Objective:To evaluate the anti-allergic effect of boeravinone B against ovalbumin-induced allergic rhinitis in mice and explore its possible mechanism.Methods:For the induction of allergic rhinitis,mice were intraperi...Objective:To evaluate the anti-allergic effect of boeravinone B against ovalbumin-induced allergic rhinitis in mice and explore its possible mechanism.Methods:For the induction of allergic rhinitis,mice were intraperitoneally sensitized and intranasally challenged with ovalbumin,as well as orally received various concentrations of boeravinone B.Nasal mucosal inflammation,and the levels of nitric oxide,β-hexosaminidase,IFN-γ,LTC-4,myeloperoxidase,Nrf2,HO-1,GATA-3,ROR-γ,T-bet,antioxidant parameters,and allergen-specific cytokines were assessed.Results:Boeravinone B markedly reduced ovalbumin-induced increase in the number of episodes of nasal sneezing,rubbing,and discharge,as well as the levels of IgE,IgG1,andβ-hexosaminidase(P<0.05).It also significantly reduced differential cell count,myeloperoxidase,oxide-nitrosative stress,and the levels of IL-1β,IL-4,IL-5,IL-6,IL-13,IL-17,tumor necrosis factor-α,GATA-3,and ROR-γwhile enhancing the level of T-bet.Conclusions:Boeravinone B is a potential therapeutic agent for allergic rhinitis by modulating various inflammatory mediators and immune responses.展开更多
Hydrogels are cross-linked polymers suitable for various applications,but the thermal conductivities of hydrogel-based composites have not been thoroughly investigated.In this study,agarose hydrogel-based composites w...Hydrogels are cross-linked polymers suitable for various applications,but the thermal conductivities of hydrogel-based composites have not been thoroughly investigated.In this study,agarose hydrogel-based composites with various boron nitride(BN)fillers were synthesized and their thermal conductivities were systematically investigated.With the increase in the agarose content from 1.5 wt%to 3.0 wt%,the thermal conductivity of the composite decreased.The composites with BN micropowder had larger thermal conductivities than those of the composites with BN nanopowder at the same filler loading,as the BN micropowder provided better thermal conduction pathways in the hydrogel matrix than those provided by the nanopowder.The maximum thermal conductivity of 2.69 W m-1·K-1 was achieved when 15 wt%microscale BN fillers were added into 1.5 wt%agarose hydrogel,which was 3.5 times larger than that of the pure agarose hydrogel.Additionally,a theoretical model was used to calculate the thermal conductivities of the BN/agarose hydrogel composites;a good agreement was achieved between the experimental and fitting ones.This study demonstrated that the thermal conductivities of hydrogel-based materials can be efficiently and significantly enhanced using BN fillers.展开更多
文摘Objective:To evaluate the anti-allergic effect of boeravinone B against ovalbumin-induced allergic rhinitis in mice and explore its possible mechanism.Methods:For the induction of allergic rhinitis,mice were intraperitoneally sensitized and intranasally challenged with ovalbumin,as well as orally received various concentrations of boeravinone B.Nasal mucosal inflammation,and the levels of nitric oxide,β-hexosaminidase,IFN-γ,LTC-4,myeloperoxidase,Nrf2,HO-1,GATA-3,ROR-γ,T-bet,antioxidant parameters,and allergen-specific cytokines were assessed.Results:Boeravinone B markedly reduced ovalbumin-induced increase in the number of episodes of nasal sneezing,rubbing,and discharge,as well as the levels of IgE,IgG1,andβ-hexosaminidase(P<0.05).It also significantly reduced differential cell count,myeloperoxidase,oxide-nitrosative stress,and the levels of IL-1β,IL-4,IL-5,IL-6,IL-13,IL-17,tumor necrosis factor-α,GATA-3,and ROR-γwhile enhancing the level of T-bet.Conclusions:Boeravinone B is a potential therapeutic agent for allergic rhinitis by modulating various inflammatory mediators and immune responses.
基金financially supported by the National Natural Science Foundation of China(No.51572149)Science and Technology on Advanced Ceramic Fibers and Composites Laboratory,Opening Project of Engineering Research Center of Nano-Geo Materials of Ministry of Education of China University of Geosciences(No.NGM2018KFO10)+1 种基金the National Key Research and Development Program of China(No.2016YFA0201003)the Fund of Key Laboratory of Advanced Materials of Ministry of Education(No.2017AML11)
文摘Hydrogels are cross-linked polymers suitable for various applications,but the thermal conductivities of hydrogel-based composites have not been thoroughly investigated.In this study,agarose hydrogel-based composites with various boron nitride(BN)fillers were synthesized and their thermal conductivities were systematically investigated.With the increase in the agarose content from 1.5 wt%to 3.0 wt%,the thermal conductivity of the composite decreased.The composites with BN micropowder had larger thermal conductivities than those of the composites with BN nanopowder at the same filler loading,as the BN micropowder provided better thermal conduction pathways in the hydrogel matrix than those provided by the nanopowder.The maximum thermal conductivity of 2.69 W m-1·K-1 was achieved when 15 wt%microscale BN fillers were added into 1.5 wt%agarose hydrogel,which was 3.5 times larger than that of the pure agarose hydrogel.Additionally,a theoretical model was used to calculate the thermal conductivities of the BN/agarose hydrogel composites;a good agreement was achieved between the experimental and fitting ones.This study demonstrated that the thermal conductivities of hydrogel-based materials can be efficiently and significantly enhanced using BN fillers.
