Comparison of evaluation indexes for Gastroenterology and Hepatology journals in different databases

BACKGROUND Accurate assessment of the quality of academic journals is of great significance.While Journal Impact Factor(JIF),calculated by Clarivate and based upon the Web of Science literature database,and CiteScore(CS),developed by Elseiver and based upon the Scopus database,have enjoyed high uptake worldwide,efforts continue towards creation of other scientometric indexes that will provide evergreater qualitative insights into journal impact.Such efforts have yielded the newly-launched Journal Article Influence Index(JAII),which is based on the Reference Citation Analysis(RCA)database,an open multidisciplinary citation analysis database based on artificial intelligence technology.AIM To evaluate and summarize the similarities and differences between JAII and JIF/CS as journal evaluation indicators,and provide an intuitive method for visual representation of the related data.METHODS We searched the Journal Citation Reports to obtain the 2021 JIF list,downloaded the CS list updated in July on the Scopus website,and collected the comprehensive list of 2022 JAIIs from the RCA database(www.referencecitationanalysis.com).RESULTS Our research results revealed that by breaking through the time limit of mainstream journalevaluation methods, the JAII is able to perform well in data reliability, establishing its benefit as acomplementary scientometric index to JIF and CS.CONCLUSIONJAII provides comprehensive assessment of the quality and performance of journals.

Exploration of Bioactive Constituents and Immunoregulatory Mechanisms of a Hanshi-Yufei Formulation for Treating COVID-19

Objective:The objective of this study was to characterize the chemical compounds of a Hanshi-Yufei formulation(HSYF;a modified formulation of a traditional Chinese medicine used for treating COVID-19)to elucidate the mechanism of action and to evaluate potential anti-inflammatory effects of HSYF.Materials and Methods:The chemical constituents of HSYF extract were characterized using UPLC-Q-TOF/MS.Subsequently,a set of TCM network pharmacology methods was applied to identify disease-associated genes and to predict target profiles and pharmacological actions associated with the constituents of HSYF.Then,the antiviral effects of HSYF on H1N1 were assessed in RAW264.7 cells using MTT assays.Expression levels of pro-inflammatory cytokines interleukin(IL)-6 and tumor necrosis factor(TNF)-αfollowing infection of RAW264.7 cells with H1N1 were measured using an enzyme-linked immune sorbent assay(ELISA),and expression levels of inflammatory-related factors were detected using western blotting.Results:In total,165 chemical constituents(including glycosides,tannins,volatile oils,amino acids,triterpenoids,polyphenols,phenylpropanoids,sesquiterpenes,alkaloids,and flavonoids,among others)were tentatively identified in HSYF.Network pharmacology demonstrated that HSYF can regulate immunomodulatory-and anti-inflammatory-related targets of multiple pathways through its active ingredients,suggesting potential anti-COVID-19 effects.Furthermore,cell viability assays and ELISA showed that HSYF significantly inhibited H1N1 replication in RAW64.7 cells and markedly reduced expression of pro-inflammatory cytokines TNF-αand IL-6 at the proteins level.Conclusions:The results of the present study help improve our understanding of the therapeutic effects of HSYF in COVID-19 treatment from multi-level perspectives.