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静息和活化内源性成年神经干细胞:身份确认与特性分析
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作者 王亚周 jennifer m.plane 江鹏 《医学争鸣》 CAS 北大核心 2012年第2期20-20,共1页
成年哺乳动物中枢神经系统缺乏再生能力,这一现象吸引了众多科学家的研究兴趣。成年神经干细胞的发现打破了成年大脑无新生神经元发生的传统结论,并激发了研究者梦想大脑“自我修复”的兴趣。不幸的是,成年神经干细胞的静息特性和低... 成年哺乳动物中枢神经系统缺乏再生能力,这一现象吸引了众多科学家的研究兴趣。成年神经干细胞的发现打破了成年大脑无新生神经元发生的传统结论,并激发了研究者梦想大脑“自我修复”的兴趣。不幸的是,成年神经干细胞的静息特性和低可塑性削弱了它们的再生潜能。 展开更多
关键词 成年神经干细胞 身份确认 静息 内源性 活化 中枢神经系统 成年哺乳动物 再生能力
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Vulnerability of premyelinating oligodendrocytes to white-matter damage in neonatal brain injury 被引量:17
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作者 Xiao-Bo Liu Yan Shen +1 位作者 jennifer m.plane Wenbin Deng 《Neuroscience Bulletin》 SCIE CAS CSCD 2013年第2期229-238,共10页
Premature birth is a significant economic and public health burden, and its incidence is rising. Periventricular leukomalacia (PVL) is the predominant form of brain injury in premature infants and the leading cause ... Premature birth is a significant economic and public health burden, and its incidence is rising. Periventricular leukomalacia (PVL) is the predominant form of brain injury in premature infants and the leading cause of cerebral palsy. PVL is characterized by selective white-matter damage with prominent oligodendroglial injury. The maturation-dependent vulnerability of developing and premyelinating oligodendrocytes to excitotoxic, oxidative, and inflammatory forms of injury is a major factor in the pathogenesis of PVL. Recent studies using mouse models of PVL reveal that synapses between axons and developing oligodendrocytes are quickly and profoundly damaged in immature white matter. Axon-glia synapses are highly vulnerable to white-matter injury in the developing brain, and the loss of synapses between axons and premyelinating oligodendrocytes occurs before any cellular loss in the immature white matter. Microglial activation and astrogliosis play important roles in triggering white-matter injury. Impairment of white-matter development and function in the neonatal period contributes critically to functional and behavioral deficits. Preservation of the integrity of the white matter is likely key in the treatment of PVL and subsequent neurological consequences and disabilities. 展开更多
关键词 PREMATURITY neonatal brain injury white matter OLIGODENDROCYTE MYELIN periventricular leukomalacia
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