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Determinants of invasive strategy in elderly patients with non-ST elevation myocardial infarction 被引量:1
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作者 Antonin Negers Jacques Boddaert +5 位作者 Lucie Mora Jean-Louis Golmard Laura Moisi Ariel Cohen jean-philippe collet Alice Breining 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2017年第7期465-472,共8页
Background Knowledge gaps across literature prevent current guidelines from providing the profile of elderly patients most likely to derive benefit fi^om invasive strategy (IS) in non ST-elevation myocardial infarct... Background Knowledge gaps across literature prevent current guidelines from providing the profile of elderly patients most likely to derive benefit fi^om invasive strategy (IS) in non ST-elevation myocardial infarction (NSTEMI). Furthermore, the benefit of IS in a real-world elderly population with NSTEMI remains unclear. The aims of this study were to determine factors that lead the cardiologist to opt for an IS in elderly patients with NSTEMI, and to assess the impact of IS on the 6-month all-cause mortality. Methods This multicenter prospective study enrolled all consecutive patients aged 〉 75 years old who presented a NSTEMI and were hospitalized in cardiology intensive care unit between February 2014 and February 2015. Patients were compared on the basis of reperfusion strategy (invasive or conservative) and living status at six months, in order to determine multivariate predictors of the realization of an IS and multivariate predictors of 6-month mor- tality. Results A total of 141 patients were included; 87 (62%) underwent an IS. The strongest independent determinants of IS were younger age [odds ratio (OR): 0.85, 95%-confidence interval (CI): 0.78-0.92; P 〈 0.001) and lower "Cumulative Illness Rating Scale-Geriatric" number of categories score (OR: 0.83, 95%CI: 0.73-0.95; P = 0.002). IS was not significantly associated with 6-month survival (OR: 0.80, 95%CI: 0.27-2.38; P = 0.69). Conclusions In real-world elderly patients with NSTEMI, younger patients with fewer comorbidities profited more often from an IS. However, IS did not modify 6-month all-cause mortality. 展开更多
关键词 COMORBIDITY Coronary angiography Decision making MORTALITY Myocardial infarction
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非ST段抬高急性冠脉综合征患者噻吩并吡啶类药物预治疗的再评价:一项系统性综述和meta分析
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作者 Anne BeUemain-Appaix Mathieu Kerneis +10 位作者 Stephen A O'Connor Johanne Silvain Michel Cucherat Farzin Beygui Olivier Barthelemy jean-philippe collet Laurent Jacq Francois Bernasconi Gilles Montalescot 葛兴 史旭波 《英国医学杂志中文版》 2015年第3期129-129,共1页
目的探讨非sT段抬高急性冠脉综合征患者应用P2Y12受体拮抗剂预治疗与未行预治疗相比的有效性和安全性。数据来源两名研究者独立检索Medline、Embase、Cochrane Controlled Trials和BioMed Central数据库,查找2001年至2014年随机对照试... 目的探讨非sT段抬高急性冠脉综合征患者应用P2Y12受体拮抗剂预治疗与未行预治疗相比的有效性和安全性。数据来源两名研究者独立检索Medline、Embase、Cochrane Controlled Trials和BioMed Central数据库,查找2001年至2014年随机对照试验和观察性研究。入选标准研究必须报告全因病死率(主要疗效终点)和大出血事件(安全性终点)结局。数据提取独立提取和分析有关样本量、人群特征、药物剂量、服药延迟情况和临床预后信息的数据。 展开更多
关键词 急性冠脉综合征 预处理 系统 吡啶 噻吩 ST 患者 评估
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