The mouse double minute 4(MDM4)is emerging from the shadow of its more famous relative MDM2 and is starting to steal the limelight,largely due to its therapeutic possibilities.MDM4 is a vital regulator of the tumor su...The mouse double minute 4(MDM4)is emerging from the shadow of its more famous relative MDM2 and is starting to steal the limelight,largely due to its therapeutic possibilities.MDM4 is a vital regulator of the tumor suppressor p53?It restricts p53 transcriptional activity and also,at least in development,facilitates MDM2's E3 ligase activity toward p53.These functions of MDM4 are critical for normal cell function and a proper response to stress.Their importance for proper cell maintenance and proliferation identifies them as a risk for deregulation associated with the uncontrolled growth of cancer.MDM4 tails are vital for its function,where its N-terminus transactivation domain engages p53 and its C-terminus RING domain binds to MDM2.In this review,we highlight recently identified cellular functions of MDM4 and survey emerging therapies directed to correcting its dys regulation in disease.展开更多
In this article (p.240, MDM4 Inhibition section, second paragraph), the drug name of Aileron stapled peptide ‘ALN-6924’ was incorrectly cited (as ‘ALN-6942’). This mistake was due to human error. The conclusions o...In this article (p.240, MDM4 Inhibition section, second paragraph), the drug name of Aileron stapled peptide ‘ALN-6924’ was incorrectly cited (as ‘ALN-6942’). This mistake was due to human error. The conclusions of the review are not affected and the authors apologize for this error.展开更多
文摘The mouse double minute 4(MDM4)is emerging from the shadow of its more famous relative MDM2 and is starting to steal the limelight,largely due to its therapeutic possibilities.MDM4 is a vital regulator of the tumor suppressor p53?It restricts p53 transcriptional activity and also,at least in development,facilitates MDM2's E3 ligase activity toward p53.These functions of MDM4 are critical for normal cell function and a proper response to stress.Their importance for proper cell maintenance and proliferation identifies them as a risk for deregulation associated with the uncontrolled growth of cancer.MDM4 tails are vital for its function,where its N-terminus transactivation domain engages p53 and its C-terminus RING domain binds to MDM2.In this review,we highlight recently identified cellular functions of MDM4 and survey emerging therapies directed to correcting its dys regulation in disease.
文摘In this article (p.240, MDM4 Inhibition section, second paragraph), the drug name of Aileron stapled peptide ‘ALN-6924’ was incorrectly cited (as ‘ALN-6942’). This mistake was due to human error. The conclusions of the review are not affected and the authors apologize for this error.
