Microwave ablation(MWA)status monitoring in real time plays a key role in assessment of therapeutic fectiveness.As a novel realtime assessment method,near infrared spectroscopy(NIRs)was used to evaluate the ablation e...Microwave ablation(MWA)status monitoring in real time plays a key role in assessment of therapeutic fectiveness.As a novel realtime assessment method,near infrared spectroscopy(NIRs)was used to evaluate the ablation eficacy.MWA experiments were carried out on in vitroporcine livers.An optical measurement system for biological tissue is developed by our lab tomonitor reduced scattering coefficient(μ')at 690 nm of the coagulation zones.It is noted that p's of liver tissue,which increases as the liver tissue being ablated,is clearly related with the co-agulation status.μ's of normal tissue and coagulated tissue is 3-5 and 17-19 cm-1,respectively.Continuous changes ofμ's demonstrate that optical parameter can be used as an efficacy evaluation factor because it essentially indicates the degree of thermal damage.Compared withtemperat ure,optical parameter is more sensitive and accurate,which is promising for real-timetherapeutic eficacy assessment in MWA.展开更多
基金part of the project 61378092 supported by NSFC and also funded by the construction,project,"Microwave Ablation Clinical Application Exploration in the Comprehensive Treatment of Cancer",based on the researchplat form of the Afiliated Tumor Hospital of Xiangya Medical College,Central South Universitythe Funding of Jiangsu Innovation Program for Graduate Education(No.CXLX13_147)the Fundamental Research Funds for the Central Universities.
文摘Microwave ablation(MWA)status monitoring in real time plays a key role in assessment of therapeutic fectiveness.As a novel realtime assessment method,near infrared spectroscopy(NIRs)was used to evaluate the ablation eficacy.MWA experiments were carried out on in vitroporcine livers.An optical measurement system for biological tissue is developed by our lab tomonitor reduced scattering coefficient(μ')at 690 nm of the coagulation zones.It is noted that p's of liver tissue,which increases as the liver tissue being ablated,is clearly related with the co-agulation status.μ's of normal tissue and coagulated tissue is 3-5 and 17-19 cm-1,respectively.Continuous changes ofμ's demonstrate that optical parameter can be used as an efficacy evaluation factor because it essentially indicates the degree of thermal damage.Compared withtemperat ure,optical parameter is more sensitive and accurate,which is promising for real-timetherapeutic eficacy assessment in MWA.
