTGF and CTGF mRNA in 23 cases with benign biliary stricture were 91.3%, 82.6%, 87.0%, 78.3%, 82.6% and 65.2%, respectively, signifi cantly higher than that in 6 cases of normal bile duct respectively (vs 33.3%, 16.7%, 50.0%, 33.3%, 50.0%, 16.7%, respectively, P < 0.05). The positiveexpression ratio of Smad7 in cases with benign biliary stricture was 70.0%, higher than that in normal bile duct, but this difference is not statistically signifi cant 70.0% vs 50%, P > 0.05). There was a positive correlation between positive expression of TGF-β_1, Smad4 and CTGF in cases with benign biliary stricture. CONCLUSION: The high expression of TGF-β/Smad/ CTGF signaling pathway plays an important role in the pathogenesis of benign biliary stricture.

Down-regulation of FoxM1 inhibits viability and invasion of gallbladder carcinoma cells, partially dependent on inducement of cellular senescence

AIM: To investigate the effect of knockdown of Forkhead box M1 (FoxM1) on the proliferation and invasion capacities of human gallbladder carcinoma (GBC)-SD cells.

H2S废气反应炉燃烧数值模拟

针对某炼油化工厂H2S反应炉设计的不同结构的燃烧器进行三维数值模拟,研究了不同燃烧器结构参数、燃料气成分与分配比例、反应炉花墙结构等因素对炉内流动与燃烧的影响,并确定了合理的燃烧器结构。结果表明:原始燃烧器结构下,单烧酸性气工况时,降低内圈酸性气比例有利于H2S的完全燃烧,炉膛出口烟温有所提高;优化后的燃烧器结构较原始结构下,增强了内圈酸性气与空气的混合,更有利于H2S气体的燃烧;反应炉内花墙结构能造成炉膛内烟气回流,提高了烟气的停留时间,有利于H2S气体的燃烧完全;掺烧天然气工况较单烧酸性气工况,炉内燃烧变差。

Comparing and evaluating the nationally determined contributions of the top six emitters under the Paris Agreement goals

Comparing and evaluating the Nationally Determined Contribution(NDC) is an important element in global stocktake in the post-Paris climate negotiations, aimed at closing the emissions gap with the Paris Agreement goals. To date, however, there has still been no explicit guideline or method. By applying emissions allowance allocated by 16 schemes as benchmarks, this paper tries to compare and evaluate the NDCs of the top six emitters, which jointly account for about 70% of the world's CO_2 emissions. Results show that the four developed countries' NDCs lack ambition with respect to most allocations under 2℃ and all under 1.5℃, indicating they need to substantially ratchet up their NDCs and lead elevating mitigation. Evaluating cumulative emissions is more likely to clarify the ambition and fairness of China's NDC. If considering cumulative emissions, China's NDC is aligned with the median of cumulative allowances under 2℃ and within the 1.5℃ range. The Paris Agreement invited the Parties to communicate the mid-century low emissions strategies. This paper also tries to explore the mid-century mitigation in the perspective of allocations, which might provide decision-makers with some useful information when envisaging the post-NDC mitigation.

Correction to“Downregulation of FoxM1 inhibits the viability and invasion of gallbladder carcinoma cells,partially dependent on the induction of cellular senescence”

We corrected the mistake of Figure 3,and replaced the incorrect images with the correct ones.The“adenovirus”was a typographical error in writing,and should be revised to“lentivirus”.

Investigate the Effect of the Magnetic Field on the Mechanical Properties of Silicone Rubber-Based Anisotropic Magnetorheological Elastomer during Curing Process

In this investigation,a new silicone rubber-based MRE material was prepared to be used as a forming medium in manufacturing thin-walled complexshaped Ni-based tubes through the bulging process.Thus,it is significant to investigate the effect of magnetic field intensity,magnetic field loading time,and angle on the mechanical properties of the prepared MRE material during the curing process.The obtained results showed that increasing the magnetic field intensity during the curing process can improve the orientation of the chain structure in the elastomer matrix effectively.However,its mechanical properties are the best under the corresponding magnetic field intensity of 321 mT.Besides,by extending the magnetic field loading time in the curing process,the orientation of the chain structure was optimized,at the same time,the mechanical properties were also improved,and the best loading time is about 20–25 min.By changing the loading angle of the magnetic field during the curing process,the mechanical properties of the MRE were improved.When the loading angle of the magnetic field is 90°,the elastomer showed the best compression mechanical properties and excellent compression reversibility.Besides,for the anisotropic MRE material,the performance with magnetic compression is always better than that without magnetic compression.

Drag Reduction Characteristics of Microstructure Inspired by the Cross Section of Barchan Dunes under High Speed Flow Condition

A new type of microstructure inspired by the cross section of barchan dunes was proposed to reduce windage,which was considered as a passive drag reduction technology in aerospace manufacturing field.Computational fluid dynamics method was carried out to discuss the effect of the microstructure on the skin friction reduction under high velocity flow condition.Different microstructure heights were employed to survey the reduction of drag.The results illustrated that the appearance of microstructure led to a generation of pressure drag in non-smooth model(with microstructures inspired by cross section of barchan dune)in contrast to smooth model.However,the microstructure significantly increased the thickness of the low-speed fluid by 11.4%in the near-wall flow field,causing the low-speed fluid to rise and decreasing the velocity gradient near the wall,thereby reducing viscous resistance.In addition,high-speed fluid flowed above the microstructure units instead of along the inner side of the units due to the influence of micro-vortex,resulting in a reduction of friction near the surface.Further-more,micro-vortex was considered to be the significant internal factor to achieve turbulent drag reduction since it could not only reduce the viscous resistance by promoting the fluid flow above the microstructure but also pro-vide a reverse thrust force.The understanding of the mechanism of drag reduction provides theoretical guidance for further fabrication of drag reduction coatings using renewable materials.

Clinical study of extrahepatic biliary adenoma

BACKGROUND Biliary adenomas that occur in the extrahepatic biliary tree are rare.It is difficult to distinguish it from cholangiocarcinoma or cholangiolithiasis by various imaging examinations,and it is very easy to be misdiagnosed.AIM To evaluate the cumulative experiences including clinical characteristics and treatments of nine patients diagnosed with extrahepatic biliary adenoma admitted to the First Affiliated Hospital of Xi’an Jiaotong University from 2016 to 2022.METHODS A total of nine patients were included in our study.The laboratory examinations,disease diagnosis,therapy and pathological characteristics,and follow-up of every patient were evaluated.RESULTS Our cohort consisted of six females and three males with an average diagnosis age of 65.1 years(range 46-87).Six extrahepatic biliary adenomas were located in the common bile ducts and three in the hepatic duct.On initial presentation,all of the patients have symptom of biliary origin,including obstructive jaundice(4/9,44.4%),abdominal pain(6/9,66.7%),and fever(3/9,33.3%).Preoperative imaging examination considered bile duct carcinoma in 6 cases and bile duct calculi in 3 cases.All the patients received surgical treatment and were confirmed by pathology as biliary adenoma.The symptoms improved significantly in all 9 patients after surgery.Seven of nine patients recovered well at follow-up without tumor recurrence.One patient died 2 mo after the surgery due to heart failure.One patient developed jaundice again 8 mo after surgery,underwent endoscopic retrograde cholangiopancreatography and biliary stent placement.CONCLUSION Benign extrahepatic biliary tumors are rare and difficult to diagnosis preoperatively.Intraoperative choledochoscopy and timely biopsy may offer great advantages.

开窗术复位胫骨远端关节面骨块治疗Ⅱ型Pilon骨折

2018年2月~2020年1月,我科采用开窗术复位胫骨远端关节面骨块治疗10例Ⅱ型Pilon骨折患者,疗效满意,报道如下。1材料与方法1.1病例资料本组10例,男7例,女3例,年龄19~55岁。左侧6例,右侧4例。伤后至手术时间6~14 d。1.2治疗方法硬膜外麻醉或全身麻醉下手术。患者仰卧位。因Ⅱ型Pilon骨折胫骨远端背侧骨面较为完整,无法直视下复位胫骨远端关节面骨块,故根据骨块位置使用薄宽骨刀在胫骨前侧方开窗,大小约1.5 cm×2.0 cm,注意勿损伤开窗骨块的远端关节面软骨。形成的骨块向远端翻转,尽量不完全游离骨块使其能带有一定的血液循环。通过开窗部位使用克氏针将开窗暴露的6块主要骨块中方便操作的任意1块进行临时固定,再复位其余主要骨块。

The Study on the Sports Injuries and Psychological Stress of Chinese Elite Players

Through national gymnastics to 30 active athletes and 30 national women＇s handball training athletes, which results in the paper are as follows： outstanding gymnastics. The main part of injury is elbow, ankle, and the degree of damage to elbow as the worst. Women＇s handball player injury occurred campaign main pan is knees joint, ankle, with the most serious level of knee injuries. Outstanding women athletes in gymnastics and handball injury occurred campaign＇s state anxiety level is higher, were reached 49.37 ± 94 and 49. 00 ±61.3, excellent gymnast sports injury of the main source of stress for coach criticism, leading opponent table Now when the good. Good men＇s gymnastics athlete sports injury of main source of stress for physical or psychological made a mistake, coach criticism, suffered severe pain or injury After. Outstanding female handball player of the main source of the sports injury stress for the referee injustice, not the bad climate space equipment and error, etc. 4, excellent gymnastics The main way to deal with the players face for attributed to the outside world not controllable factors, focus your attention on the action or distracting, excellent handball in the athletes to diversify To strengthen the way to deal with the game for faith, quickly forget unhappy experience and experience of stress take more carefully way. The abstract should summarize the contents of the paper and should contain at least 70 and at most 150 words. It should be set in 9-point font size and should be inset 1.0 cm from the fight and left margins. There should be two blank （10-point） lines before and aiter the abstract. This document is in the required format.

Discussion on Anti-seepage Wall and Anti-seepage Technology of Water Conservancy Project

The water infiltration problem of water conservancy projects is one of the more common problems in the construction of water conservancy projects,which seriously affects the overall construction quality and safety of water conservancy projects.This article studies the causes of water infiltration in water conservancy projects and introduces related antiseepage technologies,hoping to be a reference for the implementation of anti-seepage projects.Through research,it is found that the factors that cause water infiltration in water conservancy projects include water conservancy project structural changes,environmental factors and construction factors.Relevant personnel can use concrete anti-seepage wall construction technology and high-pressure jet grouting technology to do the relevant anti-seepage work of water conservancy projects.

Sex-biased single-cell genetic landscape in mice with autism spectrum disorder

Autistic spectrum disorder(ASD)is a male-biased,heterogeneous neurodevelopmental disorder that affects approximately 1%e2%of the population.Prenatal exposure to valproic acid(VPA)is a recognized risk factor for ASD,but the cellular and molecular basis of VPA-induced ASD at the single-cell resolution is unclear.Here,we aim to compare the cellular and molecular differences in the hippocampus between male and female prenatal mice with ASD at the single-cell transcriptomic level.The transcriptomes of more than 45,000 cells are assigned to 12 major cell types,including neurons,glial cells,vascular cells,and immune cells.Cell type-specific genes with altered expression after prenatal VPA exposure are analyzed,and the largest number of differentially expressed genes(DEGs)are found in neurons,choroid plexus epithelial cells,and microglia.In microglia,several pathways related to inflammation are found in both males and females,including the tumor necrosis factor(TNF),nuclear factor kappa B(NF-kB),toll-like receptor(TLR),and mitogen-activated protein kinase(MAPK)signaling pathways,which are important for the induction of autistic-like behavior.Additionally,we note that several X-linked genes,including Bex1,Bex3,and Gria3,were among the male-specific DEGs of neurons.This pioneering study describes the landscape of the transcriptome in the hippocampus of autistic mice.The elucidation of sexual differences could provide innovative strategies for the prevention and treatment of ASD.

计算最小体积覆盖椭球的坐标轴下降算法

最小体积覆盖椭球问题是一个基本的凸优化问题.本文给出最小体积覆盖椭球问题的新性质—对算法依坐标轴光滑性,据此提出一种坐标轴下降算法来计算最小体积覆盖椭球并证明该算法的收敛速度是全局次线性收敛且局部线性收敛的.从计算时间角度来看,该算法优于经典的Frank-Wolfe算法,并且这种优势对于高维数据集尤为明显.更进一步,我们发现该算法在计算最小体积覆盖椭球问题方面比随机坐标轴下降算法更有优势.最后通过大规模数值算例测试来验证我们得到的理论结果.

基于宏病毒组学技术挖掘猪腹泻粪便的病毒群落组成

为系统鉴定现阶段上海地区仔猪腹泻样品中的病毒群落组成,本研究利用宏病毒组学技术对临床采集的猪腹泻粪便进行了宏病毒高通量测序。结果显示,测序获得了1,676,726个RNAcontig和95,111个DNAcontig,RNA病毒和DNA病毒序列分别占比38.58%和3.10%。其中星状病毒科、杯状病毒科和小RNA病毒科是病毒总群落中占比最高的前3个科。虽然DNA病毒在病毒总群落中的占比较低,但其单组分环状DNA(CRESS-DNA)病毒种类丰富多样,包含有18种CRESS-DNA病毒。经基因组序列深度拼接,共获得了46条病毒全基因组序列,包括2株猪星状病毒和3株类似星状病毒、2株札幌病毒、16株小双节RNA病毒和23株CRESS-DNA病毒。其中1株札幌病毒归属于GII/3亚型,与人札幌病毒亲缘性较近。16株小双节RNA病毒中有4株归属于GGI亚型,其余12株归属于GGII亚型。23株CRESS-DNA病毒中有1株归属于类双生病毒科、12株CRESS-DNA病毒归属于小环状DNA病毒科,另外10株CRESS-DNA病毒未分类。本研究揭示现阶段猪腹泻粪便中以RNA病毒为主导,且存在宿主多样性,提示可能存在种间基因重组,病原潜在危害性需进一步挖掘和验证。研究数据将为临床猪腹泻病防控提供参考和借鉴。

Ⅲ型干扰素相关生物学功能的研究进展

干扰素(Interferon,IFN)是一类具有多功能生物活性的糖蛋白,包含3个家族(Ⅰ型、Ⅱ型和Ⅲ型)。Ⅲ型干扰素(TypeⅢinterferon,IFN-Ⅲ)是近16年发现的新型干扰素,其诱导过程及生物学功能与I型干扰素(TypeⅠinterferon,IFN-Ⅰ)相似,在抗病毒、免疫调节、抗肿瘤、抑制自身免疫病、抑制过敏性哮喘以及抗细菌和真菌等方面具有重要作用。本文将从IFN-Ⅰ和IFN-Ⅲ的分类、序列同源性和信号传导等方面进行阐述,并结合近年来IFN-Ⅲ在疾病治疗过程中所取得的成就,综述IFN-Ⅲ的生物学功能,旨在为IFN-Ⅲ的深入研究以及在多种疾病的诊断和防控中提供参考。

Finite element modelling and experimental investigation of the impact of filling different materials in copper tubes during 3D free bending process

3D free bending process,an advanced metal forming technology,has attracted much attention due to its unique geometrical flexibility and efficiency.Filling tubes with materials may effectively reduce the distortion in the cross-section area and restrain wrinkling and collapse of tube wall.In the present study,the impacts of filling different materials on the copper tubes during 3D free bending process were investigated.We have found that copper tubes filled with low melting point alloys could induce the most uniform stress distribution,which result in better formability and moderate thickness changing rates when compared to SS304 steel balls and PU rubbers.The lowest ellipticity reached to 1.467%.