To study the diverse coordination modes of the H_2btib,three new coordination architectures,namely, [Ag（Hbtib）CH_3CN]_n（1）,）[Ag（Hbtib）]_n（2） and[Pb（btib）（CH_3OH）_2]_n（3）（where H_2btib=4-（（2-butyl-5-...To study the diverse coordination modes of the H_2btib,three new coordination architectures,namely, [Ag（Hbtib）CH_3CN]_n（1）,）[Ag（Hbtib）]_n（2） and[Pb（btib）（CH_3OH）_2]_n（3）（where H_2btib=4-（（2-butyl-5-（2- carboxy-3-（thiophen-2-yl）prop-1-enyl）-1H-imidazol-1-yl）methyl）benzoic acid） have been synthesized and characterized by elemental analysis,IR spectrum and single-crystal X-ray diffraction.Complex 1 exhibits 1D single chain structure,while 2 shows 1D double metal chain motif,and 3 features a 2D layer topology.Also,1,2 and 3 display strong emission band in the solid state at room temperature.展开更多
In this study, novel mono/di-nuclear Cu（p-2-bmb）（OH）（Cl O4）（1） and Co2（p-2-bmb）2Cl4（2）（p-2-bmb = 1-（（2-（pyridin-2-yl）-benzoimidazol-1-yl）methyl）-1H-benzotriazole） complexes with the nitrogen hetero...In this study, novel mono/di-nuclear Cu（p-2-bmb）（OH）（Cl O4）（1） and Co2（p-2-bmb）2Cl4（2）（p-2-bmb = 1-（（2-（pyridin-2-yl）-benzoimidazol-1-yl）methyl）-1H-benzotriazole） complexes with the nitrogen heterocyclic benzimidazole-based ligand were synthesized and characterized. The two complexes showed antiproliferative effects in various carcinoma cell lines, especially complex 1 in the SMMC7721 tumor cell line. Complex 1 was also able to pass through the cell membrane and enter the nucleus and mitochondrion. An analysis of in vitro chemical nuclease activity revealed that complex 1 partially intercalated to calf thymus DNA and exhibited strong unwinding activity against p BR322 superhelical plasmid DNA. The comet assay and flow cytometry analysis confirmed that 1 caused extensive DNA damage and arrested SMMC7721 tumor cells at G2/M phase of the cell cycle, leading to loss of mitochondrial membrane potential and apoptosis. These results suggest that these benzimidazole-based metal complexes could be potential anti-cancer agents.展开更多
基金the financial support by the He'nan Key Science and Technology Research(Nos.112102310084 and 122102310061)
文摘To study the diverse coordination modes of the H_2btib,three new coordination architectures,namely, [Ag（Hbtib）CH_3CN]_n（1）,）[Ag（Hbtib）]_n（2） and[Pb（btib）（CH_3OH）_2]_n（3）（where H_2btib=4-（（2-butyl-5-（2- carboxy-3-（thiophen-2-yl）prop-1-enyl）-1H-imidazol-1-yl）methyl）benzoic acid） have been synthesized and characterized by elemental analysis,IR spectrum and single-crystal X-ray diffraction.Complex 1 exhibits 1D single chain structure,while 2 shows 1D double metal chain motif,and 3 features a 2D layer topology.Also,1,2 and 3 display strong emission band in the solid state at room temperature.
基金supported by the National Natural Science Foundation of China (Nos. 21371046, 21401041)
文摘In this study, novel mono/di-nuclear Cu（p-2-bmb）（OH）（Cl O4）（1） and Co2（p-2-bmb）2Cl4（2）（p-2-bmb = 1-（（2-（pyridin-2-yl）-benzoimidazol-1-yl）methyl）-1H-benzotriazole） complexes with the nitrogen heterocyclic benzimidazole-based ligand were synthesized and characterized. The two complexes showed antiproliferative effects in various carcinoma cell lines, especially complex 1 in the SMMC7721 tumor cell line. Complex 1 was also able to pass through the cell membrane and enter the nucleus and mitochondrion. An analysis of in vitro chemical nuclease activity revealed that complex 1 partially intercalated to calf thymus DNA and exhibited strong unwinding activity against p BR322 superhelical plasmid DNA. The comet assay and flow cytometry analysis confirmed that 1 caused extensive DNA damage and arrested SMMC7721 tumor cells at G2/M phase of the cell cycle, leading to loss of mitochondrial membrane potential and apoptosis. These results suggest that these benzimidazole-based metal complexes could be potential anti-cancer agents.
