Mitochondria are highly mobile organelles due to fission,fusion,transport,and mitophagy,and these processes are known as mitochondrial dynamics.Mitochondrial dynamics play an important role in energy production,cell d...Mitochondria are highly mobile organelles due to fission,fusion,transport,and mitophagy,and these processes are known as mitochondrial dynamics.Mitochondrial dynamics play an important role in energy production,cell division,cell differentiation,and cell death.In the past decade,numerous studies have revealed the importance of mitochondrial metabolism in immunity,and mitochondrial dynamics are essential for immune responses mediated by various cell types.In this review,we mainly discuss the role of mitochondrial dynamics in activation,differentiation,cytokine production,and the activity of related pathways in immune cells,particularly T cells,B cells,and other cells involved in the innate immune response.展开更多
基金This review was supported by the Excellent Young Scientist Foundation of NSFC(grant No.31822017)the Zhejiang Provincial Natural Science Foundation of China under grant no.LR19C080001+1 种基金the National Natural Science Foundation of China(grant nos.81572651 and 81771675)the Fundamental Research Funds for the Central Universities。
文摘Mitochondria are highly mobile organelles due to fission,fusion,transport,and mitophagy,and these processes are known as mitochondrial dynamics.Mitochondrial dynamics play an important role in energy production,cell division,cell differentiation,and cell death.In the past decade,numerous studies have revealed the importance of mitochondrial metabolism in immunity,and mitochondrial dynamics are essential for immune responses mediated by various cell types.In this review,we mainly discuss the role of mitochondrial dynamics in activation,differentiation,cytokine production,and the activity of related pathways in immune cells,particularly T cells,B cells,and other cells involved in the innate immune response.
