调控等级孔UiO-66(Ce)中Ru纳米团簇的电子态、丰度和微环境用于高效催化双环戊二烯加氢

催化石油加工副产物双环戊二烯(DCPD)加氢得到的四氢双环戊二烯(THDCPD)是一种高能量密度燃料,在航空航天领域具有重要应用价值.传统DCPD加氢催化剂在反应中存在使用寿命短和重复使用性差等问题.金属有机框架(MOFs)作为一种周期有序多孔材料,有望成为用于DCPD加氢的新型高效催化剂.通过引入介孔或大孔来构建等级孔MOFs(HP-MOFs),可以克服微孔对DCPD等大客体分子的扩散限制,促进底物分子向HP-MOFs内部活性位点转移.此外,加入合适的金属组分(如价格相对低廉的Ru)到HP-MOFs,可以使金属的原子利用率最大化,优化活性位点的分散性和稳定性,进一步协同提升催化性能.因此,发展HP-MOFs与金属组分间异质结构的调控方法,建立构效关系至关重要.本文采用软模板法制备了HP-UiO-66(Ce),设计和构建了介孔UiO-66(Ce)负载钌纳米簇(NCs)异质材料,并用于催化DCPD加氢反应.X射线衍射(XRD)、扫描电镜、透射电镜、氮气吸脱附和DCPD加氢结果表明,与微孔和大孔UiO-66(Ce)相比,介孔UiO-66(Ce)独特的结构在催化剂制备和DCPD加氢中显示出独特的优势:(1)具有配体缺失缺陷的Ce-oxo簇促进了Ru^(3+)的有效吸附;(2)微孔框架的约束作用实现了Ru NCs的有效固定和均匀分散,抑制了Ru NCs的团聚和流失,保证了催化剂的稳定性;(3)介孔结构为DCPD和H_(2)底物分子提供了高效的传质通道,也有利于暴露更多的活性中心,促进DCPD与H_(2)底物分子的吸附和活化.此外,通过优化合成条件,可以精确控制Ru NCs活性位点的电子结构、分布和微环境.XRD和X射线光电子能谱结果表明,Ru NCs和Meso-UiO-66(Ce)之间Ru-O-Ce强异质界面的形成导致了晶格畸变,Ru@Meso-UiO-25-200中Ru^(0)和M-O占比最多,主要来源于还原处理得到的Ru NCs和Ru-O-Ce异质界面中Ru‒O键的形成,且样品中Ru0的含量与Ru^(3+)吸附温度呈反相关趋势,与样品还原温度呈正相关趋势.密度泛函理论计算结果表明,金属Ru0作为主要活性位点,极大地促进了DCPD和H2的吸附,并激活了催化剂上吸附的DCPD的C=C键,促进了DCPD两个C=C双键的“共吸附”和连续化加氢过程.因此,介孔UiO-66(Ce)和Ru NCs异质结构的构建,在低温(60℃)下仅用35 min就实现了DCPD催化加氢得到四氢双环戊二烯(THDCPD)(100%转化率和~100%选择性),且循环使用6次后性能基本保持不变,表现出较好的活性和稳定性.综上,本文通过等级孔和异质结构的构筑,证明了介孔结构在大底物分子催化反应中的结构优越性,并进一步揭示了催化剂合成条件、结构和性能之间的关系,为理性设计新型MOFs基功能材料在催化、吸附、储能等方面的应用提供新思路.

Unraveling colorectal cancer prevention:The vitamin D-gut flora-immune system nexus

Colorectal cancer(CRC)is one of the most common cancers diagnosed in the world.Although environmental and genetic factors play a major role in the pathogenesis of CRC,extensive research has suggested that vitamin D may play a pivotal role in the development of CRC.Vitamin D,primarily obtained through sunlight exposure,dietary sources,and supplements,has long been recognized for its essential functions in maintaining health,including immune regulation.This article delves into the intricate relationship between vitamin D,the immune system,gut flora,and the prevention of CRC.It presents a synthesis of epidemiological data,experimental studies,and clinical trials,highlighting the mechanisms by which vitamin D influences immune cell function,cytokine production,and inflammation.By enhancing the immune system’s surveillance and antitumor activity,vitamin D may offer a promising avenue for CRC prevention.Furthermore,this comprehensive review delves into the prospective clinical applications of vitamin D supplementation and delineates the forthcoming avenues of research in this dynamic domain.Additionally,the paper tentatively outlines a spectrum of prophylactic impacts of vitamin D on CRC,emphasizing its significant potential in reducing CRC risk through shedding light on its mechanisms,encompassing antineoplastic mechanisms,influences on the immune system,and modulation of the gut microbiome.

Protective mechanism of quercetin in alleviating sepsis-related acute respiratory distress syndrome based on network pharmacology and in vitro experiments

BACKGROUND:Sepsis-related acute respiratory distress syndrome(ARDS)has a high mortality rate,and no effective treatment is available currently.Quercetin is a natural plant product with many pharmacological activities,such as antioxidative,anti-apoptotic,and anti-inflammatory effects.This study aimed to elucidate the protective mechanism of quercetin against sepsis-related ARDS.METHODS:In this study,network pharmacology and in vitro experiments were used to investigate the underlying mechanisms of quercetin against sepsis-related ARDS.Core targets and signaling pathways of quercetin against sepsis-related ARDS were screened and were verified by in vitro experiments.RESULTS:A total of 4,230 targets of quercetin,360 disease targets of sepsis-related ARDS,and 211 intersection targets were obtained via database screening.Among the 211 intersection targets,interleukin-6(IL-6),tumor necrosis factor(TNF),albumin(ALB),AKT serine/threonine kinase 1(AKT1),and interleukin-1β(IL-1β)were identified as the core targets.A Gene Ontology(GO)enrichment analysis revealed 894 genes involved in the inflammatory response,apoptosis regulation,and response to hypoxia.Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analysis identified 106 pathways.After eliminating and generalizing,the hypoxia-inducible factor-1(HIF-1),TNF,nuclear factor-κB(NF-κB),and nucleotide-binding and oligomerization domain(NOD)-like receptor signaling pathways were identified.Molecular docking revealed that quercetin had good binding activity with the core targets.Moreover,quercetin blocked the HIF-1,TNF,NF-κB,and NODlike receptor signaling pathways in lipopolysaccharide(LPS)-induced murine alveolar macrophage(MH-S)cells.It also suppressed the inflammatory response,oxidative reactions,and cell apoptosis.CONCLUSION:Quercetin ameliorates sepsis-related ARDS by binding to its core targets and blocking the HIF-1,TNF,NF-κB,and NOD-like receptor signaling pathways to reduce inflammation,cell apoptosis,and oxidative stress.

Jianqu,a traditional Chinese medicine,alleviates functional dyspepsia in high-calorie and high-protein diet mice

Background:Jianqu has been used to alleviate symptoms in patients with functional dyspepsia,but its specific anti-functional dyspepsia effect is still unclear.Therefore,our study aimed to investigate the impact of Jianqu on functional dyspepsia in mice.Methods:The phytochemical profile of Jianqu was analyzed by UPLC-Q-TOF-MS.Subsequently,Kunming mice were fed a high-calorie or high-protein diet(HCHP)for 7 days,and then orally treated with vehicle or Jianqu(1.62 g/kg body weight(b.w.)and 3.25 g/kg b.w.)for 10 days.A carbon powder solution was used to detect the gastric emptying and intestinal transit rate.The pathological changes in stomach and duodenum were evaluated by hematoxylin-eosin staining.The occludin,claudin-1,ZO-1 and CD45 expression was measured by immunocytochemical staining.Importantly,the serum gastrointestinal hormones were detected by ELISA.In addition,the gut microbiota composition was determined using 16S rRNA gene sequencing.The cecal short chain fatty acids were assessed by gas chromatography.Results:In general,17 phytochemical compounds were identified from Jianqu,which significantly improved the gastric emptying rate and intestinal transit rate(p<0.01),increased the body weight and food intake(p<0.0001)in HCHP mice as well.Though HCHP did not cause significant pathological lesions in the gastrointestinal tract,increased the expression of CD45 in the duodenum(p<0.05)was observed.Notably,Jianqu attenuated this abnormal expression of CD45(p<0.05).The levels of serum gastrointestinal hormones were significantly normalized by Jianqu intervention(p<0.05).Moreover,Jianqu increased the relative abundance of Roseburia as well as short chain fatty acids levels in cecum(p<0.05).Conclusion:The present results showed that Jianqu alleviated dyspeptic symptoms in HCHP mice possibly through reducing the duodenal leukocyte infiltration,and regulating the expression of gastrointestinal hormones.These effects may be partly related to the increasing cecal short chain fatty acids levels probably via gut microbial modulation.

Social-ecological perspective on the suicidal behaviour factors of early adolescents in China:a network analysis

Background In early adolescence,youth are highly prone to suicidal behaviours.Identifying modifiable risk factors during this critical phase is a priority to inform effective suicide prevention strategies.Aims To explore the risk and protective factors of suicidal behaviours(ie,suicidal ideation,plans and attempts)in early adolescence in China using a social-ecological perspective.Methods Using data from the cross-sectional project‘Healthy and Risky Behaviours Among Middle School Students in Anhui Province,China',stratified random cluster sampling was used to select 5724 middle school students who had completed self-report questionnaires in November 2020.Network analysis was employed to examine the correlates of suicidal ideation,plans and attempts at four levels,namely individual(sex,academic performance,serious physical llness/disability,history of self-harm,depression,impulsivity,sleep problems,resilience),family(family economic status,relationship with mother,relationship with father,family violence,childhood abuse,parental mental illness),school(relationship with teachers,relationship with classmates,school-bullying victimisation and perpetration)and social(social support,satisfaction with society).Results In total,37.9%,19.0%and 5.5%of the students reported suicidal ideation,plans and attempts in the past 6 months,respectively.The estimated network revealed that suicidal ideation,plans and attempts were collectively associated with a history of self-harm,sleep problems,childhood abuse,school bullying and victimisation.Centrality analysis indicated that the most influential nodes in the network were history of self-harm and childhood abuse.Notably,the network also showed unique correlates of suicidal ideation(sex,weight=0.60;impulsivity,weight=0.24;family violence,weight=0.17;relationship with teachers,weight=-0.03;school-bullying perpetration,weight=0.22),suicidal plans(social support,weight=-0.15)and suicidal attempts(relationship with mother,weight=-0.10;parental mental llness,weight=0.61).Conclusions This study identified the correlates of suicidal ideation,plans and attempts,and provided practical implications for suicide prevention for young adolescents in China.Firstly,this study highlighted the importance of joint interventions across multiple departments.Secondly,the common risk factors of suicidal ideation,plans and attempts were elucidated.Thirdly,this study proposed target interventions to address the unique influencing factors of suicidal ideation,plans and attempts.

Clinical Observation on the Treatment of Diabetic Kidney Disease with Damp-heat Stasis Syndrome in Clinical Proteinuria Stage by Kunkui Kidney Preserving Paste

[Objectives]To evaluate the clinical efficacy and safety of Kunkui Kidney Preserving Paste in the treatment of diabetic kidney disease(DKD)patients with damp-heat stasis syndrome in the clinical proteinuria stage.[Methods]Retrospective analysis was made on 30 patients with DKD who were diagnosed with damp-heat stasis syndrome in the clinical proteinuria stage from March 2021 to March 2023 in Jiangsu Province Hospital of Chinese Medicine,and who took Kunkui Kidney Preserving Paste continuously for six months.The urinary albumin/creatinine ratio(UACR),urinary complement C3,and urea nitrogen(BUN)of DKD patients before and after treatment were compared,and estimated glomerular filtration rate(eGFR),blood creatinine(Scr),and cystatin C(CysC)were estimated,and the therapeutic effects on renal function and urinary protein were evaluated.[Results]After treatment,UACR significantly decreased(P<0.01),and urinary complement C3 and Scr decreased(P<0.05),while other indicators showed no significant statistical difference(P>0.05).In terms of evaluating the efficacy of urinary protein therapy,8 cases showed recent relief;8 cases showed significant effect;9 cases were effective,and 5 cases were invalid after treatment,with a total effective rate of 83.33%.In terms of renal function efficacy evaluation,8 cases showed significant effect;4 cases were effective;11 cases were stable,and 7 cases were invalid,with a total effective rate of 76.67%.In the safety evaluation,there were no obvious adverse reactions.[Conclusions]The Kunkui Kidney Preserving Past has significant clinical efficacy and safety in treating DKD patients with damp-heat stasis syndrome in the clinical proteinuria period.It has significant advantages in reducing urinary protein and protecting renal function,which is worthy of clinical promotion.

Variety Selection and Green Cultivation Technology of Courtyard Ornamental and Edible Peppers

In order to comply with the development trend of the multifunctional use of peppers,we conducted an investigation into the characteristics and features of varieties,potting management techniques,and the methods of extending the fruit ornamental period and other aspects of courtyard ornamental and edible peppers.A set of cultivation techniques suitable for courtyard ornamental and edible peppers has been developed,including timely sowing and seedling,nutrient soil preparation,water and fertilizer management,trimming and pruning,preservation of flowers and fruits,green prevention and control of diseases and pests,harvesting,and so on.

Evaluation of The Effectiveness of Abdominal and Vaginal B-Ultrasound in The Diagnosis of Acute Abdomen in Obstetrics and Gynecology

Objective: To explore the clinical effect of the combined application of abdominal and vaginal B-ultrasound in the diagnosis of acute abdomen in obstetrics and gynecology. Methods: Eighty patients admitted to our hospital from March 2023 to March 2024 were selected, all of whom were acute abdomen patients admitted to the Department of Obstetrics and Gynecology. In this study, the patients were divided into two groups. One group of 40 patients was given a simple abdominal B-ultrasound diagnosis (control group). The other group of 40 patients was given both abdominal and vaginal B-ultrasound examinations (experimental group). The diagnostic accuracy between the two groups was compared. Results: Patients in the experimental group had higher consistency rates with pathological diagnosis results in ectopic pregnancy rupture, embryonic arrest, acute pelvic inflammation, corpus luteum rupture, and intrauterine adhesions as compared to the control group. At the same time, the inspection accuracy rate of the experimental group (92.50%) was higher than that of the control group (70.00%) (P < 0.05). Conclusion: The combined application of abdominal and vaginal B-ultrasound in the diagnosis of acute abdomen was of great significance in improving the accuracy of clinical diagnosis and guiding doctors to provide effective treatment.

Analysis of the Efficacy of Prenatal B-Ultrasound in Diagnosing Fetal Abnormalities

Objective:To explore the positive significance of using prenatal B-ultrasound in diagnosing fetal abnormalities.Methods:A total of 200 pregnant women who visited Shaanxi Provincial People’s Hospital between January 2023 and January 2024 were recruited as the research subjects.All pregnant women received prenatal examinations.A retrospective analysis was carried out to analyze the positive significance of prenatal B-ultrasound examination in the diagnosis of fetal abnormalities.Results:Prenatal B-ultrasound examination detected 10 cases of fetal abnormalities,with a detection rate of 5.00%.When compared with the postnatal examination results of 5.50%,the difference was insignificant(P>0.05).Moreover,comparing the fetal limb abnormalities and cardiovascular abnormalities in prenatal B-ultrasound examination and postnatal examination,one case of congenital heart disease was missed in the prenatal B-ultrasound examination,and the others were consistent with the postnatal examination results,with a coincidence rate of 90.91%,indicating a high compliance rate.Conclusion:Fetal abnormalities have a great impact on mothers,babies,and families,and it is particularly important to strengthen diagnosis during this process.Prenatal B-ultrasound examination can improve the accuracy of diagnosis of fetal abnormalities and can be promoted in clinical practice as a basis for screening fetal abnormalities.

Application of Automated Guided Vehicles in Smart Automated Warehouse Systems:A Survey

Automated Guided Vehicles(AGVs)have been introduced into various applications,such as automated warehouse systems,flexible manufacturing systems,and container terminal systems.However,few publications have outlined problems in need of attention in AGV applications comprehensively.In this paper,several key issues and essential models are presented.First,the advantages and disadvantages of centralized and decentralized AGVs systems were compared;second,warehouse layout and operation optimization were introduced,including some omitted areas,such as AGVs fleet size and electrical energy management;third,AGVs scheduling algorithms in chessboardlike environments were analyzed;fourth,the classical route-planning algorithms for single AGV and multiple AGVs were presented,and some Artificial Intelligence(AI)-based decision-making algorithms were reviewed.Furthermore,a novel idea for accelerating route planning by combining Reinforcement Learning(RL)andDijkstra’s algorithm was presented,and a novel idea of the multi-AGV route-planning method of combining dynamic programming and Monte-Carlo tree search was proposed to reduce the energy cost of systems.

Xiaojianzhong decoction prevents gastric precancerous lesions in rats by inhibiting autophagy and glycolysis in gastric mucosal cells

BACKGROUND Gastric precancerous lesions(GPL)precede the development of gastric cancer(GC).They are characterized by gastric mucosal intestinal metaplasia and dysplasia caused by various factors such as inflammation,bacterial infection,and injury.Abnormalities in autophagy and glycolysis affect GPL progression,and their effective regulation can aid in GPL treatment and GC prevention.Xiaojianzhong decoction(XJZ)is a classic compound for the treatment of digestive system diseases in ancient China which can inhibit the progression of GPL.However,its specific mechanism of action is still unclear.AIM To investigate the therapeutic effects of XJZ decoction on a rat GPL model and the mechanisms underlying its effects on autophagy and glycolysis regulation in GPLs.METHODS Wistar rats were randomly divided into six groups of five rats each and all groups except the control group were subjected to GPL model construction for 18 wk.The rats’body weight was monitored every 2 wk starting from the beginning of modeling.Gastric histopathology was examined using hematoxylin-eosin staining and Alcian blue-periodic acid-Schiff staining.Autophagy was observed using transmission electron microscopy.The expressions of autophagy,hypoxia,and glycolysis related proteins in gastric mucosa were detected using immunohistochemistry and immunofluorescence.The expressions of the following proteins in gastric tissues:B cell lymphoma/Leukemia-2 and adenovirus E1B19000 interacting protein 3(Bnip-3),microtubule associated protein 1 light chain 3(LC-3),moesin-like BCL2-interacting protein 1(Beclin-1),phosphatidylinositol 3-kimase(PI3K),protein kinase B(AKT),mammalian target of rapamycin(mTOR),p53,AMP-activated protein kinase(AMPK),and Unc-51 like kinase 1(ULK1)were detected using western blot.The relative expressions of autophagy,hypoxia,and glycolysis related mRNA in gastric tissues was detected using reverse transcription-polymerase chain reaction.RESULTS Treatment with XJZ increased the rats’body weight and improved GPL-related histopathological manifestations.It also decreased autophagosome and autolysosome formation in gastric tissues and reduced Bnip-3,Beclin-1,and LC-3II expressions,resulting in inhibition of autophagy.Moreover,XJZ down-regulated glycolysis-related monocarboxylate transporter(MCT1),MCT4,and CD147 expressions.XJZ prevented the increase of autophagy level by decreasing gastric mucosal hypoxia,activating the PI3K/AKT/mTOR pathway,inhibiting the p53/AMPK pathway activation and ULK1 Ser-317 and Ser-555 phosphorylation.In addition,XJZ improved abnormal gastric mucosal glucose metabolism by ameliorating gastric mucosal hypoxia and inhibiting ULK1 expression.CONCLUSION This study demonstrates that XJZ may inhibit autophagy and glycolysis in GPL gastric mucosal cells by improving gastric mucosal hypoxia and regulating PI3K/AKT/mTOR and p53/AMPK/ULK1 signaling pathways,providing a feasible strategy for the GPL treatment.

Hydrogen-induced optical properties of FC/Pd/Mg films:Roles of grain size and grain boundary

Nanomodification is an effective method to solve the thermodynamic and kinetics limitation of Magnesium(Mg)-based materials,which shows promising application prospects in hydrogen energy field.However,the role of the grain size of pure Mg on the hydrogen-induced performance of the hydrogen sensitive thin film under cyclic hydrogen loading/unloading process at room temperature has rarely been studied systematically.To study the relationship between the structure of Mg layer and the hydrogen-induced optical performance of fluorocarbon(FC)/Pd/Mg films,a series of Mg with different internal structures were prepared by changing the velocity of sputtered atoms under different sputtering powers.The FC/Pd/Mg(40 W)film with fine nanostructure showed faster hydrogenation/dehydrogenation kinetics as well as a larger optical conversion range,which can be attributed to the large population of grain boundaries with high grain boundary energy and more hydrogen diffusion path.As sputtering power gradually increased from 40 W to 300 W,the grain inside films grew larger.The FC/Pd/Mg(300 W)film had more columnar-like regions inside and less grain boundaries with lower energy contributing to slower hydrogen absorption/desorption kinetics and lower optical conversion range.

ELABELA protects against diabetic kidney disease by activating high glucose-inhibited renal tubular autophagy

ELABELA(ELA),an endogenous ligand of the apelin receptor(also known as apelin peptide jejunum[APJ]),has been shown to decrease in the plasma of patients with diabetic kidney disease(DKD).In the current study,we explored the potential function as well as the underlying mechanisms of ELA in DKD.We first found that the ELA levels were decreased in the kidneys of DKD mice.Then,we found that ELA administration mitigated renal damage and downregulated the expression of fibronectin,collagenⅣ,and transforming growth factor-β1 in the db/db mice and the high glucose cultured HK-2 cells.Furthermore,the autophagy markers,Beclin-1 and LC3-Ⅱ/LC3-Ⅰratio,were significantly impaired in DKD,but the ELA treatment reversed these alterations.Mechanistically,the inhibitory effects of ELA on the secretion of fibrosis-associated proteins in high glucose conditions were blocked by pretreatment with 3-methyladenine(an autophagy inhibitor).In summary,these in vivo and in vitro results demonstrate that ELA effectively protects against DKD by activating high glucose-inhibited renal tubular autophagy,potentially serving as a novel therapeutic candidate for DKD.

Treatment of periprosthetic knee infection and coexistent periprosthetic fracture:A case report and literature review

BACKGROUND Periprosthetic joint infection(PJI) and periprosthetic fracture(PPF) are among the most serious complications following total knee arthroplasty. Herein, we present one patient with these two complications with details on the characteristics, treatment strategy, and outcome.CASE SUMMARY A 69-year-old female patient who suffered from PJI and PPF following total knee arthroplasty was treated by a two-stage revision surgery. After thorough foreign material removal and debridement, we used a plate that was covered with antibiotic-loaded bone cement to link with a hand-made cement spacer to occupy the joint space and fix the fracture. Although the infection was cured, the fracture did not heal and caused bone defect due to the long interval between debridement and revision. In the revision surgery, a cemented stem and cortical allogenic splints were used to reconstruct the fracture and bone defect. At the final followup 27 mo after revision, the patient was satisfied with postoperative knee functions with satisfactory range of motion(104°) and Hospital for Special Surgery knee score(82 points). The radiographs showed no loosening of the prosthesis and that the bone grafts healed well with the femur.CONCLUSION Our two-stage revision surgery has proved to be successful and may be considered in other patients with PJI and PPF.

全覆膜金属支架在无法行外科手术的胰腺导管内乳头状黏液性肿瘤患者中的应用

目的探讨全覆膜金属支架在治疗无法行外科手术的胰腺导管内乳头状黏液性肿瘤(IPMN)患者中的应用价值。方法回顾性分析2015年12月-2020年6月在江苏省苏北人民医院内镜诊治中心行内镜逆行胰胆管造影术(ERCP),在胰管留置全覆膜金属支架的9例IPMN患者的临床资料。结果9例患者均行ERCP,术中见乳头呈鱼嘴样开口,插管后均可见胶冻状液体流出,造影见主胰管局部或弥漫扩张,分枝胰管呈囊状扩张,5例置入10 mm×80 mm、4例置入10 mm×60 mm全覆膜金属支架,2例术中同时置入胆道支架。术后患者腹痛和恶心呕吐等症状明显缓解,2例术后出现高淀粉酶血症,给予对症治疗后缓解,无胰腺炎、胆管炎、出血和穿孔等并发症发生。术后随访12~24个月,无腹痛和复发,无支架移位,合并糖尿病患者血糖控制稳定,无新发糖尿病,1例随访至16个月时,支架堵塞,行胰管清理及支架更换。出院当天生活质量卡氏评分为(96.67±3.54)分,较术前的(82.78±3.63)分明显提高,两者比较,差异有统计学意义(P<0.05),术后3和6个月生活质量卡氏评分为(94.82±3.87)和(91.33±2.50)分,与出院当天比较,差异无统计学意义(P>0.05)。结论对于无法行外科手术的IPMN患者,内镜下胰管全覆膜金属支架置入术安全有效,能有效延缓疾病进展,减少胰腺炎复发和手术频次,提高患者生活质量,值得临床进一步推广。

激光选区熔化增材制造高强度Mg−15Gd−1Zn−0.4Zr合金的显微组织与力学性能

为了验证激光选区熔化(SLM)成型技术制造高性能镁−稀土合金的可行性,研究SLM工艺对Mg-15Gd-1Zn-0.4Zr(质量分数,%)(GZ151K)镁合金显微组织与力学性能的影响。结果表明,打印态(激光选区熔化态)GZ151K镁合金晶粒(约为2μm)和第二相细小、织构较弱;室温下,打印态GZ151K镁合金的屈服强度为345 MPa,抗拉强度为368 MPa,伸长率为3.0%。200℃、64 h时效处理(T5)后,合金的屈服强度增加至410 MPa、抗拉强度增加至428 MPa、伸长率增加至3.4%,拉伸性能均高于传统的重力金属型铸造GZ151K-T6合金,其中,屈服强度增幅高达122 MPa。打印态GZ151K镁合金的主要强化机制为细晶、细小第二相和残余应力强化;经T5处理后,析出相进一步提高合金的屈服强度。

Research on the Model of Consumer Health Information Seeking Behavior via Social Media

Purpose: We aim to create a model of consumer health information seeking behavior via social media, then to have a better understand of it. After that further efforts should be made to provide targeted recommendations for media managers to promote health communication via social media. Methods: Our custom model was derived from literature review, empirical research was tested by the use of questionnaire investigation, and then the collected data were analyzed by structural equation model tool SmartPLS. Finally, the custom model was modified according to the experimental results of SmartPLS. Results: A total of 239 (66.39%) of the respondents were female and 121 (33.61%) were male. The maximum of two stages of age were 18 - 29 (70.56%), 30 - 39 (13.89%). Wechat (60.28%), QQ Zone (55.22%), Micro-blog (48.89%) were the most commonly used social media to obtain health information. About 44.72% of respondents used social media to obtain health information multiple times a day. The whole numerical values of AVE, cronbach’s alpha, CR and square roots of AVE were above the benchmarks of themselves and showed great reliability and validity. All the 11 hypotheses had obvious statistical significance, the P-value of eight path coefficients exhibited <0.001, one path coefficient exhibited <0.01 and two path coefficients exhibited <0.05. Conclusions: A suitable model of consumer health information seeking behavior via social media was created and some inner relationships were found. Namely, gratification of health information and its platform had a positive effect on attitudes toward health information seeking behavior. Health information literacy and health status were proved to have a significant influence on attitudes toward health information seeking behavior, subject norms and perceived behavioral control respectively. In addition, attitudes toward the health information seeking behavior, subject norms and perceived behavioral control were proved to positively associate with health information seeking behavior intention.

Investigation of the Relationship among Water and Crop Production under Bounded Irrigation Conditions

Water scarcity is relative and variable concept that can occur at any level of supply and demand. It is also a social construct, which is linked to the intervention in the water cycle and changes over time as a result of natural hydrological change. It is more severe when water acts as a backbone in economic policies, planning and management methods. Water scarcity can be expected to increase with most forms of economic development, but, if properly identified, many of its causes can be expected and avoided or mitigated. However, the limited irrigation management is considered a very important issue in the agricultural scope. Therefore, in this study, the relationship between water, crop production, photosynthesis, crop transpiration, crop growth, crop yields and water use efficiency have been discussed under limited irrigation conditions. However, the crops have some ability to adapt and resist against limited irrigation. Hence, under high temperate conditions, this is a shortage of water and photosynthesis is decreased with a pore (stoma) restraining. At the same time, the evapotranspiration reaches to the utmost value and the water use efficiency rises because of optimal monitoring of leaf pore (stoma). Therefore, the modality which is the reduction of the risks and improving industrial control in incomplete irrigation are the chief constraints of providing irrigation water in the future, which leads to increased crop production and ultimately providing a provision of food security.

经内镜腔内射频消融联合胆管支架置入治疗晚期胰腺癌并梗阻性黄疸的临床研究

目的探讨经内镜腔内射频消融(RFA)联合胆管支架置入治疗晚期胰腺癌并梗阻性黄疸的安全性和疗效。方法回顾性分析46例失去手术机会的晚期胰腺癌合并梗阻性黄疸患者的临床资料,比较射频组(n=16,腔内RFA联合支架置入)和对照组(n=30,单纯支架置入)术后并发症发生情况、黄疸消退程度、腹痛缓解情况、支架中位通畅时间和中位生存时间。结果两组患者术后均未出现穿孔、出血、胆漏和胰漏等严重并发症,术后胆管炎和一过性胰腺炎发生率比较,差异均无统计学意义(P>0.05)。术后1周射频组血清总胆红素(TBIL)和直接胆红素(DBIL)分别为(62.99±42.31)和(50.89±37.78)μmol/L,较术前的(181.51±114.14)和(156.90±105.79)μmol/L明显降低,对照组分别为(112.21±84.27)和(84.23±70.01)μmol/L,较术前的(184.06±130.00)和(160.65±119.93)μmol/L明显降低,射频组黄疸消退程度较对照组更明显(P<0.05)。两组患者术后1个月视觉模拟评分(VAS)均较术前降低,射频组腹痛缓解有效率为87.5%,明显高于对照组的26.7%(P<0.05)。射频组患者中位生存时间和支架中位通畅时间分别为296和241 d,均长于对照组的240和188 d(P<0.05)。结论对于晚期胰腺癌合并梗阻性黄疸的患者,腔内RFA联合胆管支架较单纯胆管支架置入能够更有效地减黄、缓解癌性疼痛、延长支架通畅期、延长患者生存时间、提高患者生活质量,疗效确切,值得临床进一步推广应用。

内镜逆行胰胆管造影术应用于胆总管结石合并尿毒症患者的临床分析

目的评价内镜逆行胰胆管造影术(ERCP)应用于胆总管结石合并尿毒症患者的有效性及安全性。方法回顾性分析2015年6月-2020年12月17例在苏北人民医院行ERCP治疗的胆总管结石合并尿毒症患者的病例特点、治疗效果及并发症发生情况。结果17例患者共行19次ERCP,平均1.1次/例,治疗成功率为94.1%(16/17)。术后总体并发症发生率为29.4%(5/17),其中胰腺炎2例(11.8%)、迟发性出血1例(5.9%)和胆道感染2例(11.8%),均经治疗后康复。结论胆总管结石合并尿毒症患者行ERCP是安全、有效的,但需做好术后并发症的防治措施,以进一步提高ERCP诊治的安全性。