Objective:In the present study, the protein structure model of human amylin was generated to understand the protein's structure, function and mechanism of the action. Methods: The stereo chemical quality of the pr...Objective:In the present study, the protein structure model of human amylin was generated to understand the protein's structure, function and mechanism of the action. Methods: The stereo chemical quality of the protein model was checked by usingin silico analysis withSWISSMODEL,SOPMA,PROCHECK, ProSA andQMEAN servers. Results:The 66.7% residues in the core region of Ramachandran plot showing high accuracy of protein model and the QMEAN Z score of –6.57 indicates the overall model quality of amylin protein. Conclusions: These results may be helpful for further investigation on developing target molecules for amylin proteins that play a key role in type 2 diabetes.展开更多
文摘Objective:In the present study, the protein structure model of human amylin was generated to understand the protein's structure, function and mechanism of the action. Methods: The stereo chemical quality of the protein model was checked by usingin silico analysis withSWISSMODEL,SOPMA,PROCHECK, ProSA andQMEAN servers. Results:The 66.7% residues in the core region of Ramachandran plot showing high accuracy of protein model and the QMEAN Z score of –6.57 indicates the overall model quality of amylin protein. Conclusions: These results may be helpful for further investigation on developing target molecules for amylin proteins that play a key role in type 2 diabetes.
