Ulcerative colitis and Crohn’s disease(CD)are characterized by inflammation of the intestinal mucosa and symptoms of abdominal pain and diarrhea.Many studies have shown an association between elevated levels of prost...Ulcerative colitis and Crohn’s disease(CD)are characterized by inflammation of the intestinal mucosa and symptoms of abdominal pain and diarrhea.Many studies have shown an association between elevated levels of prostaglandins and mucosal damage in inflammatory bowel disease.We report a 50-year-old woman with a history of CD and open-angle glaucoma.Her glaucoma was treated with latanoprost,a prostaglandin analog,which was associated with an exacerbation of her CD.On discontinuation of latanoprost,her CD symptoms disappeared completely.This case suggests that in a patient with CD,topical administration of latanoprost may result in sufficient systemic absorption and circulation to promote a relapse of CD.This finding has important implications,not only for patients with inflammatory bowel disease and glaucoma,but also for both ophthalmologists and gastroenterologists.展开更多
基金supported by the 2013–2014 Bristol-Myers Squibb Virology Fellows Research Training Program.The manuscript received no direct financial support.
文摘Ulcerative colitis and Crohn’s disease(CD)are characterized by inflammation of the intestinal mucosa and symptoms of abdominal pain and diarrhea.Many studies have shown an association between elevated levels of prostaglandins and mucosal damage in inflammatory bowel disease.We report a 50-year-old woman with a history of CD and open-angle glaucoma.Her glaucoma was treated with latanoprost,a prostaglandin analog,which was associated with an exacerbation of her CD.On discontinuation of latanoprost,her CD symptoms disappeared completely.This case suggests that in a patient with CD,topical administration of latanoprost may result in sufficient systemic absorption and circulation to promote a relapse of CD.This finding has important implications,not only for patients with inflammatory bowel disease and glaucoma,but also for both ophthalmologists and gastroenterologists.
