Two new harziane diterpenoids, named（9R,10R）-dihydro-harzianone（1） and harzianelactone（2）, were isolated from the endophytic fungus Trichoderma sp. Xy24 by using various column chromatography techniques. Their s...Two new harziane diterpenoids, named（9R,10R）-dihydro-harzianone（1） and harzianelactone（2）, were isolated from the endophytic fungus Trichoderma sp. Xy24 by using various column chromatography techniques. Their structures were determined on the basis of extensive spectroscopic（HR-ESI-MS, 1D NMR, 2D NMR and CD） analyses. Among them, 1 was the reductive product of harzianone and 2 was the Baeyer–Villiger monooxygenase catalyzed oxidation product of harzianone. Compound 1 exhibited cytotoxic activity against He La and MCF-7 cell lines with IC（50） values of 30.1 μmol/L and 30.7 μmol/L,respectively.展开更多
The microbial transformation of glycyrrhetinic acid（1） by Cunninghamella blakesleana CGMCC 3.970 led to the production of five new metabolites（2-6）.The structures of the metabolites were determined by extensive sp...The microbial transformation of glycyrrhetinic acid（1） by Cunninghamella blakesleana CGMCC 3.970 led to the production of five new metabolites（2-6）.The structures of the metabolites were determined by extensive spectroscopic（HR-ESIMS,1D and 2D NMR） data analyses.The involved reactions exhibited specific hydroxylations at C-24,C-7,and C-15,and oxidation at C-3.Moreover,compounds 2,5,and 6showed significant neural anti-inflammatory activity by inhibiting lipopolysaccharide-induced NO production in mouse microglia BV2 cells with IC（50） values of 0.76,0.94,and 0.16μmol/L,respectively.展开更多
Periconones B-E（1-4）,four new polyketide-terpenoid hybrid molecules were isolated from the endophytic fungus Periconia sp.F-31.Their structures and absolute configurations were established by extensive spectroscopic...Periconones B-E（1-4）,four new polyketide-terpenoid hybrid molecules were isolated from the endophytic fungus Periconia sp.F-31.Their structures and absolute configurations were established by extensive spectroscopic data analysis and electronic circular dichroism（ECD）.Compound 4 exhibited in vitro cytotoxic activity against the human MCF-7 tumor cell line with an IC_（50） value of 4.2 μmol/L,and compound 1 displayed anti-HIV activity with an IC_（50） value of 18.0 μmol/L.展开更多
A new polyketide synthase-nonribosomal peptide synthetase （PKS-NRPS） hybrid metabolite, named pericoannosin B （1）, was isolated from endophytic fungus Periconia sp. F-31 of the medicinal plant Annona rnuricata. Th...A new polyketide synthase-nonribosomal peptide synthetase （PKS-NRPS） hybrid metabolite, named pericoannosin B （1）, was isolated from endophytic fungus Periconia sp. F-31 of the medicinal plant Annona rnuricata. The structure and absolute configuration were elucidated by means of extensive spectroscopic analyses （HRMS, NMR, IR, and CD）.展开更多
基金supported by the Science & Technology Project of Guangdong Province (No. 2011A080403020)
文摘Two new harziane diterpenoids, named（9R,10R）-dihydro-harzianone（1） and harzianelactone（2）, were isolated from the endophytic fungus Trichoderma sp. Xy24 by using various column chromatography techniques. Their structures were determined on the basis of extensive spectroscopic（HR-ESI-MS, 1D NMR, 2D NMR and CD） analyses. Among them, 1 was the reductive product of harzianone and 2 was the Baeyer–Villiger monooxygenase catalyzed oxidation product of harzianone. Compound 1 exhibited cytotoxic activity against He La and MCF-7 cell lines with IC（50） values of 30.1 μmol/L and 30.7 μmol/L,respectively.
文摘The microbial transformation of glycyrrhetinic acid（1） by Cunninghamella blakesleana CGMCC 3.970 led to the production of five new metabolites（2-6）.The structures of the metabolites were determined by extensive spectroscopic（HR-ESIMS,1D and 2D NMR） data analyses.The involved reactions exhibited specific hydroxylations at C-24,C-7,and C-15,and oxidation at C-3.Moreover,compounds 2,5,and 6showed significant neural anti-inflammatory activity by inhibiting lipopolysaccharide-induced NO production in mouse microglia BV2 cells with IC（50） values of 0.76,0.94,and 0.16μmol/L,respectively.
文摘Periconones B-E（1-4）,four new polyketide-terpenoid hybrid molecules were isolated from the endophytic fungus Periconia sp.F-31.Their structures and absolute configurations were established by extensive spectroscopic data analysis and electronic circular dichroism（ECD）.Compound 4 exhibited in vitro cytotoxic activity against the human MCF-7 tumor cell line with an IC_（50） value of 4.2 μmol/L,and compound 1 displayed anti-HIV activity with an IC_（50） value of 18.0 μmol/L.
基金financially supported by the National Natural Science Foundation of China (Nos. 31170041 and 81402835)the National High Technology Research and Development Program of China (No. 2012AA091606)The National Infrastructure of Microbial Resources (No. NIMR-2015-3)
文摘A new polyketide synthase-nonribosomal peptide synthetase （PKS-NRPS） hybrid metabolite, named pericoannosin B （1）, was isolated from endophytic fungus Periconia sp. F-31 of the medicinal plant Annona rnuricata. The structure and absolute configuration were elucidated by means of extensive spectroscopic analyses （HRMS, NMR, IR, and CD）.
