By binding to multiple antigens simultaneously,multispecific antibodies are expected to substantially improve both the activity and long-term efficacy of antibody-based immunotherapy.Immune cell engagers,a subclass of...By binding to multiple antigens simultaneously,multispecific antibodies are expected to substantially improve both the activity and long-term efficacy of antibody-based immunotherapy.Immune cell engagers,a subclass of antibody-based constructs,consist of engineered structures designed to bridge immune effector cells to their target,thereby redirecting the immune response toward the tumor cells or infected cells.The increasing number of recent clinical trials evaluating immune cell engagers reflects the important role of these molecules in new therapeutic approaches for cancer and infections.In this review,we discuss how different immune cell types(T and natural killer lymphocytes,as well as myeloid cells)can be bound by immune cell engagers in immunotherapy for cancer and infectious diseases.Furthermore,we explore the preclinical and clinical advancements of these constructs,and we discuss the challenges in translating the current knowledge from cancer to the virology field.Finally,we speculate on the promising future directions that immune cell engagers may take in cancer treatment and antiviral therapy.展开更多
The recently published landmark paper by Bergaggio et al.from Roberto Chiarle’s group in Cancer Cell1 investigates an elegant double-hit strategy to improve anti-cancer immunotherapy.This important approach demonstra...The recently published landmark paper by Bergaggio et al.from Roberto Chiarle’s group in Cancer Cell1 investigates an elegant double-hit strategy to improve anti-cancer immunotherapy.This important approach demonstrates in a preclinical model that chimeric antigen receptor(CAR)-T cell treatment can be rendered more efficient by increasing the cell surface expression of the CAR target structure via a small molecule.展开更多
The first scientists to coin the term“trained immunity”were Mihai G.Netea,Jessica Quintin,and Jos W.M.van der Meer in a‘Perspective’article in 2011[2].With the publication of vast amounts of experimental data and ...The first scientists to coin the term“trained immunity”were Mihai G.Netea,Jessica Quintin,and Jos W.M.van der Meer in a‘Perspective’article in 2011[2].With the publication of vast amounts of experimental data and follow-up reviews,the concept that the innate immune system can develop a memory function in parallel to the well-recognized adaptive memory,mediated by B and T lymphocytes,is largely accepted.展开更多
基金CR is supported by a grant from the National Research Fund Luxembourg(FNR),Doctoral Training Unit"i2TRON",PRIDE19/14254520,project 20200831.
文摘By binding to multiple antigens simultaneously,multispecific antibodies are expected to substantially improve both the activity and long-term efficacy of antibody-based immunotherapy.Immune cell engagers,a subclass of antibody-based constructs,consist of engineered structures designed to bridge immune effector cells to their target,thereby redirecting the immune response toward the tumor cells or infected cells.The increasing number of recent clinical trials evaluating immune cell engagers reflects the important role of these molecules in new therapeutic approaches for cancer and infections.In this review,we discuss how different immune cell types(T and natural killer lymphocytes,as well as myeloid cells)can be bound by immune cell engagers in immunotherapy for cancer and infectious diseases.Furthermore,we explore the preclinical and clinical advancements of these constructs,and we discuss the challenges in translating the current knowledge from cancer to the virology field.Finally,we speculate on the promising future directions that immune cell engagers may take in cancer treatment and antiviral therapy.
基金C.R.is funded through the Fonds National de la Recherche Luxembourg,Doctoral Training Unit i2TRON,PRIDE19/14254520,project 20200831。
文摘The recently published landmark paper by Bergaggio et al.from Roberto Chiarle’s group in Cancer Cell1 investigates an elegant double-hit strategy to improve anti-cancer immunotherapy.This important approach demonstrates in a preclinical model that chimeric antigen receptor(CAR)-T cell treatment can be rendered more efficient by increasing the cell surface expression of the CAR target structure via a small molecule.
文摘The first scientists to coin the term“trained immunity”were Mihai G.Netea,Jessica Quintin,and Jos W.M.van der Meer in a‘Perspective’article in 2011[2].With the publication of vast amounts of experimental data and follow-up reviews,the concept that the innate immune system can develop a memory function in parallel to the well-recognized adaptive memory,mediated by B and T lymphocytes,is largely accepted.
