Many phytochemicals and their derived metabolites produced by plants are extensively employed in commercial goods,pharmaceutical products as well as in the environmental and medicalfields.However,these secondary metabo...Many phytochemicals and their derived metabolites produced by plants are extensively employed in commercial goods,pharmaceutical products as well as in the environmental and medicalfields.However,these secondary metabolites obtained from plants are in low amounts,and it is difficult to synthesize them at the industrial level.Despite these challenges,they may be utilized for a variety of medicinal products that are either available in the market or are being researched and tested.Secondary metabolites are complex compounds that exhibit chirality.Further,under controlled conditions with elicitors,desired secondary metabolites may be produced from plant cell cultures.This review emphasizes the various aspects of secondary metabolites including their types,synthesis,and applications as medicinal products.The article aims to promote the use of plant secondary metabolites in the management and treatment of various diseases.展开更多
Colorectal cancer(CRC)is the third most prevalent cancer.Ongoing research aims to uncover the causes of CRC,with a growing focus on the role of gut microbiota(GM)in carcinogenesis.The GM influences CRC development,pro...Colorectal cancer(CRC)is the third most prevalent cancer.Ongoing research aims to uncover the causes of CRC,with a growing focus on the role of gut microbiota(GM)in carcinogenesis.The GM influences CRC development,progression,treatment efficacy,and therapeutic toxicities.For example,Fusobacterium nucleatum and Escherichia coli can regulate microbial gene expression through the incorporation of human small noncode RNA and potentially contribute to cancer progression.Metallic nanoparticles(MNPs)have both negative and positive impacts on GM,depending on their type.Several studies state that titanium dioxide may increase the diversity,richness,and abundance of probiotics bacteria,whereas other studies demonstrate dose‐dependent GM dysbiosis.The MNPs offer cytotoxicity through the modulation of MAPK signaling pathways,NF‐kB signaling pathways,PI3K/Akt signaling pathways,extrinsic signaling pathways,intrinsic apoptosis,and cell cycle arrest at G1,G2,or M phase.MNPs enhance drug delivery,enable targeted therapy,and may restore GM.However,there is a need to conduct well‐designed clinical trials to assess the toxicity,safety,and effectiveness of MNPs‐based CRC therapies.展开更多
文摘Many phytochemicals and their derived metabolites produced by plants are extensively employed in commercial goods,pharmaceutical products as well as in the environmental and medicalfields.However,these secondary metabolites obtained from plants are in low amounts,and it is difficult to synthesize them at the industrial level.Despite these challenges,they may be utilized for a variety of medicinal products that are either available in the market or are being researched and tested.Secondary metabolites are complex compounds that exhibit chirality.Further,under controlled conditions with elicitors,desired secondary metabolites may be produced from plant cell cultures.This review emphasizes the various aspects of secondary metabolites including their types,synthesis,and applications as medicinal products.The article aims to promote the use of plant secondary metabolites in the management and treatment of various diseases.
文摘Colorectal cancer(CRC)is the third most prevalent cancer.Ongoing research aims to uncover the causes of CRC,with a growing focus on the role of gut microbiota(GM)in carcinogenesis.The GM influences CRC development,progression,treatment efficacy,and therapeutic toxicities.For example,Fusobacterium nucleatum and Escherichia coli can regulate microbial gene expression through the incorporation of human small noncode RNA and potentially contribute to cancer progression.Metallic nanoparticles(MNPs)have both negative and positive impacts on GM,depending on their type.Several studies state that titanium dioxide may increase the diversity,richness,and abundance of probiotics bacteria,whereas other studies demonstrate dose‐dependent GM dysbiosis.The MNPs offer cytotoxicity through the modulation of MAPK signaling pathways,NF‐kB signaling pathways,PI3K/Akt signaling pathways,extrinsic signaling pathways,intrinsic apoptosis,and cell cycle arrest at G1,G2,or M phase.MNPs enhance drug delivery,enable targeted therapy,and may restore GM.However,there is a need to conduct well‐designed clinical trials to assess the toxicity,safety,and effectiveness of MNPs‐based CRC therapies.
