The Chinese like tea and famous teas in particular. Tea drinking is an elegant custom and famous teas are often linked to legends, emperors, men of letters or renowned mountains, adding charm to Chinese culture. Longj...The Chinese like tea and famous teas in particular. Tea drinking is an elegant custom and famous teas are often linked to legends, emperors, men of letters or renowned mountains, adding charm to Chinese culture. Longjing (Drangon Well) Tea. The Book of Tea recorded tea produced in the Tianzhu and Lingvin temples in展开更多
Chestnuts are a kind of nut and are popular with all ages. When you pass food shops in Beijing in autumn or winter, a sweet and warm smell meals the nostrils. It makes the mouth water and one cannot help buying a bag ...Chestnuts are a kind of nut and are popular with all ages. When you pass food shops in Beijing in autumn or winter, a sweet and warm smell meals the nostrils. It makes the mouth water and one cannot help buying a bag of chestnuts, roasted in sand with brown sugar. It is no exaggeration to say that chestnuts are the king of nuts. China has a long history of chestnut cultivation. A chestnut fossil was展开更多
目的依托山东省胶南市“全人群高血压、糖尿病综合防治项目”建立队列,借助靶向最大似然估计(targeted maximum likelihood estimation,TMLE)模型评价高血压患者服用卡托普利或尼群地平对血压控制的平均因果效应和个体化因果效应,在大...目的依托山东省胶南市“全人群高血压、糖尿病综合防治项目”建立队列,借助靶向最大似然估计(targeted maximum likelihood estimation,TMLE)模型评价高血压患者服用卡托普利或尼群地平对血压控制的平均因果效应和个体化因果效应,在大数据背景下辅助精准医疗以实现高血压控制。方法筛选只服用卡托普利或尼群地平的患者,将其第一次随访血压控制情况作为结局,将年龄、性别、职业、BMI、吸烟、饮酒及运动情况纳入分析,采用嵌入Super Learner组合预测算法的靶向最大似然估计模型拟合条件均值结果的初始估计并进行波动,更新初始拟合,对目标参数做出最优偏差-方差权衡优化模型,从而得到平均因果效应,并进一步分析个体化因果效应。结果共纳入13676名高血压患者。总体上相比服用卡托普利,服用尼群地平更有利于血压控制(OR=1.24,95%CI:1.13~1.35,P=0.004)。从个体净效应来看,98.65%的患者使用尼群地平的血压控制效果更好。结论靶向最大似然估计模型能够分析平均因果效应和个性化因果效应,为现实世界的因果推断研究提供方法借鉴。展开更多
文摘The Chinese like tea and famous teas in particular. Tea drinking is an elegant custom and famous teas are often linked to legends, emperors, men of letters or renowned mountains, adding charm to Chinese culture. Longjing (Drangon Well) Tea. The Book of Tea recorded tea produced in the Tianzhu and Lingvin temples in
文摘Chestnuts are a kind of nut and are popular with all ages. When you pass food shops in Beijing in autumn or winter, a sweet and warm smell meals the nostrils. It makes the mouth water and one cannot help buying a bag of chestnuts, roasted in sand with brown sugar. It is no exaggeration to say that chestnuts are the king of nuts. China has a long history of chestnut cultivation. A chestnut fossil was
文摘目的依托山东省胶南市“全人群高血压、糖尿病综合防治项目”建立队列,借助靶向最大似然估计(targeted maximum likelihood estimation,TMLE)模型评价高血压患者服用卡托普利或尼群地平对血压控制的平均因果效应和个体化因果效应,在大数据背景下辅助精准医疗以实现高血压控制。方法筛选只服用卡托普利或尼群地平的患者,将其第一次随访血压控制情况作为结局,将年龄、性别、职业、BMI、吸烟、饮酒及运动情况纳入分析,采用嵌入Super Learner组合预测算法的靶向最大似然估计模型拟合条件均值结果的初始估计并进行波动,更新初始拟合,对目标参数做出最优偏差-方差权衡优化模型,从而得到平均因果效应,并进一步分析个体化因果效应。结果共纳入13676名高血压患者。总体上相比服用卡托普利,服用尼群地平更有利于血压控制(OR=1.24,95%CI:1.13~1.35,P=0.004)。从个体净效应来看,98.65%的患者使用尼群地平的血压控制效果更好。结论靶向最大似然估计模型能够分析平均因果效应和个性化因果效应,为现实世界的因果推断研究提供方法借鉴。
