Increasing research suggests that cancer is a metabolic disease.During tumor development,cancer cells increase their biosynthetic and bioenergetic demands to maintain tumor cell proliferation and metastasis.The focus ...Increasing research suggests that cancer is a metabolic disease.During tumor development,cancer cells increase their biosynthetic and bioenergetic demands to maintain tumor cell proliferation and metastasis.The focus of research on this topic has been on the metabolism of the primary tumor,while metabolic adjustments during primary tumor growth/progression and metastatic processes have not been extensively investigated.The current evidence indicates that the metabolism during tumor development is dynamic.Moreover,emerging data suggest that,once the tumor cells leave their primary sites,they may show different metabolic features distinct from the primary tumor,enabling them to successfully survive and metastasize.In this review,we summarize how this metabolic flexibility occurs during the growth of the primary tumor and the metastatic process,and also explore how metabolic adaptation is influenced by the microenvironments of the tumor cells.We hope that this review will provide inspiration and guidance for future research on tumor metabolism.展开更多
文摘Increasing research suggests that cancer is a metabolic disease.During tumor development,cancer cells increase their biosynthetic and bioenergetic demands to maintain tumor cell proliferation and metastasis.The focus of research on this topic has been on the metabolism of the primary tumor,while metabolic adjustments during primary tumor growth/progression and metastatic processes have not been extensively investigated.The current evidence indicates that the metabolism during tumor development is dynamic.Moreover,emerging data suggest that,once the tumor cells leave their primary sites,they may show different metabolic features distinct from the primary tumor,enabling them to successfully survive and metastasize.In this review,we summarize how this metabolic flexibility occurs during the growth of the primary tumor and the metastatic process,and also explore how metabolic adaptation is influenced by the microenvironments of the tumor cells.We hope that this review will provide inspiration and guidance for future research on tumor metabolism.
