Cholesterol is a lipid that is an essential component of the membrane structure in mammals.Cholesterol homeostasis regulates vital activities of individual cells and governs the overall function of the mammalian body....Cholesterol is a lipid that is an essential component of the membrane structure in mammals.Cholesterol homeostasis regulates vital activities of individual cells and governs the overall function of the mammalian body.Cholesterol is mainly obtained through the biosynthesis of endogenous cholesterol and the intake of exogenous cholesterol.Cholesterol metabolism in tumor cells is abnormally active,and cholesterol and its metabolites(precursors and derivatives)play important roles in cancer proliferation,survival,invasion,metastasis,and the resistance to radiation.Preclinical studies have indicated that blocking cholesterol synthesis and uptake can reduce tumor progression and improve the response to anticancer treatment.Therapeutic strategies that target cholesterol synthesis,reduce plasma cholesterol levels,and prevent cholesterol esterification represent promising ways to improve the clinical outcome of cancer patients.展开更多
基金supported by grants from the Project of Sichuan Science and Technology Department(No.2021YJ0010)the Sichuan Natural Science Foundation(No.2023NSFC0712).
文摘Cholesterol is a lipid that is an essential component of the membrane structure in mammals.Cholesterol homeostasis regulates vital activities of individual cells and governs the overall function of the mammalian body.Cholesterol is mainly obtained through the biosynthesis of endogenous cholesterol and the intake of exogenous cholesterol.Cholesterol metabolism in tumor cells is abnormally active,and cholesterol and its metabolites(precursors and derivatives)play important roles in cancer proliferation,survival,invasion,metastasis,and the resistance to radiation.Preclinical studies have indicated that blocking cholesterol synthesis and uptake can reduce tumor progression and improve the response to anticancer treatment.Therapeutic strategies that target cholesterol synthesis,reduce plasma cholesterol levels,and prevent cholesterol esterification represent promising ways to improve the clinical outcome of cancer patients.
