RDH12-associated retinal degeneration caused by a homozygous pathogenic variant of 146C>T and literature review

AIM:To describe the clinical,electrophysiological,and genetic features of an unusual case with an RDH12 homozygous pathogenic variant and reviewed the characteristics of the patients reported with the same variant.METHODS:The patient underwent a complete ophthalmologic examination including best-corrected visual acuity,anterior segment and dilated fundus,visual field,spectral-domain optical coherence tomography(OCT)and electroretinogram(ERG).The retinal disease panel genes were sequenced through chip capture high-throughput sequencing and Sanger sequencing was used to confirm the result.Then we reviewed the characteristics of the patients reported with the same variant.RESULTS:A 30-year male presented with severe early retinal degeneration who complained night blindness,decreased visual acuity,vitreous floaters and amaurosis fugax.The best corrected vision was 0.04 OD and 0.12 OS,respectively.The fundus photo and OCT showed bilateral macular atrophy but larger areas of macular atrophy in the left eye.Autofluorescence shows bilateral symmetrical hypo-autofluorescence.ERG revealed that the amplitudes of a-and b-wave were severely decreased.Multifocal ERG showed decreased amplitudes in the local macular area.A homozygous missense variant c.146C>T(chr14:68191267)was found.The clinical characteristics of a total of 13 patients reported with the same pathologic variant varied.CONCLUSION:An unusual patient with a homozygous pathogenic variant in the c.146C>T of RDH12 which causes late-onset and asymmetric retinal degeneration are reported.The clinical manifestations of the patient with multimodal retinal imaging and functional examinations have enriched our understanding of this disease.

Concomitant treatment of ureteral calculi and ipsilateral pelvic sciatic nerve schwannoma with transperitoneal laparoscopic approach: A case report

BACKGROUND Schwannomas are rare peripheral neural myelin sheath tumors that originate from Schwann cells.Of the different types of schwannomas,pelvic sciatic nerve schwannoma is extremely rare.Definite preoperative diagnosis of pelvic schwannomas is difficult,and surgical resection is the gold standard for its definite diagnosis and treatment.CASE SUMMARY We present a case of pelvic schwannoma arising from the sciatic nerve that was detected in a 40-year-old man who underwent computed tomography for intermittent right lower back pain caused exclusively by a right ureteral calculus.Subsequently,successful transperitoneal laparoscopic surgery was performed for the intact removal of the stone and en bloc resection of the schwannoma.The total operative time was 125 min,and the estimated blood loss was inconspicuous.The surgical procedure was uneventful.The patient was discharged on postoperative day 5 with the simultaneous removal of the urinary catheter.However,the patient presented with motor and sensory disorders of the right lower limb,caused by partial damage to the right sciatic nerve.No tumor recurrence was observed at the postoperative appointment.CONCLUSION Histopathological examination of the specimen confirmed the diagnosis of a schwannoma.Thus,laparoscopic surgery is safe and feasible for concomitant extirpation of pelvic schwannomas and other pelvic and abdominal diseases that require surgical treatment.

Effect of low-degree astigmatism on the objective visual quality

AIM:To evaluate the effect of low-degree astigmatism on objective visual quality through the Optical Quality Analysis System(OQAS).METHODS:This study enrolled 46 participants(aged 23 to 30y,90 eyes)with normal or corrected-to-normal vision.The cylindrical lenses(0,0.5,0.75,1.0,and 1.25 D)were placed at the axial direction(180°,45°,90°,and 135°)in front of the eyes with the best correction to form 16 types of regular low-degree astigmatism.OQAS was used to detect the objective visual quality,recorded as the objective scattering index(OSI),OQAS values at contrasts of 100%,20%,and 9%predictive visual acuity(OV100%,OV20%,and OV9%),modulation transfer function cut-off(MTFcut-off)and Strehl ratio(SR).The mixed effect linear model was used to compare objective visual quality differences between groups and examine associations between astigmatic magnitude and objective visual quality parameters.RESULTS:Apparent negative relationships between the magnitude of low astigmatism and objective visual quality were observed.The increase of OSI per degree of astigmatism at 180°,45°,90°,and 135°axis were 0.38(95%CI:0.35,0.42),0.50(95%CI:0.46,0.53),0.49(95%CI:0.45,0.54)and 0.37(95%CI:0.34,0.41),respectively.The decrease of MTFcut-off per degree of astigmatism at 180°,45°,90°,and 135°axis were-10.30(95%CI:-11.43,-9.16),-12.73(95%CI:-13.62,-11.86),-12.75(95%CI:-13.79,-11.70),and-9.97(95%CI:-10.92,-9.03),respectively.At the same astigmatism degree,OSI at 45°and 90°axis were higher than that at 0°and 135°axis,while MTFcut-off were lower.CONCLUSION:Low astigmatism of only 0.50 D can significantly reduce the objective visual quality.

Development and validation of a machine learning-based early prediction model for massive intraoperative bleeding in patients with primary hepatic malignancies

BACKGROUND Surgical resection remains the primary treatment for hepatic malignancies,and intraoperative bleeding is associated with a significantly increased risk of death.Therefore,accurate prediction of intraoperative bleeding risk in patients with hepatic malignancies is essential to preventing bleeding in advance and providing safer and more effective treatment.AIM To develop a predictive model for intraoperative bleeding in primary hepatic malignancy patients for improving surgical planning and outcomes.METHODS The retrospective analysis enrolled patients diagnosed with primary hepatic malignancies who underwent surgery at the Hepatobiliary Surgery Department of the Fourth Hospital of Hebei Medical University between 2010 and 2020.Logistic regression analysis was performed to identify potential risk factors for intraoperative bleeding.A prediction model was developed using Python programming language,and its accuracy was evaluated using receiver operating characteristic(ROC)curve analysis.RESULTS Among 406 primary liver cancer patients,16.0%(65/406)suffered massive intraoperative bleeding.Logistic regression analysis identified four variables as associated with intraoperative bleeding in these patients:ascites[odds ratio(OR):22.839;P<0.05],history of alcohol consumption(OR:2.950;P<0.015),TNM staging(OR:2.441;P<0.001),and albumin-bilirubin score(OR:2.361;P<0.001).These variables were used to construct the prediction model.The 406 patients were randomly assigned to a training set(70%)and a prediction set(30%).The area under the ROC curve values for the model’s ability to predict intraoperative bleeding were 0.844 in the training set and 0.80 in the prediction set.CONCLUSION The developed and validated model predicts significant intraoperative blood loss in primary hepatic malignancies using four preoperative clinical factors by considering four preoperative clinical factors:ascites,history of alcohol consumption,TNM staging,and albumin-bilirubin score.Consequently,this model holds promise for enhancing individualised surgical planning.

Abnormalities of electroencephalography microstates in patients with depression and their association with cognitive function

BACKGROUND A growing number of recent studies have explored underlying activity in the brain by measuring electroencephalography(EEG)in people with depression.However,the consistency of findings on EEG microstates in patients with depression is poor,and few studies have reported the relationship between EEG microstates,cognitive scales,and depression severity scales.AIM To investigate the EEG microstate characteristics of patients with depression and their association with cognitive functions.METHODS A total of 24 patients diagnosed with depression and 32 healthy controls were included in this study using the Structured Clinical Interview for Disease for The Diagnostic and Statistical Manual of Mental Disorders,Fifth Edition.We collected information relating to demographic and clinical characteristics,as well as data from the Repeatable Battery for the Assessment of Neuropsychological Status(RBANS;Chinese version)and EEG.RESULTS Compared with the controls,the duration,occurrence,and contribution of microstate C were significantly higher[depression(DEP):Duration 84.58±24.35,occurrence 3.72±0.56,contribution 30.39±8.59;CON:Duration 72.77±10.23,occurrence 3.41±0.36,contribution 24.46±4.66;Duration F=6.02,P=0.049;Occurrence F=6.19,P=0.049;Contribution F=10.82,P=0.011]while the duration,occurrence,and contribution of microstate D were significantly lower(DEP:Duration 70.00±15.92,occurrence 3.18±0.71,contribution 22.48±8.12;CON:Duration 85.46±10.23,occurrence 3.54±0.41,contribution 28.25±5.85;Duration F=19.18,P<0.001;Occurrence F=5.79,P=0.050;Contribution F=9.41,P=0.013)in patients with depression.A positive correlation was observed between the visuospatial/constructional scores of the RBANS scale and the transition probability of microstate class C to B(r=0.405,P=0.049).CONCLUSION EEG microstate,especially C and D,is a possible biomarker in depression.Patients with depression had a more frequent transition from microstate C to B,which may relate to more negative rumination and visual processing.

“地方性的辩证法”笔谈

“地方性的辩证法”是由这几年文学创作上比较引人关注的作品和现象而提出的讨论话题,我只能说一些粗浅的感受,这些感受交织着不同的层次:一是地方性的写作面对或背对的是什么,更直白地说,它试图摆脱的束缚和限制是什么。有没有一种或多种有形无形的笼罩性的力量,要抽空地方性,使文学写作变得更为均质、同质,甚至空洞?从这个意义上说,地方性写作的取向是向下获取自由和解放的取向,这样的取向是内在于文学本身的。

计及气象因素与分时电价影响的综合能源系统负荷调控策略研究

用能高峰时段,综合能源系统多元负荷受气象因素影响,使其用能需求量短时持续上升,导致供需矛盾加剧;同时,综合能源系统多能耦合转换与蓄放单元的电驱动特点(如冰蓄冷空调、电制冷制冰)致使其用能成本受分时电价影响进一步增加。以供冷季用能高峰时段综合能源系统冷-电供需调控为研究对象,提出一种包含冷负荷需求自身调节与供冷功率主动控制的两阶段递进式调控策略,旨在实现多能供需平衡空间的拓展与用能成本的降低。基于模糊C均值聚类并考虑综合气象因素与分时电价的影响,选取调控时段;在第1阶段构建了温-湿舒适度最佳与冷能需求量最低的多目标负荷调节模型,在第2阶段提出了用能成本最低和运行能耗最小的多目标供冷输出功率主动控制策略;选取某校园综合能源系统实际运行数据进行算例仿真,采用ε-约束法以及多维偏好线性规划方法进行多目标求解,并基于用能舒适度变化的运行能耗、用能成本等指标,对比分析负荷需求在用能高峰时段调控优化前后的效果。结果表明,所提方法在满足用能舒适度的同时,能削减约13%的负荷需求,并降低约1.9%系统用能成本,有效缓解多能供需矛盾,增强系统运行的灵活性。

陈登铠“内外一统”发病观与痿证理论钩玄

探讨陈登铠《华医病理学》“内外一统”的病因和发病观,以及在伤寒、风论、痹论、痿论中的体现。其中痹论和痿论并论,主要表现为病因的“内外感召”和传变的“内外气化枢转”,并从“肺热叶焦”转向“痿疾取之阳明”的机制、悲哀太甚胞络绝致大经空虚、思虑过度与类“二阳之病发心脾”、治痿重视阳明4个方面探讨阳明在痿证理论中的重要意义。

生态位适宜度与公共研发组织创新价值——基于竞争与协同的中介效应

公共研发组织因所处创新生态系统创新资源的异质性而造成生态位适宜度差异,通过与其他主体竞争与协同实现价值共创。基于生态位适宜度和创新价值测度构建面板数据回归模型,实证检验2010—2020年中国内地31个省、自治区和直辖市数据,结果发现:①我国东部省份公共研发组织创新价值普遍较高;②北京、江苏、浙江、广东等省市创新生态位适宜度普遍较高,2020年各省份创新生态位适宜度值均实现不同程度提升;③生态位适宜度对公共研发组织创新价值具有显著正向影响,生态位适宜度通过协同效应和竞争效应提高公共研发组织创新价值;④按地区分组证实回归结果具有稳健性,并且不同地区创新生态位适宜度存在异质性。

Preparation of a functional fracturing fluid with temperature-and salt-resistance,and low damage using a double crosslinking network

Fracturing fluids(FFs)have been widely used to stimulate the tight reservoir.However,current FFs will not only lose their rheological property at high temperatures and high salt but also show an incomplete gel-breaking property.Herein,a double crosslinking network FF with pretty superiorities in rheology and low damage to the core was constructed by introducing both physical crosslinking and chemical crosslinking into the system.The construction of double crosslinking networks enhanced the rheology of this functional FF.The particle sizes of gel-breaking fluids are mainly distributed in 1.0e10,000 nm;furthermore,for every 10,000 mg/L increase in salinity,the particle size of the gel-breaking fluid is decreased by almost half.The adsorption capacity(<1.0 mg/g)gradually decreased with the increase of salinity at 20℃.Moreover,the adsorption of gel-breaking fluids on the rock decreased first and then kept stable with temperature increasing at a salinity of ≤30,000 mg/L,however,showed the opposite trend at 40,000 mg/L.The results of rheology,particle size,static adsorption,and core damage showed that this functional FF could be an alternative for the stimulation of a tight reservoir with high temperature and recycling of produced water with high salinity.

Application of Newtonian approximate model to LIGO gravitational wave data processing

With the observation of a series of ground-based laser interferometer gravitational wave(GW)detectors such as LIGO and Virgo,nearly 100 GW events have been detected successively.At present,all detected GW events are generated by the mergers of compact binary systems and are identified through the data processing of matched filtering.Based on matched filtering,we use the GW waveform of the Newtonian approximate(NA)model constructed by linearized theory to match the events detected by LIGO and injections to determine the coalescence time and utilize the frequency curve for data fitting to estimate the parameters of the chirp masses of binary black holes(BBHs).The average chirp mass of our results is 22.05_(-6.31)^(+6.31)M_(⊙),which is very close to 23.80_(-3.52)^(+4.83)M_(⊙)provided by GWOSC.In the process,we can analyze LIGO GW events and estimate the chirp masses of the BBHs.This work presents the feasibility and accuracy of the low-order approximate model and data fitting in the application of GW data processing.It is beneficial for further data processing and has certain research value for the preliminary application of GW data.

Coexistence of giant Rashba spin splitting and quantum spin Hall effect in H–Pb–F

Rashba spin splitting(RSS)and quantum spin Hall effect(QSHE)have attracted enormous interest due to their great significance in the application of spintronics.In this work,we theoretically proposed a new two-dimensional(2D)material H–Pb–F with coexistence of giant RSS and quantum spin Hall effec by using the ab initio calculations.Our results show that H–Pb–F possesses giant RSS(1.21 eV·A)and the RSS can be tuned up to 4.16 e V·A by in-plane biaxial strain,which is a huge value among 2D materials.Furthermore,we also noticed that H–Pb–F is a 2D topological insulator(TI)duo to the strong spin–orbit coupling(SOC)interaction,and the large topological gap is up to 1.35 e V,which is large enough for for the observation of topological edge states at room temperature.The coexistence of giant RSS and quantum spin Hall effect greatly broadens the potential application of H–Pb–F in the field of spintronic devices.

Differential expression and significance of 5-hydroxymethylcytosine modification in hepatitis B virus carriers and patients with liver cirrhosis and liver cancer

BACKGROUND The relationship between hepatitis B surface antigen(HBsAg)-positive carrier status and liver cancer has been extensively studied.However,the epigenetic changes that occur during progression from HBsAg-positive carrier status or cirrhosis to liver cancer are unknown.The epigenetic modification of DNA hydroxymethylation is critical in tumor development.Further,5-hydroxymethylcytosine(5hmC)is an important base for DNA demethylation and epigenetic regulation.It is also involved in the assembly of chromosomes and the regulation of gene expression.However,the mechanism of action of 5hmC in HBsAgpositive carriers or patients with cirrhosis who develop liver cancer has not been fully elucidated.AIM To investigate the possible epigenetic mechanism of HBsAg-positive carriers and hepatocellular carcinoma(HCC)progression from cirrhosis.METHODS Forty HBsAg-positive carriers,forty patients with liver cirrhosis,and forty patients with liver cancer admitted to the First People's Hospital of Yongkang between March 2020 and November 2021 were selected as participants.Free DNA was extracted using a cf-DNA kit.cfDNA was extracted by 5hmC DNA sequencing for principal component analysis,the expression profiles of the three groups of samples were detected,and the differentially expressed genes(DEGs)modified by hydroxymethylation were screened.Bioinformatic analysis was used to enrich DEGs,such as in biological pathways.RESULTS A total of 16455 hydroxymethylated genes were identified.Sequencing results showed that 32 genes had significant 5hmC modification differences between HBsAg carriers and liver cancer patients,of which 30 were upregulated and 2 downregulated in patients with HCC compared with HBsAg-positive carriers.Significant 5hmC modification differences between liver cirrhosis and liver cancer patients were identified in 20 genes,of which 17 were upregulated and 3 were downregulated in patients with HCC compared with those with cirrhosis.These genes may have potential loci that are undiscovered or unelucidated,which contribute to the development and progression of liver cancer.Analysis of gene ontology enrichment and Kyoto Encyclopedia of Genes and Genomes showed that the major signaling pathways involved in the differential genes were biliary secretion and insulin secretion.The analysis of protein interactions showed that the important genes in the protein-protein interaction network were phosphoenolpyruvate carboxykinase and solute carrier family 2.CONCLUSION The occurrence and development of liver cancer involves multiple genes and pathways,which may be potential targets for preventing hepatitis B carriers from developing liver cancer.

铁路隧道爆破对临近特高压铁塔的振动影响研究

为研究隧道爆破开挖对临近既有特高压铁塔的影响,本文采用现场试验和数值模拟相结合的方法,对铁塔塔基的振动速度进行研究,并且详细讨论了爆心距与振动速度峰值的关系。通过数据拟合,得出本工程条件下隧道爆破质点的振动传播规律及衰减公式。结果表明:塔基的振动速度峰值随爆源与塔基距离的接近而增大,在爆心距为0 m时出现最大振速;竖直方向的振速普遍高于水平方向的振速;三座铁塔最大轴应力均出现在塔基处,最大轴应力随铁塔高度的增加而逐渐减小。数值模拟结果与现场试验结果相近,研究可为实际工程提供参考依据。

Brain-derived neurotrophic factor, sex hormones and cognitive decline in male patients with schizophrenia receiving continuous antipsychotic therapy

BACKGROUND There are systematic differences in clinical features between women and men with schizophrenia(SCZ).The regulation of sex hormones may play a potential role in abnormal neurodevelopment in SCZ.Brain-derived neurotrophic factor(BDNF)and sex hormones have complex interacting actions that contribute to the etiology of SCZ.AIM To investigate the influence of BDNF and sex hormones on cognition and clinical symptomatology in chronic antipsychotic-treated male SCZ patients.METHODS The serum levels of follicle-stimulating hormone,luteinizing hormone(LH),estradiol(E2),progesterone,testosterone(T),prolactin(PRL)and BDNF were compared between chronic antipsychotic-treated male(CATM)patients with SCZ(n=120)and healthy controls(n=120).The Positive and Negative Syndrome Scale was used to quantify SCZ symptoms,while neuropsychological tests were used to assess cognition.Neuropsychological tests,such as the Digit Cancellation Test(DCT),Semantic Verbal Fluency(SVF),Spatial Span Test(SS),Paced Auditory Serial Addition Test(PASAT),Trail Making Task(TMT-A),and Block Design Test(BDT),were used to assess executive functions(BDT),attention(DCT,TMT-A),memory(SS,PASAT),and verbal proficiency(SVF).RESULTS Although E2 levels were significantly lower in the patient group compared to the healthy controls,T,PRL,and LH levels were all significantly higher.Additionally,the analysis revealed that across the entire sample,there were positive correlations between E2 Levels and BDNF levels as well as BDNF levels and the digital cancellation time.In CATM patients with SCZ,a significant correlation between the negative symptoms score and PRL levels was observed.CONCLUSION Sex hormones and BDNF levels may also be linked to cognitive function in patients with chronic SCZ.

Associations between Borg's rating of perceived exertion and changes in urinary organic acid metabolites after outdoor weightbearing hiking

BACKGROUND Developing methods to monitor exercise load and evaluate body fatigue and muscle injury over time in hiking training remains a key problem to be solved.A widely used psycho-physical tool to assess the subjective perception of effort during exercise is Borg’s rating of perceived exertion(BRPE)scale.Data on the relationships and validity of the BRPE compared to objectively assessed metabolic criteria are still lacking,especially urinary organic acid concentrations.AIM To verify whether the BRPE scale could be used in the prescription of outdoor hiking with weight-bearing and reveal the relationship between the BRPE scale and urinary physiological measures.METHODS Eighty-nine healthy men(average age:22 years)were enrolled in a 40 km(6 h)hiking training exercise with a 20 kg load.After training,the BRPE scale(6-20)was completed.All participants were divided into three groups according to the rating of the BRPE scale.Urine samples were collected before and after training.Urinary myoglobin levels were measured immediately using the fluorescent immunoassay method.The remaining urine was subpacked and frozen for the subsequent detection of urinary organic acids using gas chromatography and mass spectrometry.RESULTS The contents of organic acids and myoglobin in urine were significantly increased after participants hiked 40 km(6 h)with a 20 kg load.Only orthogonal partial least-squares discrimination analysis performed well in separating the group with a BRPE score of 6-12 from the group with a BRPE score of 13-20.Significant differences in the urine levels of several organic acids were observed between the two groups,and the heatmap also presented different metabolic profiles based on BRPE.According to the standard of a variable importance in the projection>1,fold change>1.5 and P<0.05,19 different metabolites of urinary organic acids were screened and enriched in pathways mainly including the citrate cycle(tricarboxylic acid cycle)and alanine,aspartate and glucose metabolism.CONCLUSION The BRPE scale identified significantly different urinary organic acid profiles between the higher and lower BRPE value groups,and,thus,could be used to monitor body fatigue in individuals participating in long-distance outdoor hiking with weight bearing.

环金属配体Ir(Ⅲ)配合物结构、光谱和量子效率的理论研究

对一类环金属Ir(Ⅲ)[(C^N)_(2)Ir(A^A)]配合物[C^N=ptaz(1,2,4),mhtz(3),ptaz=3,4,5-三苯基-4H-1,2,4-三唑,mhtz=1,3-双甲基-5-苯基-1H-1,2,4-三唑;A^A=pzpy(1),npzpy(2,3),bicb(4),pzpy=2-(1H-吡唑-1-基)吡啶,npzpy=4-二甲基氨基-2-(1H-吡唑-1-基)吡啶,bicb=3,3′-亚甲基双(1-甲基-1H-咪唑-2-亚基)]的结构、光谱特征和磷光量子效率进行了理论研究.计算方法探究表明,基于B3LYP泛函优化的基态结构和单激发组态相互作用(CIS)方法得到的激发态结构计算的吸收和发射光谱更准确.配合物1~4的最低吸收峰和发射峰分别位于408,376,382,365 nm和503,506,468,511 nm处,其HOMOs主要由金属和C^N配体占据,而配合物1~3的LUMOs由A^A配体的π反键轨道组成,配合物4的LUMO存在于C^N配体上.因此,配合物4的最低吸收峰和发射峰具有与配合物1~3不同的金属到配体和配体内部(MLCT/ILCT)的混合跃迁性质,非共轭N^N配体的引入显著消弱了其在跃迁过程中的贡献程度.配合物1~4的量子效率取决于非辐射跃迁速率常数k_(nr),这与它们重组能的贡献[4569 cm^(-1)(3)>2583 cm^(-1)(1)>1232 cm^(-1)(2)>975 cm^(-1)(4)]相一致,表明主配体的体积和辅助配体的共轭能力都能影响配合物的磷光量子效率.

光栅MOEMS加速度计温度特性

由于硅微机械加速度计受温度影响,导致硅弹性模量和热膨胀系数发生变化,造成微光机电系统(MOEMS)加速度计标度因数漂移、测量稳定性下降等问题。首先,采用COMSOL软件对光栅MOEMS加速度计微机械结构部分进行了温度特性仿真,分析了硅弹性模量温度系数和热膨胀系数对光栅MOEMS加速度计微机械结构标度因数和零位的影响。其次,设计了温控精度达0.1℃的温度控制系统,并利用该系统对加速度计进行温度控制。最后,对光栅泰伯效应MOEMS加速度计温度特性展开测试,结果表明,加速度计的标度因数随温度升高而增大,零偏稳定性随温度的升高而降低,加速度计标度因数温度系数为0.30 V·g^(-1)·℃^(-1),零偏稳定性温度系数为-7.78μg/℃,其变化趋势与仿真结果一致。这为实现全温范围下高精度MOEMS加速度计奠定了基础。

三维解剖联合QLAB在超声医学教学中的应用实践

目的 评估三维解剖投影联合QLAB(quantitative light analysisand beamforming)在超声医学教学中的应用价值。方法 本次研究选取天水市第一人民医院超声科2016年6月—2020年12月的实习生、专科医师规范化培训(简称专培)学生80名,采用随机数字法将其分为试验组和对照组,各40名。试验组采用传统教学法,对照组采用三维解剖投影联合QLAB软件教学法。学习结束后,分别对2组学生超声解剖图像辨识考核和问卷调查,比较2组教学方法的效果。结果 试验组满意度(95%)高于对照组(75%),差异有统计学意义(P <0.05)。试验组超声解剖图像辨识率(95%)高于对照组(70%),差异有统计学意义(P <0.05)。结论 三维解剖联合QLAB在超声医学教学更加规范、更加系统、更加完善,有利于提高教学满意度、超声解剖图像辨识率,增强学习兴趣。

微纳光栅MOEMS加速度计优化设计与测试

提出了一种基于微纳光栅泰伯效应的微光机电系统(MOEMS)加速度计,通过Comsol软件对加速度计结构和光栅结构参数进行优化,使其在20g量程范围内获得较大的结构灵敏度和衍射效应灵敏度,同时通过仿真分析了该结构的交叉轴串扰情况。由于受外界温度起伏影响,双层光栅结构间距受热膨胀系数的影响产生相对位移。为了减小由于温度起伏对光栅加速度计零偏的影响,采用温度闭环反馈控制技术将加速度计温度变化控制在±10 mK范围内。经实验测试,加速度计零偏稳定性达3.7μg,相较于无温控情况提升了近7倍。最终实现光栅MOEMS加速度计的灵敏度达5.23 V/g,线性相关系数为99.9%,分辨率达286.8μg。