Objective:To study the TLRs family expression in lesions and peripheral blood of patients with acne and their regulating effect on the synthesis of inflammatory mediators.Methods:A total of 60 patients with acne vulga...Objective:To study the TLRs family expression in lesions and peripheral blood of patients with acne and their regulating effect on the synthesis of inflammatory mediators.Methods:A total of 60 patients with acne vulgaris who were treated in our hospital between June 2013 and July 2016 were selected as the acne group, and 48 patients with trauma who accepted debridement and suturing in our hospital during the same period were selected as the control group. The acne focus tissue and the skin tissue after debridement were collected to determine the expression of TLRs and inflammatory mediators, and the peripheral blood mononuclear cells were collected to determine the expression of TLRs.Results:TLR2 and TLR4 protein expression in skin tissue and peripheral blood mononuclear cells of acne group were significantly higher than those of control group while the TLR3, TLR5, TLR7 and TLR9 protein expression were not significantly different from those of control group;IL-1 , IL-1β, IL-8 and TNF-α levels in acne tissue with high TLR2 and TLR4 expression were significantly higher than those in acne tissue with low TLR2 and TLR4 expression.Conclusion: TLR2 and TLR4 are highly expressed in lesions and peripheral blood of patients with acne and have promoting effect on the synthesis of inflammatory mediators.展开更多
文摘Objective:To study the TLRs family expression in lesions and peripheral blood of patients with acne and their regulating effect on the synthesis of inflammatory mediators.Methods:A total of 60 patients with acne vulgaris who were treated in our hospital between June 2013 and July 2016 were selected as the acne group, and 48 patients with trauma who accepted debridement and suturing in our hospital during the same period were selected as the control group. The acne focus tissue and the skin tissue after debridement were collected to determine the expression of TLRs and inflammatory mediators, and the peripheral blood mononuclear cells were collected to determine the expression of TLRs.Results:TLR2 and TLR4 protein expression in skin tissue and peripheral blood mononuclear cells of acne group were significantly higher than those of control group while the TLR3, TLR5, TLR7 and TLR9 protein expression were not significantly different from those of control group;IL-1 , IL-1β, IL-8 and TNF-α levels in acne tissue with high TLR2 and TLR4 expression were significantly higher than those in acne tissue with low TLR2 and TLR4 expression.Conclusion: TLR2 and TLR4 are highly expressed in lesions and peripheral blood of patients with acne and have promoting effect on the synthesis of inflammatory mediators.
