Schwannoma is a common peripheral neural neoplasm that could present as a primary skin lesion. In addition to typical schwannoma with classic Antoni A and Antoni B areas, many variant types have been described, such a...Schwannoma is a common peripheral neural neoplasm that could present as a primary skin lesion. In addition to typical schwannoma with classic Antoni A and Antoni B areas, many variant types have been described, such as plexiform, cellular, epithelioid, and ancient schwannomas. Glandular schwannoma is a rare variant characterized by the presence of glands in an otherwise typical schwannoma. There are also a few reported cases in the literature of pseudoglandular schwannoma f rom central nervous system, eye, submandible, and shoulder, in which the gland- like structures were lined by Schwann cells. We report here a patient with a ben ign cutaneous schwannoma composed of predominantly gland-like spaces that conta ined mucinous material and were lined by Schwann cells confirmed by immunohistoc hemistry and ultrastructural studies. The tumor was well circumscribed and showe d minimal cytologic atypia, indicating benignity. We report this unusual case of benign cutaneous pseudoglandular schwannoma to further awareness of the morphol ogic diversity of schwannoma.展开更多
文摘Schwannoma is a common peripheral neural neoplasm that could present as a primary skin lesion. In addition to typical schwannoma with classic Antoni A and Antoni B areas, many variant types have been described, such as plexiform, cellular, epithelioid, and ancient schwannomas. Glandular schwannoma is a rare variant characterized by the presence of glands in an otherwise typical schwannoma. There are also a few reported cases in the literature of pseudoglandular schwannoma f rom central nervous system, eye, submandible, and shoulder, in which the gland- like structures were lined by Schwann cells. We report here a patient with a ben ign cutaneous schwannoma composed of predominantly gland-like spaces that conta ined mucinous material and were lined by Schwann cells confirmed by immunohistoc hemistry and ultrastructural studies. The tumor was well circumscribed and showe d minimal cytologic atypia, indicating benignity. We report this unusual case of benign cutaneous pseudoglandular schwannoma to further awareness of the morphol ogic diversity of schwannoma.
