Adrenocorticotropic hormone is recommended worldwide as an initial therapy for infantile spasms. However, infantile spasms in about 50% of children cannot be fully controlled by adrenocorticotropic hormone monotherapy...Adrenocorticotropic hormone is recommended worldwide as an initial therapy for infantile spasms. However, infantile spasms in about 50% of children cannot be fully controlled by adrenocorticotropic hormone monotherapy, seizures recur in 33% of patients who initially respond to adrenocorticotropic hormone monotherapy, and side effects are relatively common during adrenocorticotropic hormone treatment. Topiramate, vitamin B6, and immunoglobulin are effective in some children with infantile spasms. In the present study, we hypothesized that combined therapy with adrenocorticotropic hormone, topiramate, vitamin B6, and immunoglobulin would effectively treat infantile spasms and have mild adverse effects. Thus, 51 children newly diagnosed with West syndrome including infantile spasms were enrolled and underwent polytherapy with the four drugs. Electroencephalographic hypsarrhythmia was significantly improved in a majority of patients, and these patients were seizure-free, had mild side effects, and low recurrence rates. The overall rates of effective treatment and loss of seizures were significantly higher in cryptogenic children compared with symptomatic children. The mean time to loss of seizures in cryptogenic children was significantly shorter than in symptomatic patients. These findings indicate that initial polytherapy with adrenocorticotropic hormone, topiramate, vitamin Be, and immunoglobulin effectively improves the prognosis of infantile spasms, and its effects were superior in cryptogenic children to symptomatic children.展开更多
A new development of indirect gating case in the differential decay curve method used for lifetime measurement has been introduced.The gate region was extended from partial shifted peak to both shifted and unshifted c...A new development of indirect gating case in the differential decay curve method used for lifetime measurement has been introduced.The gate region was extended from partial shifted peak to both shifted and unshifted components.The statistics of flight and stop peaks in gating spectra was improved obviously.The reliability of this change has been tested by reanalysing the lifetime of 2^+ state in^(134) Ce.The result of 32.2(33) ps was fit well with the previous published values within the experimental uncertainty.The developed method was also used to analyse the lifetime of 2_1^+ state in^(138) Nd.展开更多
BACKGROUND A prostatic stromal tumor is deemed to be a rare oncology condition.Based on the retrospective analysis of clinical data and scientific literature review,a case of prostatic stromal tumor was reported in th...BACKGROUND A prostatic stromal tumor is deemed to be a rare oncology condition.Based on the retrospective analysis of clinical data and scientific literature review,a case of prostatic stromal tumor was reported in this article to explore the diagnosis,treatment and prognosis of this rare disease.CASE SUMMARY The present case involved an older male patient who was admitted to our department for a medical consultation of dysuria.Serum prostate-specific antigen was 8.30 ng/mL,Ultrasound and magnetic resonance imaging suggested evident enlargement of the prostate and multiple cystic developments internally.Considering that the patient was an elderly male with a poor health status,transurethral resection of the prostate was performed to improve the symptoms of urinary tract obstruction.Furthermore,based on histopathologic examination and immunohistochemical staining,the patient was pathologically diagnosed with prostatic stromal tumor.The patient did not receive any further adjuvant therapy following surgery leading to a clinical recommendation that the patient should be followed up on a long-term basis.However,during the recent follow-up assessment,the patient demonstrated recurrence of lower urinary tract symptoms and gross hematuria.CONCLUSION Referring to scientific literature review,we believe that the management of these lesions requires a thorough assessment of the patient.Furthermore,the treatment of prostate stromal tumors should be based on the imaging examination andpathological classification. Active surgical treatment is of great significance to theprognosis of patients, and subsequent surveillance after the treatment iswarranted.展开更多
BACKGROUND Hem-o-Lok clip(HOLC)has been widely used in laparoscopic surgery due to its ease of application and secure clamping,though the rare complications associated with this technique should not be ignored.The rar...BACKGROUND Hem-o-Lok clip(HOLC)has been widely used in laparoscopic surgery due to its ease of application and secure clamping,though the rare complications associated with this technique should not be ignored.The rare complications of laparoscopic partial nephrectomy consist of the clip migrating into the renal pelvis and acting as a nidus for stone formation.CASE SUMMARY The case described here involved a 63-year-old woman who was found with stones in the right kidney and upper ureter during a recent reexamination following laparoscopic partial nephrectomy.We performed percutaneous nephrolithotomy for her,but during the operation,it was found that the center of the stone within the kidney was a HOLC,which was removed with forceps.For this reason,we speculate that the HOLC,which was employed to halt tumor wound bleeding,spontaneously drifted into the renal pelvis and formed kidney stones,with the clip being initially misdiagnosed as a kidney stone.CONCLUSION By reviewing related case reports,we conclude that in order to prevent complications related to HOLC,loose clips should be actively searched for and retrieved from the wound during urinary tract surgery,while the deployment of clips in close proximity of anastomotic stoma of collecting systems should be avoided.展开更多
Electrochemical water splitting is quite seductive for eco-friendly hydrogen fuel energy production,however,the attainment of highly efficient,durable,and cheap catalysts for the hydrogen evolution reaction(HER)remain...Electrochemical water splitting is quite seductive for eco-friendly hydrogen fuel energy production,however,the attainment of highly efficient,durable,and cheap catalysts for the hydrogen evolution reaction(HER)remains challenging.In this study,molybdenum oxides stabilized palladium nanoparticle catalysts(MoO_(x)-Pd)are in situ prepared on commercial carbon cloth(CC)by the facile two-step method of dip-coating and electrochemical reduction.As a self-supported Pd-based catalyst electrode,the MoO_(x)-Pd/CC presents a competitive Tafel slope of 45.75 mV·dec^(-1),an ultralow overpotential of 25 mV,and extremely long cycling durability(one week)in 0.5M H_(2)S0_(4)electrolyte,superior to unmodified Pd catalysts and comparable to commercial Pt mesh electrode.On the one hand,the introduction of MoO_(x)can inhibit the growth of Pd particles to obtain ultrafine Pd nanoparticles,thus exposing more available active sites.On the other hand,density functional theory(DFT)calculation revealed that MoO_(x)on the surface of Pd metal can regulate the electronic structure of Pd metal and enhance its intrinsic catalytic activity of HER.This work suggests that transitional metal nanoparticles stabilized by molybdenum oxides are hopeful approaches for obtaining fruitful hydrogen-producing electrocatalysts.展开更多
On September 20 th, 2015, twenty satellites were successfully deployed into a near-polar circular orbit at 520 km altitude by the Chinese CZ-6 test rocket, which was launched from the Tai Yuan Satellite Launch Center....On September 20 th, 2015, twenty satellites were successfully deployed into a near-polar circular orbit at 520 km altitude by the Chinese CZ-6 test rocket, which was launched from the Tai Yuan Satellite Launch Center. Among these satellites, a set of 4 Cube Sats conform the atmospheric density detection and precise orbit determination(APOD) mission, which is projected for atmospheric density estimation from in-situ detection and precise orbit products. The APOD satellites are manufactured by China Spacesat Co. Ltd. and the payload instruments include an atmospheric density detector(ADD), a dual-frequency dualmode global navigation satellite system(GNSS) receiver(GPS and Beidou), a satellite laser ranging(SLR) reflector, and an S/Xband very long baseline interferometry(VLBI) beacon. In this paper, we compare the GNSS precise orbit products with colocated SLR observations, and the 3 D orbit accuracy shows better than 10 cm RMS. These results reveal the great potential of the onboard micro-electro-mechanical system(MEMS) GNSS receiver. After calibrating ADD density estimates with precise orbit products, the accuracy of our density products can reach about 10% with respect to the background density. Density estimates from APOD are of a great importance for scientific studies on upper atmosphere variations and useful for model data assimilation.展开更多
The lifetime of the 2^+1 state in ^106Cd populated via the ^94Zr(^16O,4n)^106Cd reaction has been measured with the Recoil Distance Doppler Shift technique in combination with the Differential Decay Curve Method.By su...The lifetime of the 2^+1 state in ^106Cd populated via the ^94Zr(^16O,4n)^106Cd reaction has been measured with the Recoil Distance Doppler Shift technique in combination with the Differential Decay Curve Method.By subtracting the contamination in the data,the mean lifetime of the I^π=2^+1633 keV state was determined as 9.9(12)ps.The B(E2)value calculated in this study is in good agreement with the experimental systematics and was compared to the shell model calculations.展开更多
文摘Adrenocorticotropic hormone is recommended worldwide as an initial therapy for infantile spasms. However, infantile spasms in about 50% of children cannot be fully controlled by adrenocorticotropic hormone monotherapy, seizures recur in 33% of patients who initially respond to adrenocorticotropic hormone monotherapy, and side effects are relatively common during adrenocorticotropic hormone treatment. Topiramate, vitamin B6, and immunoglobulin are effective in some children with infantile spasms. In the present study, we hypothesized that combined therapy with adrenocorticotropic hormone, topiramate, vitamin B6, and immunoglobulin would effectively treat infantile spasms and have mild adverse effects. Thus, 51 children newly diagnosed with West syndrome including infantile spasms were enrolled and underwent polytherapy with the four drugs. Electroencephalographic hypsarrhythmia was significantly improved in a majority of patients, and these patients were seizure-free, had mild side effects, and low recurrence rates. The overall rates of effective treatment and loss of seizures were significantly higher in cryptogenic children compared with symptomatic children. The mean time to loss of seizures in cryptogenic children was significantly shorter than in symptomatic patients. These findings indicate that initial polytherapy with adrenocorticotropic hormone, topiramate, vitamin Be, and immunoglobulin effectively improves the prognosis of infantile spasms, and its effects were superior in cryptogenic children to symptomatic children.
基金supported by the National Natural Science Foundation of China(No.11475072,11375267,11305269,11405274,11405072,11205069,11775307,11375266,11575118 and 11605114)the National Natural Science Foundation of Guangdong,China(No.2016A030310042)+1 种基金the National Key Research and Development Program of Chinathe National Key Scientific Instrument and Equipment Development Projects,China(No.2017YFF0106501)
文摘A new development of indirect gating case in the differential decay curve method used for lifetime measurement has been introduced.The gate region was extended from partial shifted peak to both shifted and unshifted components.The statistics of flight and stop peaks in gating spectra was improved obviously.The reliability of this change has been tested by reanalysing the lifetime of 2^+ state in^(134) Ce.The result of 32.2(33) ps was fit well with the previous published values within the experimental uncertainty.The developed method was also used to analyse the lifetime of 2_1^+ state in^(138) Nd.
文摘BACKGROUND A prostatic stromal tumor is deemed to be a rare oncology condition.Based on the retrospective analysis of clinical data and scientific literature review,a case of prostatic stromal tumor was reported in this article to explore the diagnosis,treatment and prognosis of this rare disease.CASE SUMMARY The present case involved an older male patient who was admitted to our department for a medical consultation of dysuria.Serum prostate-specific antigen was 8.30 ng/mL,Ultrasound and magnetic resonance imaging suggested evident enlargement of the prostate and multiple cystic developments internally.Considering that the patient was an elderly male with a poor health status,transurethral resection of the prostate was performed to improve the symptoms of urinary tract obstruction.Furthermore,based on histopathologic examination and immunohistochemical staining,the patient was pathologically diagnosed with prostatic stromal tumor.The patient did not receive any further adjuvant therapy following surgery leading to a clinical recommendation that the patient should be followed up on a long-term basis.However,during the recent follow-up assessment,the patient demonstrated recurrence of lower urinary tract symptoms and gross hematuria.CONCLUSION Referring to scientific literature review,we believe that the management of these lesions requires a thorough assessment of the patient.Furthermore,the treatment of prostate stromal tumors should be based on the imaging examination andpathological classification. Active surgical treatment is of great significance to theprognosis of patients, and subsequent surveillance after the treatment iswarranted.
文摘BACKGROUND Hem-o-Lok clip(HOLC)has been widely used in laparoscopic surgery due to its ease of application and secure clamping,though the rare complications associated with this technique should not be ignored.The rare complications of laparoscopic partial nephrectomy consist of the clip migrating into the renal pelvis and acting as a nidus for stone formation.CASE SUMMARY The case described here involved a 63-year-old woman who was found with stones in the right kidney and upper ureter during a recent reexamination following laparoscopic partial nephrectomy.We performed percutaneous nephrolithotomy for her,but during the operation,it was found that the center of the stone within the kidney was a HOLC,which was removed with forceps.For this reason,we speculate that the HOLC,which was employed to halt tumor wound bleeding,spontaneously drifted into the renal pelvis and formed kidney stones,with the clip being initially misdiagnosed as a kidney stone.CONCLUSION By reviewing related case reports,we conclude that in order to prevent complications related to HOLC,loose clips should be actively searched for and retrieved from the wound during urinary tract surgery,while the deployment of clips in close proximity of anastomotic stoma of collecting systems should be avoided.
基金the Natural Science Foundation of China(Nos.51902312,51672277)the young project of Anhui Provincial Natural Science Foundation(No.1908085QB83)+1 种基金the China Postdoctoral Science Foundation funded project(No.2019M652224)the CAS Pioneer Hundred Talents Program,and the CAS/SAFEA International Partnership Program for Creative Research Teams of Chinese Academy of Sciences,China.
文摘Electrochemical water splitting is quite seductive for eco-friendly hydrogen fuel energy production,however,the attainment of highly efficient,durable,and cheap catalysts for the hydrogen evolution reaction(HER)remains challenging.In this study,molybdenum oxides stabilized palladium nanoparticle catalysts(MoO_(x)-Pd)are in situ prepared on commercial carbon cloth(CC)by the facile two-step method of dip-coating and electrochemical reduction.As a self-supported Pd-based catalyst electrode,the MoO_(x)-Pd/CC presents a competitive Tafel slope of 45.75 mV·dec^(-1),an ultralow overpotential of 25 mV,and extremely long cycling durability(one week)in 0.5M H_(2)S0_(4)electrolyte,superior to unmodified Pd catalysts and comparable to commercial Pt mesh electrode.On the one hand,the introduction of MoO_(x)can inhibit the growth of Pd particles to obtain ultrafine Pd nanoparticles,thus exposing more available active sites.On the other hand,density functional theory(DFT)calculation revealed that MoO_(x)on the surface of Pd metal can regulate the electronic structure of Pd metal and enhance its intrinsic catalytic activity of HER.This work suggests that transitional metal nanoparticles stabilized by molybdenum oxides are hopeful approaches for obtaining fruitful hydrogen-producing electrocatalysts.
基金supported by the National Natural Science Foundation of China(Grant Nos.41874183,41474131&41604131)
文摘On September 20 th, 2015, twenty satellites were successfully deployed into a near-polar circular orbit at 520 km altitude by the Chinese CZ-6 test rocket, which was launched from the Tai Yuan Satellite Launch Center. Among these satellites, a set of 4 Cube Sats conform the atmospheric density detection and precise orbit determination(APOD) mission, which is projected for atmospheric density estimation from in-situ detection and precise orbit products. The APOD satellites are manufactured by China Spacesat Co. Ltd. and the payload instruments include an atmospheric density detector(ADD), a dual-frequency dualmode global navigation satellite system(GNSS) receiver(GPS and Beidou), a satellite laser ranging(SLR) reflector, and an S/Xband very long baseline interferometry(VLBI) beacon. In this paper, we compare the GNSS precise orbit products with colocated SLR observations, and the 3 D orbit accuracy shows better than 10 cm RMS. These results reveal the great potential of the onboard micro-electro-mechanical system(MEMS) GNSS receiver. After calibrating ADD density estimates with precise orbit products, the accuracy of our density products can reach about 10% with respect to the background density. Density estimates from APOD are of a great importance for scientific studies on upper atmosphere variations and useful for model data assimilation.
基金Supported by National Key Research and Development Program of China(2017YFF0106501)National Natural Science Foundation of China(11905134,11975315,U1932209,11575118,11605114)+3 种基金NSFC-CNNC Joint Project for Nuclear Technology Innovation(U1867210)Continuous Basic Scientific Research Project(WDJC-2019-13)Project funded by China Post-doctoral Science Foundation(2019M652999)and National Natural Science Foundation of Guangdong China(2016A030310042)。
文摘The lifetime of the 2^+1 state in ^106Cd populated via the ^94Zr(^16O,4n)^106Cd reaction has been measured with the Recoil Distance Doppler Shift technique in combination with the Differential Decay Curve Method.By subtracting the contamination in the data,the mean lifetime of the I^π=2^+1633 keV state was determined as 9.9(12)ps.The B(E2)value calculated in this study is in good agreement with the experimental systematics and was compared to the shell model calculations.
