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EZH2、p16启动子在乳腺癌亚型中的表达及其与临床病理特征的关系 被引量:4
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作者 张一兵 胡继卫 +1 位作者 卢鹤翔 董桂兰 《中国现代医学杂志》 CAS 2018年第21期42-47,共6页
目的探讨EZH2与p16启动子甲基化与乳腺癌分子分型及临床病理参数的关系。方法 81例乳腺癌患者根据乳腺癌分子分型标准分组,采用免疫组织化学和甲基化特异性PCR(MSP)分别检测EZH2蛋白表达和p16启动子甲基化水平,并分析各组表达差异以及... 目的探讨EZH2与p16启动子甲基化与乳腺癌分子分型及临床病理参数的关系。方法 81例乳腺癌患者根据乳腺癌分子分型标准分组,采用免疫组织化学和甲基化特异性PCR(MSP)分别检测EZH2蛋白表达和p16启动子甲基化水平,并分析各组表达差异以及与临床病理的关系。结果 EZH2表达与组织分级、临床分期、淋巴结转移组和ER表达有关(P<0.05)。p16启动子甲基化与组织分级、临床分期有关(P<0.05)。在luminal A、luminal B、人表皮生长因子受体2(HER-2)过表达、三阴型(TNBC)组中EZH2的阳性表达率分别为36.3%(8/22)、36%(9/25)、60%(6/10)、70.8%(17/24),差异有统计学意义(P<0.05)。p16启动子甲基化率分别为27.2%(6/22)、28.0%(7/25)、40%(4/10)和54.2%(13/24),差异无统计学意义(P>0.05)。EZH2阳性表达组p16甲基化率高于EZH2阴性表达组,两者呈正相关(52.5%vs 21.9%,r=0.276,P=0.004)。结论EZH2与p16启动子甲基化与乳腺癌的发生发展密切相关,其中EZH2可作为乳腺癌尤其TNBC乳腺癌预后评估指标之一。 展开更多
关键词 乳腺肿瘤 EZH2 P16 甲基化 分子亚型
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Manufacturing enterprise collaboration network:An empirical research and evolutionary model
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作者 ji-wei hu Song Gao +2 位作者 Jun-Wei Yan Ping Lou Yong Yin 《Chinese Physics B》 SCIE EI CAS CSCD 2020年第8期553-563,共11页
With the increasingly fierce market competition,manufacturing enterprises have to continuously improve their competitiveness through their collaboration and labor division with each other,i.e.forming manufacturing ent... With the increasingly fierce market competition,manufacturing enterprises have to continuously improve their competitiveness through their collaboration and labor division with each other,i.e.forming manufacturing enterprise collaborative network(MECN)through their collaboration and labor division is an effective guarantee for obtaining competitive advantages.To explore the topology and evolutionary process of MECN,in this paper we investigate an empirical MECN from the viewpoint of complex network theory,and construct an evolutionary model to reproduce the topological properties found in the empirical network.Firstly,large-size empirical data related to the automotive industry are collected to construct an MECN.Topological analysis indicates that the MECN is not a scale-free network,but a small-world network with disassortativity.Small-world property indicates that the enterprises can respond quickly to the market,but disassortativity shows the risk spreading is fast and the coordinated operation is difficult.Then,an evolutionary model based on fitness preferential attachment and entropy-TOPSIS is proposed to capture the features of MECN.Besides,the evolutionary model is compared with a degree-based model in which only node degree is taken into consideration.The simulation results show the proposed evolutionary model can reproduce a number of critical topological properties of empirical MECN,while the degree-based model does not,which validates the effectiveness of the proposed evolutionary model. 展开更多
关键词 manufacturing enterprise collaboration network complex network topological properties fitness preferential attachment
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