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星形胶质细胞中连接蛋白43在肌萎缩侧索硬化中促发运动神经元毒性 被引量:1
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作者 Akshata A.Almad Arpitha Doreswamy +5 位作者 Sarah K.Gross jean-philippe richard Yuqing Huo Norman Haughey Nicholas J.Maragakis 王晶 《神经损伤与功能重建》 2016年第4期F0003-F0003,共1页
肌萎缩侧索硬化(ALS)是一种神经退行性疾病,其特征是中枢神经系统中运动神经元的进行性丧失。星形胶质细胞在ALS的疾病进程中起重要作用。星形胶质细胞通过缝隙连接蛋白家族,如连接蛋白(Connexin,Cx)互相连接。Cx43是中枢神经系统中保... 肌萎缩侧索硬化(ALS)是一种神经退行性疾病,其特征是中枢神经系统中运动神经元的进行性丧失。星形胶质细胞在ALS的疾病进程中起重要作用。星形胶质细胞通过缝隙连接蛋白家族,如连接蛋白(Connexin,Cx)互相连接。Cx43是中枢神经系统中保持稳态的主要星形胶质细胞连接蛋白。在病理状态下,连接蛋白的表达和功能发生改变。本文发现,在ALS中Cx43异常增高是星形胶质细胞介导的毒性作用机制之一。笔者观察到,在ALS SOD1^(G93A)小鼠模型的疾病进程中,Cx43表达进行性增高。尤其是,在ALS患者的运动皮质和脊髓也能检测到Cx43增高。从SOD1^(G93A)小鼠中分离的星形胶质细胞,与人诱导多能干细胞衍生的星形胶质细胞一样,都检测到Cx43蛋白增高,且为独立于神经元共培养的内源性现象。与对照的星形胶质细胞过表达的野生型SOD1(SOD1^(WT))相比,SOD1^(G93A)星形胶质细胞中增高的Cx43表达可产生重要的功能性影响。本文发现,SOD1^(G93A)星形胶质细胞表现出缝隙连接偶联增强,半通道介导活动升高,细胞内钙离子水平上升。最后,本文检测Cx43蛋白表达升高对MN生存的影响,发现应用pan-Cx43阻滞剂和Cx43半通道阻滞剂均对与SOD1^(G93A)星形胶质细胞共培养的MNs有神经保护作用。这些新发现展示出未被认知的Cx43在ALS相关的运动神经元丢失中所起作用。 展开更多
关键词 星形胶质细胞 连接蛋向 运动神经元 肌萎缩侧索硬化 诱导多能干细胞
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Building an Earth Observations Data Cube: lessons learned from the Swiss Data Cube (SDC) on generating Analysis Ready Data (ARD) 被引量:12
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作者 Gregory Giuliani Bruno Chatenoux +5 位作者 Andrea De Bono Denisa Rodila jean-philippe richard Karin Allenbach Hy Dao Pascal Peduzzi 《Big Earth Data》 EI 2017年第1期100-117,共18页
Pressures on natural resources are increasing and a number of challenges need to be overcome to meet the needs of a growing population in a period of environmental variability.Some of these environmental issues can be... Pressures on natural resources are increasing and a number of challenges need to be overcome to meet the needs of a growing population in a period of environmental variability.Some of these environmental issues can be monitored using remotely sensed Earth Observations(EO)data that are increasingly available from a number of freely and openly accessible repositories.However,the full information potential of EO data has not been yet realized.They remain still underutilized mainly because of their complexity,increasing volume,and the lack of efficient processing capabilities.EO Data Cubes(DC)are a new paradigm aiming to realize the full potential of EO data by lowering the barriers caused by these Big data challenges and providing access to large spatio-temporal data in an analysis ready form.Systematic and regular provision of Analysis Ready Data(ARD)will significantly reduce the burden on EO data users.Nevertheless,ARD are not commonly produced by data providers and therefore getting uniform and consistent ARD remains a challenging task.This paper presents an approach to enable rapid data access and pre-processing to generate ARD using interoperable services chains.The approach has been tested and validated generating Landsat ARD while building the Swiss Data Cube. 展开更多
关键词 Data Cube Earth Observations Landsat automatic processing analysis ready Data
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