Background: Rhizoma drynariae is a traditional Chinese medicine used in orthopedics and traumatology, but its effect on endometrial receptivity remains unknown. Aims and Objectives: To observe effect of Rhizoma drynar...Background: Rhizoma drynariae is a traditional Chinese medicine used in orthopedics and traumatology, but its effect on endometrial receptivity remains unknown. Aims and Objectives: To observe effect of Rhizoma drynariae and its main components on endometrial receptivity in a mus model of dysfunctional embryo implantation. Materials and Methods: Mus models were established by the Gn RHa+HMG+HCG method. Normal mus receiving saline were used as controls and the remaining six groups were: model receiving saline, progynova, aspirin, Rhizoma drynariae, osteopractic total flavone, and naringin. Pinopodes in uterine endometrium were examined by scanning electron microscopy. Stem cell factor(SCF) m RNA expressions was determined by real-time RT-PCR, and estrogen receptor α(ERα), progesterone receptor(PR) by immunohistochemistry. Results: In the model group, surface morphology of endometrium was heterogeneous, without obvious pinopodes. In the Rhizoma drynaria and progynova groups, pinopodes were abundant. Compared with the blank group, model group had lower levels of SCF(-47%), ERα(-63%) and PR(-50%)(all P<0.05). In comparison, Rhizoma drynariae group had higher levels of SCF(+73%), ERα(+118%) and PR(+101%)(all P<0.01). The individual main components of Rhizoma drynariae had variable efficacy. Conclusion: Rhizoma drynariae could improve endometrial receptivity of mouse models of dysfunctional embryo implantation as shown by increased numbers of pinopodes and higher levers of SCF, ERα, PR compared with the model group.展开更多
The GH4169 superalloy with different content ofδ-Ni3Nb phase was welded by tungsten inert gas welding.A detailed study of microstructure and hardness of heat-affected zone(HAZ)was performed in both as-welded and aged...The GH4169 superalloy with different content ofδ-Ni3Nb phase was welded by tungsten inert gas welding.A detailed study of microstructure and hardness of heat-affected zone(HAZ)was performed in both as-welded and aged state.The results show that the precipitation ofδphase,especially the intergranularδphase,can lead to the enrichment of Nb and Mo elements,which promote the formation ofγ/Laves eutectic constituent at grain boundaries in HAZ.In as-welded state,the hardness decreases first and then increases(exhibiting a"V"shape)with distance away from fusion line in HAZ,which is governed by grain size.After aging treatment,however,theγ″phase plays a key role in hardness and leads to the"■"shape profiles of hardness in HAZ.展开更多
基金funded by the National Natural Science Foundation of China(81473721,81273789)。
文摘Background: Rhizoma drynariae is a traditional Chinese medicine used in orthopedics and traumatology, but its effect on endometrial receptivity remains unknown. Aims and Objectives: To observe effect of Rhizoma drynariae and its main components on endometrial receptivity in a mus model of dysfunctional embryo implantation. Materials and Methods: Mus models were established by the Gn RHa+HMG+HCG method. Normal mus receiving saline were used as controls and the remaining six groups were: model receiving saline, progynova, aspirin, Rhizoma drynariae, osteopractic total flavone, and naringin. Pinopodes in uterine endometrium were examined by scanning electron microscopy. Stem cell factor(SCF) m RNA expressions was determined by real-time RT-PCR, and estrogen receptor α(ERα), progesterone receptor(PR) by immunohistochemistry. Results: In the model group, surface morphology of endometrium was heterogeneous, without obvious pinopodes. In the Rhizoma drynaria and progynova groups, pinopodes were abundant. Compared with the blank group, model group had lower levels of SCF(-47%), ERα(-63%) and PR(-50%)(all P<0.05). In comparison, Rhizoma drynariae group had higher levels of SCF(+73%), ERα(+118%) and PR(+101%)(all P<0.01). The individual main components of Rhizoma drynariae had variable efficacy. Conclusion: Rhizoma drynariae could improve endometrial receptivity of mouse models of dysfunctional embryo implantation as shown by increased numbers of pinopodes and higher levers of SCF, ERα, PR compared with the model group.
基金financially supported by the National Natural Science Foundation of China (No.51774213)the Regional Demonstration Project of Marine Economic Innovation and Development (No.BHSF2017-10)
文摘The GH4169 superalloy with different content ofδ-Ni3Nb phase was welded by tungsten inert gas welding.A detailed study of microstructure and hardness of heat-affected zone(HAZ)was performed in both as-welded and aged state.The results show that the precipitation ofδphase,especially the intergranularδphase,can lead to the enrichment of Nb and Mo elements,which promote the formation ofγ/Laves eutectic constituent at grain boundaries in HAZ.In as-welded state,the hardness decreases first and then increases(exhibiting a"V"shape)with distance away from fusion line in HAZ,which is governed by grain size.After aging treatment,however,theγ″phase plays a key role in hardness and leads to the"■"shape profiles of hardness in HAZ.
