Poly(lactic-co-glycolic acid)(PLGA)microparticles represent an important class of materials used for drug delivery.Current synthesis frequently uses conventional emulsion,where dichloromethane(DCM)is used as the organ...Poly(lactic-co-glycolic acid)(PLGA)microparticles represent an important class of materials used for drug delivery.Current synthesis frequently uses conventional emulsion,where dichloromethane(DCM)is used as the organic phase solvent.Due to the health and environmental toxicity of DCM and its slow degradation,this work replaces DCM with a greener solvent,dimethyl carbonate(DMC).展开更多
基金This work was supported by the DOD(CDMRP Award PR171305)and UC Davis.
文摘Poly(lactic-co-glycolic acid)(PLGA)microparticles represent an important class of materials used for drug delivery.Current synthesis frequently uses conventional emulsion,where dichloromethane(DCM)is used as the organic phase solvent.Due to the health and environmental toxicity of DCM and its slow degradation,this work replaces DCM with a greener solvent,dimethyl carbonate(DMC).
