Mg_(17)Al_(12)(110)表面终端稳定性的密度泛函理论研究

Mg_(17)Al_(12)(110)面具有T1~T5共5个可能的终端结构。长期以来,T3一直被认为是该表面最稳定的终端,然而最近的理论计算表明T1终端可能更加稳定。为了解决这一争议,本文作者采用密度泛函理论计算揭示Mg_(17)Al_(12)(110)面最稳定的终端形式。表面能计算结果表明,不论Mg_(17)Al_(12)(110)面是否存在缺陷,T1总是该面最稳定的终端。T1终端的高稳定性可能与Mg_(17)Al_(12)中的Al截角四面体有关,因为只有沿着T1终端截取Mg_(17)Al_(12)(110)面才不会破坏Al截角四面体的完整性。除了揭示最稳定的终端,还计算了Mg_(17)Al_(12)(110)面的功函数,结果表明该面的功函数主要由表面的AlMg缺陷浓度决定。

不同分层体系结构钨酸铋对可见光催化降解诺氟沙星的影响（英文）

研究不同分层体系结构钨酸铋对可见光催化降解诺氟沙星的影响。在pH值为4~11条件下采用水热法反应合成钨酸铋。结果表明:在pH值为4条件下制备的钨酸铋对诺氟沙星具有很好的吸附和光催化性能。表征结果显示,pH值为4时制备的钨酸铋具有较大的比表面积和光生载流子分离效率。在弱碱条件下,催化降解速率达到最大,这是由于弱碱溶液提供了足量的OH^-,光子与材料表面吸附的OH^-反应生成了羟基自由基。本实验证明,较小尺寸的超薄钨酸铋是一种有效的诺氟星沙污染水体光催化剂。

The Short-term Effects of Temperature on Infectious Diarrhea among Children under 5 Years Old in Jiangsu,China:A Time-series Study(2015-2019)

The association between meteorological factors and infectious diarrhea has been widely studied in many countries.However,investigation among children under 5 years old in Jiangsu,China remains quite limited.Data including infectious diarrhea cases among children under five years old and daily meteorological indexes in Jiangsu,China from 2015 to 2019 were collected.The lag-effects up to 21 days of daily maximum temperature(Tmax)on infectious diarrhea were explored using a quasi-Poisson regression with a distributed lag non-linear model(DLNM)approach.The cases number of infectious diarrhea was significantly associated with seasonal variation of meteorological factors,and the burden of disease mainly occurred among children aged 0-2 years old.Moreover,when the reference value was set at 16.7°C,Tmax had a significant lag-effect on cases of infectious diarrhea among children under 5 years old in Jiangsu Province,which was increased remarkably in cold weather with the highest risk at 8℃.The results of DLNM analysis implicated that the lag-effect of Tmax varied among the 13 cities in Jiangsu and had significant differences in 8 cities.The highest risk of Tmax was presented at 5 lag days in Huaian with a maximum RR of 1.18(95% CI:1.09,1.29).Suzhou which had the highest number of diarrhea cases(15830 cases),had a maximum RR of 1.04(95%CI:1.03,1.05)on lag 15 days.Tmax is a considerable indicator to predict the epidemic of infectious diarrhea among 13 cities in Jiangsu,which reminds us that in cold seasons,more preventive strategies and measures should be done to prevent infectious diarrhea.

Short photoperiod increases energy intake, metabolic thermogenesis and organ mass in silky starlings Sturnus sericeus

Environmental cues play important roles in the regulation of an animal＇s physiology and behavior. One such cue, photoperiod, plays an important role in the seasonal acclimatization of birds. It has been demonstrated that an animal＇s body mass, basal metabolic rate （BMR）, and energy intake, are all affected by photoperiod. The present study was designed to examine photoperiod induced changes in the body mass, metabolism and metabolic organs of the silky starling, Stumus sericeus. Captive silky starlings increased their body mass and BMR during four weeks of acclimation to a short photoperiod. Birds acclimated to a short photopedod also increased the mass of certain organs （liver, gizzard and small intestine）, and both gross energy intake （GEl） and digestible energy intake （DEI）, relative to those acclimated to a long photoperiod. Furthermore, BMR was positively correlated with body mass, liver mass, GEl and DEI. These results suggest that silky starlings increase metabolic thermogenesis when exposed to a short photoperiod by increasing their body and metabolic organ mass, and their GEl and DEI. These findings support the hypothesis that bird species from temperate climates typically display high phenotypic flexibility in thermogenic capacity.

艾灸对轻度认知障碍患者认知注意网络功能的影响

Objective:To explore the effect differences between moxibustion and donepezil hydrochloride on the attention network function of patients with mild cognitive impairment(MCI).Methods:A total of 64 patients of MCI were randomly divided into the moxibustion group and donepezil hydrochloride group,32 cases in each one.On the basis of conventional treatment,the patients in the moxibustion group were given moxibustion,6 times a week,and the patients in the donepezil hydrochloride group were given donepezil hydrochloride orally,5 mg/day.The course of treatment was 60 days for both of the groups.Cognitive attention network function and activities of daily living(ADL)score were examined before and after treatment.Results:The differences of alerting reaction time(RT),executive control RT,overall mean RT and accuracy of the moxibustion group after treatment were significantly higher than those of the donepezil hydrochloride group[alert:(60.3±3.3)ms vs(48.3±3.7)ms,P<0.05;executive control:(81.2±3.2)ms vs(91.7±4.2)ms,P<0.05;total reaction time:(500.4±17.2)ms vs(536.2±20.1)ms.P<0.05;accuracy:(83.7±4.6)%vs(77.4±4.3)%,P<0.05].After treatment,the ADL scores of the both groups were significantly higher than those before treatment[the moxibustion group:(56.47±4.02)points vs(41.53±4.06)points,P<0.05;the donepezil hydrochloride group:(50.75±4.05)points vs(40.84±3.67)points,P<0.05],and the ADL score of the moxibustion group was significantly higher than that of the donepezil hydrochloride group[(56.47±4.02)points vs(50.75±4.05)points,P<0.05].Conclusion:Compared with donepezil hydrochloride,moxibustion has a better effect on the cognitive function of MCI patients.

SYNTHESIS AND CHARACTERISTICS OF A CHELATING RESIN AS AN EXTRACTANT AND CHROMOGENIC REAGENT OF HEAVY METAL IONS IN SOLID PHASE EXTRACTION

A new chelating resin （CPS-DMA-SABA） was synthesized with the chloromethylated crossqinked polystyrene porous beads （CPS） as raw materials, which were bonded with salicylidene-o-aminobenzoic acid （SABA） on the surface via a quaternary ammonium unit as a linker. The results showed that CPS-DMA-SABA would easily change into a zwitterionic chelating resin （CPS-DMA-SABZ） when washed with distilled water. CPS-DMA-SABA was characterized by elemental analysis, infrared spectra and thermo-gravimetric analysis. The ion sorption capacities of CPS-DMA-SABA were found to be 1916 μg/g for Zn2＋ withpH at 4.5, 1620μg/g for Cu2＋ with pH at 6.2, 1291 μg/g for Ni2＋ withpH at 6.6 and 780 μg/g for Cr3＋ withpH at 5.5, respectively. The experiments showed CPS-DMA-SABA also changed its color when meeting with the metal ion in the aqueous solution. As a consequence, CPS-DMA-SABA can not only be used as a solid phase extractant but also an indicator for confirming the heavy metal ion in solutions.

Monocyte chemotactic protein-inducing protein 1 negatively regulating asthmatic airway inflammation and mucus hypersecretion involvingγ-aminobutyric acid type A receptor signaling pathway in vivo and in vitro

Background:Mounting evidence,consistent with our previous study,showed thatγ-aminobutyric acid type A receptor(GABAAR)played an indispensable role in airway inflammation and mucus hypersecretion in asthma.Monocyte chemotactic protein-inducing protein 1(MCPIP1)was a key negative regulator of inflammation.Recent studies showed that inflammation was largely suppressed by enhanced MCPIP1 expression in many inflammatory diseases.However,the role and potential mechanism of MCPIP1 in airway inflammation and mucus hypersecretion in asthma were still not well studied.This study was to explore the role of MCPIP1 in asthmatic airway inflammation and mucus hypersecretion in both mice and BEAS-2B cells,and its potential mechanism.Methods:In vivo,mice were sensitized and challenged by ovalbumin(OVA)to induce asthma.Airway inflammation and mucus secretion were analyzed.In vitro,BEAS-2B cells were chosen.Interleukin(IL)-13 was used to stimulate inflammation and mucus hypersecretion in cells.MCPIP1 Lentiviral vector(LA-MCPIP1)and plasmid-MCPIP1 were used to up-regulate MCPIP1 in lung and cells,respectively.MCP-1,thymic stromal lymphopoietin(TSLP),mucin 5AC(MUC5AC),MCPIP1,and GABAARβ2 expressions were measured in both lung and BEAS-2B cells.Immunofluorescence staining was performed to observe the expression of GABAARβ2 in cells.Results:MCPIP1 was up-regulated by LA-MCPIP1(P<0.001)and plasmid-MCPIP1(P<0.001)in lung and cells,respectively.OVA-induced airway inflammation and mucus hypersecretion,OVA-enhanced MCP-1,TSLP,MUC5AC,and GABAARβ2 expressions,and OVA-reduced MCPIP1 were significantly blunted by LA-MCPIP1 in mice(all P<0.001).IL-13-enhanced MCP-1,TSLP,MUC5AC,and GABAARβ2 expressions,and IL-13-reduced MCPIP1 were markedly abrogated by plasmid-MCPIP1 in BEAS-2B cells(all P<0.001).Conclusion:The results of this study suggested that OVA and IL-13-induced airway inflammation and mucus hypersecretion were negatively regulated by MCPIP1 in both lung and BEAS-2B cells,involving GABAAR signaling pathway.

柔性纤维生物电子复合材料与器件

可穿戴和可植入的纤维生物电子器件可以实现对人体生理体征的实时监测和精准调控,在健康监测和疾病诊疗等领域发挥了革新作用.然而,传统的纤维生物电子器件柔性不足而与生物软组织的力学性能不匹配,难以形成稳定的器件/组织界面,最终无法实现长期稳定工作.本文重点介绍了近年来课题组针对上述问题在柔性纤维生物电子复合材料与器件方面的研究进展.首先制备了具有杂化结构和芯鞘结构的柔性高分子复合纤维电极,并面向柔性生物电子器件要求,对纤维材料的电学和力学性能及生物安全性进行表征.进一步,基于所制备的复合纤维电极,发展出一系列可穿戴和可植入的纤维生物电子器件,具有传感、能源、调控等功能,并通过建立稳定的器件/组织界面,实现了在体长期工作,在生物医学研究和智慧医疗等领域展现出良好的应用前景.最后,展望了柔性纤维生物电子领域的未来发展方向.

Hyperterpenoids A and B:Two pairs of unprecedented 6/6/4/6/6 polycyclic cyclobutane meroterpenoids with potent neuroprotective and anti-inflammatory activities from Hypericum beanii

Hyperterpenoid A(1)and B(2),two pairs of enantiomers,with an unprecedented 6/6/4/6/6 polycyclic skeleton,along with one known compoud hypermonone A(3)were isolated from Hypericum beanii.The racemate(±)-1 and(±)-2 were successfully separated into the two optically pure enantiomers(ee>99%)using a preparative HPLC system.Their absolute configurations were elucidated by extensive spectroscopic analyses and single-crystal X-ray diffraction method.The related plausible biogenetic pathways were pre sented.Compound 1-3 showed significant neuroprotective activity and potential antiinflammatory activity.The result that(+)-2 and(-)-2 presented different anti-inflammatory properties,may lead us to new discovery of structure activity relationship between racemates,enantiomers,and diastereomers,as well as further research regarding the binding of drugs to target proteins.

Creep prediction model for nickel-based single-crystal superalloys considering precipitation of TCP phase

The microstructure of nickel-based single-crystal(SC) superalloys has a pivotal influence on their creep properties. The addition of the Re element not only enhances the long-term creep properties of nickel-based SC superalloys, but also results in the formation of a topologically close-packed(TCP) phase which is a harmful and brittle hard phase. Here, high-temperature creep interruption tests of a nickel-based SC superalloy that contains4.8 wt% Re were performed under various temperatures and stress conditions, and the evolution of microstructure during creep was observed by scanning electron microscopy(SEM). The volume fraction of the TCP phase was also extracted to explore the mechanism that controls the impacts of the TCP phase on the creep properties.According to the microstructure evolution mechanism, the influence of the TCP phase was attributed to the initial damage and critical shear stress of the material. A creep performance prediction model for nickel-based SC superalloys considering the precipitation of the TCP phase that is based on the crystal plasticity theory and a modified creep damage model was established. The simulation curves fit well with the experimental results and the errors between prediction creep life with test results are within 5%.

Ramsay Hunt Syndrome in a Patient with H7N9 Influenza Virus Infection

To the Editor： We would like to present Ramsay Hunt syndrome （RHS） as a complication of H7N9 influenza virus infection. On January 22, 2014, a 57-year-old man with a history of rheumatoid arthritis was admitted to the hospital complaining of dyspnea and fever. Infection with influenza A （H7N9） virus was confirmed from a tracheal aspirate sample using polymerase chain reaction （PCR） assays. Hypoxemia led to non-invasive mechanical ventilation on the first day. Methylprednisolone （80 mg intravenous every 24 hours） and oseltamivir were administered starting from the first day. On day 11, otalgia and secretion of yellow exudate was associated with a swollen right external auditory canal. Four days later, a vesicular rash developed at the right earcanal and pinna. Symptoms progressed over the following 48 hours in which right facial palsy, dysphagia, hoarseness, hearing loss, and vertigo were all present in the patient [Figure 1 ].

A Cost-Sharing Scheme for the k-Level Facility Location Game with Penalties

In the k-level facility location problem with penalties,each client will be either serviced or rejected completely.And if the client is planned to be serviced,then it must be connected to a sequence of k different kinds of facilities located in k levels of hierarchy.The total cost including the facility cost,connection cost and penalty cost will be jointly paid by all the clients.In the corresponding game of the k-level facility location problem with penalties,called the k-level facility location game with penalties,the total cost should be allocated to different clients.This work set out a cost-sharing scheme for the k-level facility location game with penalties that is cross-monotonic,competitive,and the approximate cost recovery is 6.