The main problems of the traditional software talent training are that the knowledge learned is out of touch of the industry,weak ability to solve complex engineering problems and the comprehensive quality cannot meet...The main problems of the traditional software talent training are that the knowledge learned is out of touch of the industry,weak ability to solve complex engineering problems and the comprehensive quality cannot meet the requirements of enterprises.Taking the course of digital image processing as an example,this paper analyzes the key steps in the training process in details,and proposes a multiple mode collaborative based software engineering talent training mechanism,which brings the key subjects of teaching materials,teachers,students,enterprises,subjects into a unified training mechanism,so as to provide a new ideas for software talent teaching.展开更多
Asiatic acid(AA), a pentacyclic triterpene found in Centella asiatica, displays significant antiproliferative effects on cancer cells in vitro although the underlying mechanism of this effect remains unknown. This stu...Asiatic acid(AA), a pentacyclic triterpene found in Centella asiatica, displays significant antiproliferative effects on cancer cells in vitro although the underlying mechanism of this effect remains unknown. This study investigated the efficacy and mechanism of action of AA against lung cancer both in vivo and in vitro. Using the MTT assay, AA was found to induce apoptosis in a dose- and timedependent manner, an effect enhanced by pretreatment with an autophagy inhibitor. It also elevated expression of microtubule-associated protein 1 light chain 3(LC3) and decreased the expression of p62.Furthermore, exposure to AA resulted in collapse of the mitochondrial membrane potential and generation of reactive oxygen species(ROS), suggesting mitochondria are the target of AA. In the mouse lung cancer xenograft model, oral administration of AA significantly inhibited tumor volume and weight accompanied by significant apoptosis of lung cancer cells. In addition, it led to a significant decrease in the expression of proliferating cell nuclear antigen(PCNA). In summary, the results show that AA significantly reduces lung cancer cell growth both in vitro and in vivo and that the associated apoptosis is mediated through mitochondrial damage.展开更多
文摘The main problems of the traditional software talent training are that the knowledge learned is out of touch of the industry,weak ability to solve complex engineering problems and the comprehensive quality cannot meet the requirements of enterprises.Taking the course of digital image processing as an example,this paper analyzes the key steps in the training process in details,and proposes a multiple mode collaborative based software engineering talent training mechanism,which brings the key subjects of teaching materials,teachers,students,enterprises,subjects into a unified training mechanism,so as to provide a new ideas for software talent teaching.
文摘Asiatic acid(AA), a pentacyclic triterpene found in Centella asiatica, displays significant antiproliferative effects on cancer cells in vitro although the underlying mechanism of this effect remains unknown. This study investigated the efficacy and mechanism of action of AA against lung cancer both in vivo and in vitro. Using the MTT assay, AA was found to induce apoptosis in a dose- and timedependent manner, an effect enhanced by pretreatment with an autophagy inhibitor. It also elevated expression of microtubule-associated protein 1 light chain 3(LC3) and decreased the expression of p62.Furthermore, exposure to AA resulted in collapse of the mitochondrial membrane potential and generation of reactive oxygen species(ROS), suggesting mitochondria are the target of AA. In the mouse lung cancer xenograft model, oral administration of AA significantly inhibited tumor volume and weight accompanied by significant apoptosis of lung cancer cells. In addition, it led to a significant decrease in the expression of proliferating cell nuclear antigen(PCNA). In summary, the results show that AA significantly reduces lung cancer cell growth both in vitro and in vivo and that the associated apoptosis is mediated through mitochondrial damage.
