Here we report a novel polymeric nanogel with stable loading cargo and near-infrared(NIR) controlled release properties.The nanogels are crosslinked by quaternization reactions of biocompatible poly(β-amino esters) a...Here we report a novel polymeric nanogel with stable loading cargo and near-infrared(NIR) controlled release properties.The nanogels are crosslinked by quaternization reactions of biocompatible poly(β-amino esters) and diselenide-bonded crosslinker(DSe DCl) in microemulsions.The hydrophobic cavities of the nanogels have the property of stably encapsulating the hydrophobic guest molecules,resulted from the crosslinked network structure.Due to the redox responsiveness of the diselenide bonds on the DSe DCl crosslinker,the nanogels can respond to oxidant H_(2)O_(2) causing the disintegration of the crosslinked network structure,thus the encapsulated guest cargo molecules will be released.It is noted that,upon loading the photosensitizer IR780,the nanogels can generate reactive oxygen species(ROS) under NIR irradiation to release the cargo.The advantages of encapsulated cargo stability enhanced by chemical cross-linking and remote stimulation response performance via NIR offer great potential of nanogels for applications of cargo controlled release.展开更多
基金financially supported by the National Natural Science Foundation of China (No. 51373025)the Program for New Century Excellent Talents in University (No. NCET-110582)。
文摘Here we report a novel polymeric nanogel with stable loading cargo and near-infrared(NIR) controlled release properties.The nanogels are crosslinked by quaternization reactions of biocompatible poly(β-amino esters) and diselenide-bonded crosslinker(DSe DCl) in microemulsions.The hydrophobic cavities of the nanogels have the property of stably encapsulating the hydrophobic guest molecules,resulted from the crosslinked network structure.Due to the redox responsiveness of the diselenide bonds on the DSe DCl crosslinker,the nanogels can respond to oxidant H_(2)O_(2) causing the disintegration of the crosslinked network structure,thus the encapsulated guest cargo molecules will be released.It is noted that,upon loading the photosensitizer IR780,the nanogels can generate reactive oxygen species(ROS) under NIR irradiation to release the cargo.The advantages of encapsulated cargo stability enhanced by chemical cross-linking and remote stimulation response performance via NIR offer great potential of nanogels for applications of cargo controlled release.
