Intra-abdominal inflammatory pseudotumor-like follicular dendritic cell sarcoma associated with paraneoplastic pemphigus: A case report and review of the literature

BACKGROUD Follicular dendritic cell(FDC)sarcomas are rare neoplasms that occur predominantly in the lymph nodes.They can also occur extranodally.Extranodal FDC sarcomas most commonly present as solitary masses.Inflammatory pseudotumor(IPT)-like FDC sarcomas,a subcategory of FDC sarcomas,are rarer than other sarcoma subtypes.They are composed of spindle or ovoid neoplastic cells and exhibit an admixture of plasma cells and prominent lymphoplasmacytic infiltration.Paraneoplastic pemphigus(PNP),also known as paraneoplastic autoimmune multiorgan syndrome,is a rare autoimmune bullous disease that is associated with underlying neoplasms.PNP has a high mortality,and its early diagnosis is usually difficult.CASE SUMMARY We describe a 27-year-old woman who presented with stomatitis,conjunctivitis,and skin blisters and erosions as her first symptoms of PNP with an intraabdominal IPT-like FDC sarcoma.The patient underwent surgical tumor resection and received tapering oral corticosteroid treatment.She showed no recurrence at the 1-year follow-up.CONCLUSION IPT-like FDC sarcomas are rare underlying neoplasms that have an uncommon association with PNP.PNP-associated FDC sarcomas predominantly occur in intra-abdominal sites and suggest a poor prognosis.Surgical resection is an essential and effective treatment for PNP and primary and recurrent FDC sarcomas.

Highly two-photon and X-ray excited long-persistent luminescence in a crystalline host-guest aggregate

As a unique type of supramolecular self-assemblies,crystalline host-guest aggregates have attracted extensive interests in multiple application fields.Herein,a crystalline host-guest aggregate LIFM-HG1 was obtained with curcubit[8]uril as the host and carboxypyridinium salt as the guest.Single-crystal structural analysis indicates that the presence of abundant weak interactions in LIFM-HG1 provides a rigid environment for the guest molecule and effectively blocks the external quenchers.Spectral analysis and theoretical calculations confirm the presence of robust triplet energy levels in LIFM-HG1.Even more impressively,the intersystem crossing channels of the guest molecules are greatly opened up after the formation of the crystalline host-guest aggregate,resulting in a large k_(isc)of 6.70×10^(7)s^(−1)at room temperature for LIFM-HG1(which is∼0 for pure guest),leading to fascinatingmultichannel(including one-photon,two-photon,and X-ray)excited LPL properties.In addition,the crystalline LIFM-HG1 has a much higher triplet state luminescence efficiency under X-ray and two-photon excitation than that under single-photon excitation(A_(P)/A_(F)=86.8,44.8,10.7 under the three circumstances,respectively).And the phosphorescent emission intensity of LIFM-HG1 is 27.6 times higher than that of the crystalline guest under X-ray excitation.As a result,LIFM-HG1 shows a long afterglow retention time under both single-and two-photon excitation,and an impressive afterglow retention time of 1 s under X-ray excitation.Furthermore,the excellent lysosomal targeting and low cytotoxicity by the formation of host-guest aggregate makes LIFM-HG1 promising to be used as a novel lysosomal-targeted two-photon excited phosphorescent tracer.