目的探讨Kringle结构IV型-2亚型结构(KIV-2)拷贝数及载脂蛋白a[Apo(a)]颗粒大小与2型糖尿病和冠心病的相关性。方法回顾性选取2019年6月至2020年6月于复旦大学附属中山医院青浦分院就诊的180例体检者为研究对象,对临床资料进行收集和分...目的探讨Kringle结构IV型-2亚型结构(KIV-2)拷贝数及载脂蛋白a[Apo(a)]颗粒大小与2型糖尿病和冠心病的相关性。方法回顾性选取2019年6月至2020年6月于复旦大学附属中山医院青浦分院就诊的180例体检者为研究对象,对临床资料进行收集和分析后将其分为3组:正常对照组、冠心病组和糖尿病组,每组各60例。检测3组人群的空腹血糖、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbA1c)、总胆固醇、甘油三酯、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)和脂蛋白(a)[Lp(a)]含量;通过RT-PCR法测定KIV-2拷贝数,并通过检测KIV-2结构重复数确定Apo(a)颗粒大小;分析Lp(a)拷贝数、Apo(a)颗粒大小分别与2型糖尿病和冠心病的关系。结果冠心病组和糖尿病组空腹血糖、2 h PG、HbA1c、总胆固醇、甘油三酯、LDL-C、Lp(a)水平均高于正常对照组,HDL-C、KIV-2拷贝数低于正常对照组,差异均有统计学意义(P<0.05),而冠心病组与糖尿病组HDL-C水平比较,差异无统计学意义(P>0.05)。2型糖尿病和冠心病分别与KIV-2拷贝数相关性显著,与Apo(a)颗粒大小相关性不显著,且LP(a)浓度与KIV-2拷贝呈负相关。结论Apo(a)颗粒大小与2型糖尿病和冠心病无明显相关性,而KIV-2拷贝数与2型糖尿病和冠心病有明显相关性。检测KIV-2拷贝数可为2型糖尿病和冠心病的诊断与治疗提供依据。展开更多
Two large-pore metal-doped aluminophosphates, Mn4Al5（PO4 ）12[N（ C2H4NH3）3]3 [ N（C2H4NH3）2·（C2H4NH2）]（NH4）2·14H=O（Mn4-NJU） and Co4Al5（PO4）12[N（C2H,NH3）3][N（C2H4NH3）2（C2H4NH2）]3· （ N...Two large-pore metal-doped aluminophosphates, Mn4Al5（PO4 ）12[N（ C2H4NH3）3]3 [ N（C2H4NH3）2·（C2H4NH2）]（NH4）2·14H=O（Mn4-NJU） and Co4Al5（PO4）12[N（C2H,NH3）3][N（C2H4NH3）2（C2H4NH2）]3· （ NH4 ）4· 13H2O （ Co4-NJU） , which have the same open framework structures, were hydrothermally synthesized. The structures of these compounds consist of TO4 tetrahedra, which are linked together by corner-sharing to form an open framework with unique intersecting twelve-membered ring channels in three dimensions. The compounds crystallize in cubic space group I（-4）3m with α= 1. 6795（2） nm and V=4. 7374（9） nm^3 for Mn4-NJU, and a=1. 67372（19） nm and V = 4. 6887 （9） nm^3 for Co4-NJU, respectively. Single crystal structure analyses show that the protruding O atoms of the frameworks of the compounds are linked to protonated 4-（ 2-aminoethyl ）diethylenetriamine （TREN, C6H18N4 ） ions in the windows by means of hydrogen-bonding under the hydrothermal condition. It is also found that the components inside the super cages of the compounds are changeable, and the metal ions M^2＋ （M = Mn, Co） and Al^3＋ disorderedly occupy the same crystallographic positions.展开更多
文摘目的探讨Kringle结构IV型-2亚型结构(KIV-2)拷贝数及载脂蛋白a[Apo(a)]颗粒大小与2型糖尿病和冠心病的相关性。方法回顾性选取2019年6月至2020年6月于复旦大学附属中山医院青浦分院就诊的180例体检者为研究对象,对临床资料进行收集和分析后将其分为3组:正常对照组、冠心病组和糖尿病组,每组各60例。检测3组人群的空腹血糖、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbA1c)、总胆固醇、甘油三酯、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)和脂蛋白(a)[Lp(a)]含量;通过RT-PCR法测定KIV-2拷贝数,并通过检测KIV-2结构重复数确定Apo(a)颗粒大小;分析Lp(a)拷贝数、Apo(a)颗粒大小分别与2型糖尿病和冠心病的关系。结果冠心病组和糖尿病组空腹血糖、2 h PG、HbA1c、总胆固醇、甘油三酯、LDL-C、Lp(a)水平均高于正常对照组,HDL-C、KIV-2拷贝数低于正常对照组,差异均有统计学意义(P<0.05),而冠心病组与糖尿病组HDL-C水平比较,差异无统计学意义(P>0.05)。2型糖尿病和冠心病分别与KIV-2拷贝数相关性显著,与Apo(a)颗粒大小相关性不显著,且LP(a)浓度与KIV-2拷贝呈负相关。结论Apo(a)颗粒大小与2型糖尿病和冠心病无明显相关性,而KIV-2拷贝数与2型糖尿病和冠心病有明显相关性。检测KIV-2拷贝数可为2型糖尿病和冠心病的诊断与治疗提供依据。
文摘Two large-pore metal-doped aluminophosphates, Mn4Al5（PO4 ）12[N（ C2H4NH3）3]3 [ N（C2H4NH3）2·（C2H4NH2）]（NH4）2·14H=O（Mn4-NJU） and Co4Al5（PO4）12[N（C2H,NH3）3][N（C2H4NH3）2（C2H4NH2）]3· （ NH4 ）4· 13H2O （ Co4-NJU） , which have the same open framework structures, were hydrothermally synthesized. The structures of these compounds consist of TO4 tetrahedra, which are linked together by corner-sharing to form an open framework with unique intersecting twelve-membered ring channels in three dimensions. The compounds crystallize in cubic space group I（-4）3m with α= 1. 6795（2） nm and V=4. 7374（9） nm^3 for Mn4-NJU, and a=1. 67372（19） nm and V = 4. 6887 （9） nm^3 for Co4-NJU, respectively. Single crystal structure analyses show that the protruding O atoms of the frameworks of the compounds are linked to protonated 4-（ 2-aminoethyl ）diethylenetriamine （TREN, C6H18N4 ） ions in the windows by means of hydrogen-bonding under the hydrothermal condition. It is also found that the components inside the super cages of the compounds are changeable, and the metal ions M^2＋ （M = Mn, Co） and Al^3＋ disorderedly occupy the same crystallographic positions.
