Calcium-independent phospholipase A<sub>2</sub> (iPLA<sub>2</sub>) belongs to the group VI family of phospholipase superfamily (PLA<sub>2</sub>) that catalyses the hydrolysis of gly...Calcium-independent phospholipase A<sub>2</sub> (iPLA<sub>2</sub>) belongs to the group VI family of phospholipase superfamily (PLA<sub>2</sub>) that catalyses the hydrolysis of glycerophospholipids at the sn-2 ester bond, producing unesterified fatty acids and 2-lysophospholipids. Research interests on iPLA<sub>2</sub> have not been as significant as those on secretary PLA<sub>2</sub> and cytosolic PLA<sub>2</sub>. However, more efforts have been made recently on understanding the expression, regulation and biological function of iPLA<sub>2</sub>. iPLA<sub>2</sub> plays important roles in several biological processes, including signal transduction, phospholipid remodelling, eicosanoid formation, cell proliferation, cell differentiation and apoptosis. Modulation of iPLA<sub>2</sub> activity can have prominent effects on cellular metabolism, central nervous system and cardiovascular functions. Thus, dysregulation iPLA<sub>2</sub> can play a vital role in the pathogenesis of several diseases. The aim of this review is to provide the current understanding of the structure, function and regulation of group VI iPLA<sub>2</sub> and highlight its potential mechanisms of action in mediating several neurological disorders and cancer.展开更多
文摘Calcium-independent phospholipase A<sub>2</sub> (iPLA<sub>2</sub>) belongs to the group VI family of phospholipase superfamily (PLA<sub>2</sub>) that catalyses the hydrolysis of glycerophospholipids at the sn-2 ester bond, producing unesterified fatty acids and 2-lysophospholipids. Research interests on iPLA<sub>2</sub> have not been as significant as those on secretary PLA<sub>2</sub> and cytosolic PLA<sub>2</sub>. However, more efforts have been made recently on understanding the expression, regulation and biological function of iPLA<sub>2</sub>. iPLA<sub>2</sub> plays important roles in several biological processes, including signal transduction, phospholipid remodelling, eicosanoid formation, cell proliferation, cell differentiation and apoptosis. Modulation of iPLA<sub>2</sub> activity can have prominent effects on cellular metabolism, central nervous system and cardiovascular functions. Thus, dysregulation iPLA<sub>2</sub> can play a vital role in the pathogenesis of several diseases. The aim of this review is to provide the current understanding of the structure, function and regulation of group VI iPLA<sub>2</sub> and highlight its potential mechanisms of action in mediating several neurological disorders and cancer.
