Objective: To determine if short-term treatment with Femara (letrozole) induces measurable reduction in tumor Ki67 expression in postmenopausal women with FIGO grade 1 and 2 endometrial carcinoma. Methods: In this non...Objective: To determine if short-term treatment with Femara (letrozole) induces measurable reduction in tumor Ki67 expression in postmenopausal women with FIGO grade 1 and 2 endometrial carcinoma. Methods: In this non-randomized prospective study, 12 patients were given Femara (letrozole) 2.5 mg daily for approximately 3 weeks prior to planned hysterectomy for FIGO grade 1 or 2 endometrial carcinoma. A group of 12 demographically similar patients were enrolled as no-treatment controls. Ki67 expression in tumor cells was quantitated by immunohistochemistry with mechanical scanning within the initial endometrial biopsy and compared to that in the hysterectomy specimen for each patient in the treatment and control groups. Results: The treatment and control groups were similar in age, tumor grade and FIGO stage. When “aromatase inhibitor responsiveness” was defined as proportionate decline in Ki67% stained tumor cells of at least 70% between the pre-treatment endometrial biopsy and post-treatment hysterectomy specimens, 5 of 12 patients were found to be “responsive” in the treatment group with none of the controls fulfilling these criteria. Conclusion: Femara (letrozole) 2.5 mg daily for approximately 3 weeks induced a significant reduction in tumor cell Ki67 expression among 5 of 12 (41%) postmenopausal women with FIGO grade 1 or 2 endometrial carcinoma. We postulate that Ki67 may be a useful marker during aromatase inhibitor medical treatment of patients with endometrial cancer who are not candidates for surgical treatment.展开更多
When Marine Ma founded social networking and Internet dating firm eFriendsNet Entertainment Corp. in late 2003, the company didn＇t even have an operating website. What the Beijing native and veteran of NASDAQ-listed ...When Marine Ma founded social networking and Internet dating firm eFriendsNet Entertainment Corp. in late 2003, the company didn＇t even have an operating website. What the Beijing native and veteran of NASDAQ-listed internet portal Netease.com did have was US$1.8 million in investment, a team from a previously failed venture, and a conviction that Chinese singles were ready to find true love online.展开更多
Venture capitalists seeking their fortunes in China have clearly heard the buzz about Web 2.0 - and they＇re voting with their pocketbooks. A recent study by international services firm Ernst ＆ Young found that secon...Venture capitalists seeking their fortunes in China have clearly heard the buzz about Web 2.0 - and they＇re voting with their pocketbooks. A recent study by international services firm Ernst ＆ Young found that second-quarter investment in ＂information services,＂ including blogs, social networks, wikis and other Web 2.0 companies, doubled from the first quarter to USD 209 million.展开更多
文摘Objective: To determine if short-term treatment with Femara (letrozole) induces measurable reduction in tumor Ki67 expression in postmenopausal women with FIGO grade 1 and 2 endometrial carcinoma. Methods: In this non-randomized prospective study, 12 patients were given Femara (letrozole) 2.5 mg daily for approximately 3 weeks prior to planned hysterectomy for FIGO grade 1 or 2 endometrial carcinoma. A group of 12 demographically similar patients were enrolled as no-treatment controls. Ki67 expression in tumor cells was quantitated by immunohistochemistry with mechanical scanning within the initial endometrial biopsy and compared to that in the hysterectomy specimen for each patient in the treatment and control groups. Results: The treatment and control groups were similar in age, tumor grade and FIGO stage. When “aromatase inhibitor responsiveness” was defined as proportionate decline in Ki67% stained tumor cells of at least 70% between the pre-treatment endometrial biopsy and post-treatment hysterectomy specimens, 5 of 12 patients were found to be “responsive” in the treatment group with none of the controls fulfilling these criteria. Conclusion: Femara (letrozole) 2.5 mg daily for approximately 3 weeks induced a significant reduction in tumor cell Ki67 expression among 5 of 12 (41%) postmenopausal women with FIGO grade 1 or 2 endometrial carcinoma. We postulate that Ki67 may be a useful marker during aromatase inhibitor medical treatment of patients with endometrial cancer who are not candidates for surgical treatment.
文摘When Marine Ma founded social networking and Internet dating firm eFriendsNet Entertainment Corp. in late 2003, the company didn＇t even have an operating website. What the Beijing native and veteran of NASDAQ-listed internet portal Netease.com did have was US$1.8 million in investment, a team from a previously failed venture, and a conviction that Chinese singles were ready to find true love online.
文摘Venture capitalists seeking their fortunes in China have clearly heard the buzz about Web 2.0 - and they＇re voting with their pocketbooks. A recent study by international services firm Ernst ＆ Young found that second-quarter investment in ＂information services,＂ including blogs, social networks, wikis and other Web 2.0 companies, doubled from the first quarter to USD 209 million.
