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Impact of non-oncological factors on tumor recurrence after liver transplantation in hepatocellular carcinoma patients 被引量:7
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作者 Xiang-Qian Gu Wei-Ping Zheng +2 位作者 Da-Hong Teng ji-san sun Hong Zheng 《World Journal of Gastroenterology》 SCIE CAS 2016年第9期2749-2759,共11页
Hepatocellular carcinoma (HCC) is the most common primary neoplasm of the liver and is one of the leading causes of cancer-related death worldwide. Liver transplantation (LT) has become one of the best curative therap... Hepatocellular carcinoma (HCC) is the most common primary neoplasm of the liver and is one of the leading causes of cancer-related death worldwide. Liver transplantation (LT) has become one of the best curative therapeutic options for patients with HCC, although tumor recurrence after LT is a major and unaddressed cause of mortality. Furthermore, the factors that are associated with recurrence are not fully understood, and most previous studies have focused on the biological properties of HCC, such as the number and size of the HCC nodules, the degree of differentiation, the presence of hepatic vascular invasion, elevated serum levels of alpha-fetoprotein, and the tumor stage outside of the Milan criteria. Thus, little attention has been given to factors that are not directly related to HCC (i.e., &#x0201c;non-oncological factors&#x0201d;), which have emerged as predictors of tumor recurrence. This review was performed to assess the effects of non-oncological factors on tumor recurrence after LT. The identification of these factors may provide new research directions and clinical strategies for the prophylaxis and surveillance of tumor recurrence after LT, which can help reduce recurrence and improve patient survival. 展开更多
关键词 Liver transplantation Immunosuppressive agents Hepatocellular carcinoma RECURRENCE Living donor Deceased donor
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