Dear Editor,Immune-directed therapeutic approaches have changed the paradigm of cancer treatment.The tumor-immune microenvironment[1]is a dynamic milieu consisting of heterogeneous metabolic conditions such as low oxy...Dear Editor,Immune-directed therapeutic approaches have changed the paradigm of cancer treatment.The tumor-immune microenvironment[1]is a dynamic milieu consisting of heterogeneous metabolic conditions such as low oxygen,nutrient deficiency,acidity,and interactions between multiple cell types.In particular,immune cells in the tumor microenvironment are vulnerable to cellular dysfunctions(because of metabolic reprogramming[2])and engage in intercellular communications with neighboring cells.展开更多
基金This research was supported by a grant from the National Research Foundation,funded by the Ministry of Science and Information&Communication Technology,Republic of Korea(2018R1A5A2025079).
文摘Dear Editor,Immune-directed therapeutic approaches have changed the paradigm of cancer treatment.The tumor-immune microenvironment[1]is a dynamic milieu consisting of heterogeneous metabolic conditions such as low oxygen,nutrient deficiency,acidity,and interactions between multiple cell types.In particular,immune cells in the tumor microenvironment are vulnerable to cellular dysfunctions(because of metabolic reprogramming[2])and engage in intercellular communications with neighboring cells.
