Highly sensitive and reliable detection of multiple myeloma remains a major challenge in liquid biopsy. Herein, for the first time, quantum dot-molecular beacon (QD-MB) functionalized MoS_(2) (QD-MB @MoS_(2)) fluoresc...Highly sensitive and reliable detection of multiple myeloma remains a major challenge in liquid biopsy. Herein, for the first time, quantum dot-molecular beacon (QD-MB) functionalized MoS_(2) (QD-MB @MoS_(2)) fluorescent probes were designed for the dual detection of multiple myeloma (MM)-related miRNA-155 and miRNA-150. The results indicate that the two probes can effectively detect miRNA-155 and miRNA-150 simultaneously with satisfactory recovery rates, and the limit of detections (LODs) of miRNA-155 and miRNA-150 in human serum are low to 7.19 fM and 5.84 fM, respectively. These results indicate that our method is the most sensitive detection so far reported and that the designed fluorescent probes with signal amplification strategies can achieve highly sensitive detection of MM-related miRNAs for MM diagnosis.展开更多
We calculate the dimensions of Bott–Chern and Aeppli cohomologies associated to a complex structure on S^(3)×S^(3).We express them in terms mainly of Hogde numbers.
Two-dimensional transition metal dichalcogenides are considered promising materials for next-generation photonics and nano-optical devices. Although many previous reports have shown saturable absorption of molybdenum ...Two-dimensional transition metal dichalcogenides are considered promising materials for next-generation photonics and nano-optical devices. Although many previous reports have shown saturable absorption of molybdenum diselenide(Mo Se2), these nonlinear optical(NLO) properties of Mo Se2 were measured in separate works and under different conditions with their hot-carrier relaxations. Here, we conducted a series of coherent studies on the NLO properties of few-layer Mo Se2 via open-aperture Z-scan and degenerate pump-probe techniques. These measurements were taken to test the materials' capabilities as a slow-saturable absorber. A slowabsorber model was employed to analyze the NLO measurements, and the results show that the NLO modulation depth was modeled to be 7.4% and 15.1% for the linear absorption coefficients of 5.22 cm-1 and 6.51 cm-1,respectively. The corresponding saturated intensities were modeled to be 39.37 MW∕cm2 and 234.75 MW∕cm2,respectively. The excitation carrier recovery time of few-layer Mo Se2 was measured by degenerate pump-probe techniques to be ～220 ps. These nonlinear optical performances make it a promising slow-saturable absorber for passive mode locking in femtosecond lasers.展开更多
基金The authors acknowledge the generous financial support from the National Natural Science Foundation of China(61971207,61975070,51902143,61775088)Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD),Key Research and Development Project of Jiangsu Province(BE2018062,BE2019033)+6 种基金Natural Science Foundation of Jiangsu Province(BK20191467)Post-graduate Research&Practice Innovation Program of Jiangsu Province(KYCX20_2229)International S&T Cooperation Program of Jiangsu Province(BZ2019063,BZ2020045,BZ2020030)Natural Science Foundation of the Jiangsu Higher Education Institutes of China(19KJB430018,20KJA430003)Special Project for Technology Innovation of Xuzhou City(KC19250,KC20201,KC20244)Open Project of State Key Laboratory of Advanced Materials and Electronic Components(FHR-JS-202011017)We also thank Dr.Zhiling Yan for his help and support on the collection of blood samples.WC would like to thank the support from Solgro Inc.,Guangxi Jialouyuan Medical Inc.and UT Arlington distinguished award.
文摘Highly sensitive and reliable detection of multiple myeloma remains a major challenge in liquid biopsy. Herein, for the first time, quantum dot-molecular beacon (QD-MB) functionalized MoS_(2) (QD-MB @MoS_(2)) fluorescent probes were designed for the dual detection of multiple myeloma (MM)-related miRNA-155 and miRNA-150. The results indicate that the two probes can effectively detect miRNA-155 and miRNA-150 simultaneously with satisfactory recovery rates, and the limit of detections (LODs) of miRNA-155 and miRNA-150 in human serum are low to 7.19 fM and 5.84 fM, respectively. These results indicate that our method is the most sensitive detection so far reported and that the designed fluorescent probes with signal amplification strategies can achieve highly sensitive detection of MM-related miRNAs for MM diagnosis.
文摘We calculate the dimensions of Bott–Chern and Aeppli cohomologies associated to a complex structure on S^(3)×S^(3).We express them in terms mainly of Hogde numbers.
基金Science Foundation Ireland(SFI)(12/IA/1306)Seventh Framework Programme(FP7)(ISLA project no.287732)+4 种基金National Natural Science Foundation of China(NSFC)(61522510,61675217,11704261,11575118)Strategic Priority Research Program of Chinese Academy of Sciences(CAS)(XDB16030700)Key Research Program of Frontier Science of Chinese Academy of Sciences(QYZDBSSW-JSC041)the Program of Shanghai Academic Research Leader(17XD1403900)Shenzhen Key Lab Fund(ZDSYS20170228105421966)
文摘Two-dimensional transition metal dichalcogenides are considered promising materials for next-generation photonics and nano-optical devices. Although many previous reports have shown saturable absorption of molybdenum diselenide(Mo Se2), these nonlinear optical(NLO) properties of Mo Se2 were measured in separate works and under different conditions with their hot-carrier relaxations. Here, we conducted a series of coherent studies on the NLO properties of few-layer Mo Se2 via open-aperture Z-scan and degenerate pump-probe techniques. These measurements were taken to test the materials' capabilities as a slow-saturable absorber. A slowabsorber model was employed to analyze the NLO measurements, and the results show that the NLO modulation depth was modeled to be 7.4% and 15.1% for the linear absorption coefficients of 5.22 cm-1 and 6.51 cm-1,respectively. The corresponding saturated intensities were modeled to be 39.37 MW∕cm2 and 234.75 MW∕cm2,respectively. The excitation carrier recovery time of few-layer Mo Se2 was measured by degenerate pump-probe techniques to be ～220 ps. These nonlinear optical performances make it a promising slow-saturable absorber for passive mode locking in femtosecond lasers.
