Advances in Research on Anticancer Properties of Salidroside

Salidroside is a phenolic secondary metabolite present in plants of the genus Rhodiola,and studies investigating its extensive pharmacological activities and mechanisms have recently attracted increasing attention.This review summarizes the progress of recent research on the antiproliferative activities of salidroside and its effects on breast,ovarian,cervical,colorectal,lung,liver,gastric,bladder,renal,and skin cancer as well as gliomas and fibrosarcomas.Thus,it provides a reference for the further development and utilization of salidroside.

黄嘌呤氧化酶抑制剂非布司他衍生物的研究进展

黄嘌呤氧化酶抑制剂非布司他是经典的抗痛风药物,治疗效果显著且耐受性好。非布司他及其衍生物在结构上可以分为两个主要部分,分别为取代苯环和羧基取代的五元或六元杂环。本文综述了近10年来非布司他衍生物的研究进展,针对各类衍生物的构效关系进行了分类概述。探究黄嘌呤氧化酶抑制剂的作用机制和构效关系,对合理设计和开发抗痛风的新化学实体具有十分重要的意义。