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母亲暴露于常规空气污染物与后代的先天性心脏缺陷:来自全国出生缺陷预防研究的结果
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作者 jeanette a.stingone Thomas J.Luben +14 位作者 Julie L.Daniels Montserrat Fuentes David B.Richardson Arthur S.Aylsworth Amy H.Herring Marlene Anderka Lorenzo Botto Adolfo Correa Suzanne M.Gilboa Peter H.Langlois Bridget Mosley Gary M.Shaw Csaba Siffel Andrew F.Olshan National Birth Defects Prevention Study 《环境与职业医学》 CAS 北大核心 2014年第12期929-929,共1页
[背景]流行病学文献表明,空气污染物暴露与胎儿的发育相关联。[目的]探讨产妇在妊娠2-8周期间的空气污染物暴露及其与先天性心脏缺陷的关联。[方法]此项出生缺陷预防研究是一项由9个州参加的病例对照研究。给参加这项研究的妊娠妇女分配... [背景]流行病学文献表明,空气污染物暴露与胎儿的发育相关联。[目的]探讨产妇在妊娠2-8周期间的空气污染物暴露及其与先天性心脏缺陷的关联。[方法]此项出生缺陷预防研究是一项由9个州参加的病例对照研究。给参加这项研究的妊娠妇女分配1周和7周里一氧化碳、二氧化氮、臭氧、二氧化硫的每日最高浓度平均值,以及细颗粒物和粗颗粒物的24 h测量值,采用的方法是在妊娠早期收集这些妇女住所50 km内最接近的空气监测点的测量值。根据不同的污染物,最多4 632例活产对照和3 328例活产、死胎或流产病例有空气污染暴露的数据。应用分层回归模型,并以产妇的人口统计学、烟草和酒精使用情况进行调整。对于多污染物共同暴露的情况,则采用主成分分析来评估这些关联。[结果]二氧化氮暴露与主动脉缩窄及肺动脉瓣狭窄之间存在正性关联。细颗粒物暴露与左室发育不良心脏综合征呈正性相关,但与房间隔缺损呈负性相关。检测个体的暴露周数表明,使用7周的平均水平未观察到污染物与缺陷之间的关联。多污染物分析的结果支持左室流出道阻塞与二氧化氮之间、左室发育不良心脏综合征与颗粒物之间存在关联,尽管在最高的暴露水平时估计值是下降的。[结论]采用每日最高污染物水平探讨个体暴露周数揭示了某些污染物与心脏缺陷之间存在一些正向关联,并且提示在妊娠期间存在潜在的敏感性窗口期。 展开更多
关键词 先天性心脏缺陷 空气污染物 出生缺陷预防 母亲暴露 病例对照研究 心脏综合征 细颗粒物 后代
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The Semantic Data Dictionary-An Approach for Describing and Annotating Data
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作者 Sabbir M.Rashid James P.McCusker +5 位作者 Paulo Pinheiro Marcello P.Bax Henrique O.Santos jeanette a.stingone Amar K.Das Deborah L.McGuinness 《Data Intelligence》 2020年第4期443-486,共44页
It is common practice for data providers to include text descriptions for each column when publishing data sets in the form of data dictionaries.While these documents are useful in helping an end-user properly interpr... It is common practice for data providers to include text descriptions for each column when publishing data sets in the form of data dictionaries.While these documents are useful in helping an end-user properly interpret the meaning of a column in a data set,existing data dictionaries typically are not machine-readable and do not follow a common specification standard.We introduce the Semantic Data Dictionary,a specification that formalizes the assignment of a semantic representation of data,enabling standardization and harmonization across diverse data sets.In this paper,we present our Semantic Data Dictionary work in the context of our work with biomedical data;however,the approach can and has been used in a wide range of domains.The rendition of data in this form helps promote improved discovery,interoperability,reuse,traceability,and reproducibility.We present the associated research and describe how the Semantic Data Dictionary can help address existing limitations in the related literature.We discuss our approach,present an example by annotating portions of the publicly available National Health and Nutrition Examination Survey data set,present modeling challenges,and describe the use of this approach in sponsored research,including our work on a large National Institutes of Health(NIH)-funded exposure and health data portal and in the RPI-IBM collaborative Health Empowerment by Analytics,Learning,and Semantics project. 展开更多
关键词 Semantic Data Dictionary Dictionary mapping CODEBOOK Knowledge modeling Data integration Data dictionary Mapping language Metadata standard Semantic Web Semantic ETL FAIR DATA
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