Osteosarcoma is an aggressive malignant bone sarcoma common among children,adolescents,and young adults.Approximately 20%of patients present with pulmonary metastasis,and an additional 40%develop pulmonary osteosarcom...Osteosarcoma is an aggressive malignant bone sarcoma common among children,adolescents,and young adults.Approximately 20%of patients present with pulmonary metastasis,and an additional 40%develop pulmonary osteosarcoma later.The survival outcome in patients with recurrent osteosarcoma and pulmonary osteosarcoma has not improved overmany decades[1].展开更多
基金supported by the National Cancer Institute(R03CA273468,R03CA259901,P30CA043703,T32GM007250,T32CA059366,and K12CA076917)St.Baldrick’s Foundation,Hyundai Hope-on-Wheels Scholar Hope Grant,Andrew McDonough B+Foundation,Curing Kids Cancer,MIB Agents,Sarcoma Foundation of America,Sam Day Foundation,Children’s Cancer Research Fund,Center for Pediatric Immunotherapy at Rainbow,and a sponsored research agreement from MedPacto,Inc.who provided vactosertib for both in vitro and in vivo experiments.
文摘Osteosarcoma is an aggressive malignant bone sarcoma common among children,adolescents,and young adults.Approximately 20%of patients present with pulmonary metastasis,and an additional 40%develop pulmonary osteosarcoma later.The survival outcome in patients with recurrent osteosarcoma and pulmonary osteosarcoma has not improved overmany decades[1].
