The development of boceprevir and telaprevir was a major step forward in the treatment of chronic hepatitis C.In addition,the treatment of these infections has been recently revolutionized by the approval of sofosbuvi...The development of boceprevir and telaprevir was a major step forward in the treatment of chronic hepatitis C.In addition,the treatment of these infections has been recently revolutionized by the approval of sofosbuvir and simeprevir.However,there are several challenges associated with the application of noveldrugs,such as new and more frequent adverse events,new drug interactions,and excessively high treatment costs.An additional concern is viral resistance.These considerations highlight the fact that direct-acting antiviral agents are not a panacea and may not be the best option for all patients who are in need of therapy.This retrospective study revealed that the sustained virologic response was not significantly reduced following peginterferon and ribavirin retreatment compared with the new therapy.We suggest that patients who experience relapse shortly after completing treatment with peginterferon and ribavirin have a reasonable chance of achieving a sustained virologic response when retreated with these drugs alone.展开更多
Nonconvulsive status epilepticus has become an important issue in modern neurology and epileptology.This is based on difficulty in definitively elucidating thecondition and its various clinical phenomena and on our in...Nonconvulsive status epilepticus has become an important issue in modern neurology and epileptology.This is based on difficulty in definitively elucidating thecondition and its various clinical phenomena and on our inadequate insight into the intrinsic pathophysiological processes.Despite nonconvulsive status epilepticus being a situation that requires immediate treatment,this disorder may not be appreciated as the cause of mental status impairment.Although the pathophysiology of nonconvulsive status epilepticus remains unknown,this disorder is thought to lead to neuronal damage,so its identification and treatment are important.Nonconvulsive status epilepticus should be considered in the differential diagnosis of patients with liver cirrhosis presenting an altered mental status.We report a case of a 52-year-old male with liver cirrhosis presenting an altered mental status.He was initially diagnosed with hepatic encephalopathy but ultimately diagnosed with nonconvulsive status epilepticus by electroencephalogram.展开更多
文摘The development of boceprevir and telaprevir was a major step forward in the treatment of chronic hepatitis C.In addition,the treatment of these infections has been recently revolutionized by the approval of sofosbuvir and simeprevir.However,there are several challenges associated with the application of noveldrugs,such as new and more frequent adverse events,new drug interactions,and excessively high treatment costs.An additional concern is viral resistance.These considerations highlight the fact that direct-acting antiviral agents are not a panacea and may not be the best option for all patients who are in need of therapy.This retrospective study revealed that the sustained virologic response was not significantly reduced following peginterferon and ribavirin retreatment compared with the new therapy.We suggest that patients who experience relapse shortly after completing treatment with peginterferon and ribavirin have a reasonable chance of achieving a sustained virologic response when retreated with these drugs alone.
文摘Nonconvulsive status epilepticus has become an important issue in modern neurology and epileptology.This is based on difficulty in definitively elucidating thecondition and its various clinical phenomena and on our inadequate insight into the intrinsic pathophysiological processes.Despite nonconvulsive status epilepticus being a situation that requires immediate treatment,this disorder may not be appreciated as the cause of mental status impairment.Although the pathophysiology of nonconvulsive status epilepticus remains unknown,this disorder is thought to lead to neuronal damage,so its identification and treatment are important.Nonconvulsive status epilepticus should be considered in the differential diagnosis of patients with liver cirrhosis presenting an altered mental status.We report a case of a 52-year-old male with liver cirrhosis presenting an altered mental status.He was initially diagnosed with hepatic encephalopathy but ultimately diagnosed with nonconvulsive status epilepticus by electroencephalogram.
