"Celebrating the constant blue skies this winter,Beijing will move forward with a new phase of its environmental campaign of mixed controls on air pollution,focusing on vehicles with high exhaust levels".the..."Celebrating the constant blue skies this winter,Beijing will move forward with a new phase of its environmental campaign of mixed controls on air pollution,focusing on vehicles with high exhaust levels".the acting mayor said on Wednesday."Beijing will make every effort to maintain blue skies this year and will unveil the new action展开更多
BACKGROUND: Adipokines and inflammatory factors play an important role in disease progression. Two cardiovascular diseases which have important contributions to mortality and morbidity in China are in-tracerebral hemo...BACKGROUND: Adipokines and inflammatory factors play an important role in disease progression. Two cardiovascular diseases which have important contributions to mortality and morbidity in China are in-tracerebral hemorrhage (ICH) and myocardial infarction (MI). Acylation stimulating protein has been shown in North American populations to have strong associations with risk factors for MI. Complement C3 (C3) a component of the innate complement immune system is the precursor protein to ASP;C3 has been impli-cated in the pathogenesis of ICH. OBJECTIVE: In this case-control study we examined the association be-tween BMI, lipoproteins adiponectin, C3 and ASP) in a Chinese population. METHODS AND RESULTS: Three groups of subjects were studied: ICH group (N = 41), MI group (N = 60) and a control group (N = 44). There was no difference in BMI for either ICH or MI compared to controls (Control: 22.3 ± 0.3 kg/m2;ICH: 21.3 ± 0.4 vs MI: 22.5 ± 0.2, ICH and MI versus control pNS). The ICH group had lower LDL-C (Control: 3.21 ± 0.13 mmol/L;ICH: 2.54 ± 0.13;MI: 2.99 ± 0.13;ICH vs control p < 0.05), total cholesterol (Control: 5.06 ± 0.16 mmol/L;ICH: 4.40 ± 0.15;MI: 4.51 ± 0.14;ICH and MI vs control p < 0.05),, HDL-C (Control: 1.34 ± 0.05 mmol/L;ICH: 1.22 ± 0.06;MI: 0.95 ± 0.04;ICH and MI vs control p < 0.05), and C3 (Control: 2.58 ? 0.21 g/L;ICH: 1.85 ? 0.19;MI: 2.87 ? 0.16;ICH vs control p < 0.05), and higher TG (Control: 1.10 ± 0.07 mmol/L;ICH: 1.77 ± 0.17;MI: 1.61 ± 0.10, ICH and MI vs control p < 0.05), compared to the controls. The MI group had lower total cholesterol and HDL-C and higher TG and ASP (Control: 33.70 ? 2.07 nM;ICH: 35.10 ? 2.33;MI: 41.50 ? 1.81;MI vs control p < 0.05) compared to control. CONCLUSION: Chinese men and women who had an MI displayed elevated ASP unrelated to an increase in the precursor protein, C3. Chinese men and women with ICH had ASP levels similar to controls yet lower C3 suggesting that C3, and the regulation of C3 conversion to ASP may be important in ICH disease pathology.展开更多
Assisted reproductive technology (ART) laboratories represent the marriage of the most basic of biological activities with the most cutting edge technologies. While this association has worked well, the mixture of bio...Assisted reproductive technology (ART) laboratories represent the marriage of the most basic of biological activities with the most cutting edge technologies. While this association has worked well, the mixture of biology and technology can create risks to normal embryo development. Recently a significant amount of literature has explored the risks of manmade, electrically induced magnetic fields and carrier waves on reproduction, which some studies have suggested will lower functional gamete numbers in the males and potentially induce genetic issues in embryos. However, little is known about these phenomena within the ART laboratory, a laboratory filled with electronic equipment. The object of the present study was to explore the potential exposure of gametes and early stage embryos to two of the most prevalent fields and waves utilized in manmade technologies seen in the general environment, electromagnetic fields (EMF) and radio frequency waves (RF), and determine the effect varying levels of these energetic forces had on gamete function and embryo development. Results indicated that while extremely high concentrations of EMF (approximately 50-100X of laboratory background) caused negative outcomes in both gametes and embryos, levels consistent will the majority of lab equipment did not appear to impact growth, or function. Further, even extremely high RF appeared to have no impact cellular function. Results suggest few issues with EMF or RF on gamete and embryo function at normal laboratory levels for the relatively short exposure times seen in the ART laboratory.展开更多
文摘"Celebrating the constant blue skies this winter,Beijing will move forward with a new phase of its environmental campaign of mixed controls on air pollution,focusing on vehicles with high exhaust levels".the acting mayor said on Wednesday."Beijing will make every effort to maintain blue skies this year and will unveil the new action
文摘BACKGROUND: Adipokines and inflammatory factors play an important role in disease progression. Two cardiovascular diseases which have important contributions to mortality and morbidity in China are in-tracerebral hemorrhage (ICH) and myocardial infarction (MI). Acylation stimulating protein has been shown in North American populations to have strong associations with risk factors for MI. Complement C3 (C3) a component of the innate complement immune system is the precursor protein to ASP;C3 has been impli-cated in the pathogenesis of ICH. OBJECTIVE: In this case-control study we examined the association be-tween BMI, lipoproteins adiponectin, C3 and ASP) in a Chinese population. METHODS AND RESULTS: Three groups of subjects were studied: ICH group (N = 41), MI group (N = 60) and a control group (N = 44). There was no difference in BMI for either ICH or MI compared to controls (Control: 22.3 ± 0.3 kg/m2;ICH: 21.3 ± 0.4 vs MI: 22.5 ± 0.2, ICH and MI versus control pNS). The ICH group had lower LDL-C (Control: 3.21 ± 0.13 mmol/L;ICH: 2.54 ± 0.13;MI: 2.99 ± 0.13;ICH vs control p < 0.05), total cholesterol (Control: 5.06 ± 0.16 mmol/L;ICH: 4.40 ± 0.15;MI: 4.51 ± 0.14;ICH and MI vs control p < 0.05),, HDL-C (Control: 1.34 ± 0.05 mmol/L;ICH: 1.22 ± 0.06;MI: 0.95 ± 0.04;ICH and MI vs control p < 0.05), and C3 (Control: 2.58 ? 0.21 g/L;ICH: 1.85 ? 0.19;MI: 2.87 ? 0.16;ICH vs control p < 0.05), and higher TG (Control: 1.10 ± 0.07 mmol/L;ICH: 1.77 ± 0.17;MI: 1.61 ± 0.10, ICH and MI vs control p < 0.05), compared to the controls. The MI group had lower total cholesterol and HDL-C and higher TG and ASP (Control: 33.70 ? 2.07 nM;ICH: 35.10 ? 2.33;MI: 41.50 ? 1.81;MI vs control p < 0.05) compared to control. CONCLUSION: Chinese men and women who had an MI displayed elevated ASP unrelated to an increase in the precursor protein, C3. Chinese men and women with ICH had ASP levels similar to controls yet lower C3 suggesting that C3, and the regulation of C3 conversion to ASP may be important in ICH disease pathology.
文摘Assisted reproductive technology (ART) laboratories represent the marriage of the most basic of biological activities with the most cutting edge technologies. While this association has worked well, the mixture of biology and technology can create risks to normal embryo development. Recently a significant amount of literature has explored the risks of manmade, electrically induced magnetic fields and carrier waves on reproduction, which some studies have suggested will lower functional gamete numbers in the males and potentially induce genetic issues in embryos. However, little is known about these phenomena within the ART laboratory, a laboratory filled with electronic equipment. The object of the present study was to explore the potential exposure of gametes and early stage embryos to two of the most prevalent fields and waves utilized in manmade technologies seen in the general environment, electromagnetic fields (EMF) and radio frequency waves (RF), and determine the effect varying levels of these energetic forces had on gamete function and embryo development. Results indicated that while extremely high concentrations of EMF (approximately 50-100X of laboratory background) caused negative outcomes in both gametes and embryos, levels consistent will the majority of lab equipment did not appear to impact growth, or function. Further, even extremely high RF appeared to have no impact cellular function. Results suggest few issues with EMF or RF on gamete and embryo function at normal laboratory levels for the relatively short exposure times seen in the ART laboratory.
