Telomerase has fundamental roles in bypassing cellular aging and in cancer progression by maintaining telomere homeostasis and integrity. However, recent studies have led some investigators to suggest novel biochemica...Telomerase has fundamental roles in bypassing cellular aging and in cancer progression by maintaining telomere homeostasis and integrity. However, recent studies have led some investigators to suggest novel biochemical properties of telomerase in several essential cell signaling pathways without apparent involvement of its well established function in telomere maintenance. These observations may further enhance our understanding of the molecular actions of telomerase in aging and cancer. This review will provide an update on the extracurricular activities of telomerase in apoptosis, DNA repair, stern cell function, and in the regulation of gene expression.展开更多
基金Acknowledgments Research in author＇s lab was supported in part by a grant from the National Natural Science Foundation of China （No. 30671065）, the Research Fund for the Doctoral Program of High Education （No. 20060027008）, and the National Important Basic Research Project （No. 2007CB507402） to Yusheng Cong. Support from NASA grants NNJ06HD92G and NNJ05HD36G （JWS） is acknowledged.
文摘Telomerase has fundamental roles in bypassing cellular aging and in cancer progression by maintaining telomere homeostasis and integrity. However, recent studies have led some investigators to suggest novel biochemical properties of telomerase in several essential cell signaling pathways without apparent involvement of its well established function in telomere maintenance. These observations may further enhance our understanding of the molecular actions of telomerase in aging and cancer. This review will provide an update on the extracurricular activities of telomerase in apoptosis, DNA repair, stern cell function, and in the regulation of gene expression.
