BACKGROUND Peripherally inserted central catheters(PICCs)are commonly used in hospitalized patients with liver cancer for the administration of chemotherapy,nutrition,and other medications.However,PICC-related thrombo...BACKGROUND Peripherally inserted central catheters(PICCs)are commonly used in hospitalized patients with liver cancer for the administration of chemotherapy,nutrition,and other medications.However,PICC-related thrombosis is a serious complication that can lead to morbidity and mortality in this patient population.Several risk factors have been identified for the development of PICC-related thrombosis,including cancer type,stage,comorbidities,and catheter characteristics.Understanding these risk factors and developing a predictive model can help healthcare providers identify high-risk patients and implement preventive measures to reduce the incidence of thrombosis.AIM To analyze the influencing factors of PICC-related thrombosis in hospitalized patients with liver cancer,construct a predictive model,and validate it.METHODS Clinical data of hospitalized patients with liver cancer admitted from January 2020 to December 2023 were collected.Thirty-five cases of PICC-related thrombosis in hospitalized patients with liver cancer were collected,and 220 patients who underwent PICC placement during the same period but did not develop PICC-related thrombosis were randomly selected as controls.A total of 255 samples were collected and used as the training set,and 77 cases were collected as the validation set in a 7:3 ratio.General patient information,case data,catheterization data,coagulation indicators,and Autar Thrombosis Risk Assessment Scale scores were analyzed.Univariate and multivariate unconditional logistic regression analyses were performed on relevant factors,and the value of combined indicators in predicting PICC-related thrombosis in hospitalized patients with liver cancer was evaluated using receiver operating characteristic(ROC)curve analysis.RESULTS Univariate analysis showed statistically significant differences(P<0.05)in age,sex,Karnofsky performance status score(KPS),bedridden time,activities of daily living impairment,parenteral nutrition,catheter duration,distant metastasis,and bone marrow suppression between the thrombosis group and the non-thrombosis group.Other aspects had no statistically significant differences(P>0.05).Multivariate regression analysis showed that age≥60 years,KPS score≤50 points,parenteral nutrition,stage III to IV,distant metastasis,bone marrow suppression,and activities of daily living impairment were independent risk factors for PICC-related thrombosis in hospitalized patients with liver cancer(P<0.05).Catheter duration of 1-6 months and catheter duration>6 months were protective factors for PICC-related thrombosis(P<0.05).The predictive model for PICC-related thrombosis was obtained as follows:P predictive probability=[exp(Logit P)]/[1+exp(Logit P)],where Logit P=age×1.907+KPS score×2.045+parenteral nutrition×9.467+catheter duration×0.506+tumor-node-metastasis(TNM)staging×2.844+distant metastasis×2.065+bone marrow suppression×2.082+activities of daily living impairment×13.926.ROC curve analysis showed an area under the curve(AUC)of 0.827(95%CI:0.724-0.929,P<0.001),with a corresponding optimal cut-off value of 0.612,sensitivity of 0.755,and specificity of 0.857.Calibration curve analysis showed good consistency between the predicted occurrence of PICC-related thrombosis and actual occurrence(P>0.05).ROC analysis showed AUCs of 0.888 and 0.729 for the training and validation sets,respectively.CONCLUSION Age,KPS score,parenteral nutrition,TNM staging,distant metastasis,bone marrow suppression,and activities of daily living impairment are independent risk factors for PICC-related thrombosis in hospitalized patients with liver cancer,while catheter duration is a protective factor for the disease.The predictive model has an AUC of 0.827,indicating high predictive accuracy and clinical value.展开更多
Electromagnetic railgun attracts more and more attention due to its advantage in speed,cost,and obscurity.It is found that the rail should withstand huge mechanical and thermal shocks during the launching operation.Th...Electromagnetic railgun attracts more and more attention due to its advantage in speed,cost,and obscurity.It is found that the rail should withstand huge mechanical and thermal shocks during the launching operation.The forms of rail failure are accompanied by gouge,grooving,transition,and arc ablation,etc.The service life of the rail has become a bottleneck restricting the development of electromagnetic railgun technology.A series of researches are carried out to solve rail failure,including analysing the failure mechanism and using various advanced rail materials.This paper provides a comprehensive review of rail materials,including material composition,preparation,microstructure,and properties.We begin from a short background of the requirement of the rail material.Then a detailed investigation of rail materials is described,and the performances of those materials are introduced.Finally,further development prospect of rail material is discussed.展开更多
This paper presents an analytical model to solve the linear wave diffraction problem by arrays of bottom-mounted cylinders with arbitrary smooth cross-section.Based on the assumption of ideal fluid and potential theor...This paper presents an analytical model to solve the linear wave diffraction problem by arrays of bottom-mounted cylinders with arbitrary smooth cross-section.Based on the assumption of ideal fluid and potential theory,the unknown coefficients of total velocity potential can be solved by system of linear equations,which are obtained from the boundary conditions.The accuracy of the present method is verified by comparing it with the numerical tool in terms of the wave force and wave mn-up.Multiple cylinders with different configurations are tested,the cross-section of which is circular with cosine perturbation.The results show that the proposed method could obtain an accurate prediction of the wave action with multiple cylinder problems.Finally,the diffraction wave is investigated on arrays of bottom-mounted cylinders with different cross-section and layout.The near-trapping problem with effects of the multi-body interaction are also investigated.展开更多
文摘BACKGROUND Peripherally inserted central catheters(PICCs)are commonly used in hospitalized patients with liver cancer for the administration of chemotherapy,nutrition,and other medications.However,PICC-related thrombosis is a serious complication that can lead to morbidity and mortality in this patient population.Several risk factors have been identified for the development of PICC-related thrombosis,including cancer type,stage,comorbidities,and catheter characteristics.Understanding these risk factors and developing a predictive model can help healthcare providers identify high-risk patients and implement preventive measures to reduce the incidence of thrombosis.AIM To analyze the influencing factors of PICC-related thrombosis in hospitalized patients with liver cancer,construct a predictive model,and validate it.METHODS Clinical data of hospitalized patients with liver cancer admitted from January 2020 to December 2023 were collected.Thirty-five cases of PICC-related thrombosis in hospitalized patients with liver cancer were collected,and 220 patients who underwent PICC placement during the same period but did not develop PICC-related thrombosis were randomly selected as controls.A total of 255 samples were collected and used as the training set,and 77 cases were collected as the validation set in a 7:3 ratio.General patient information,case data,catheterization data,coagulation indicators,and Autar Thrombosis Risk Assessment Scale scores were analyzed.Univariate and multivariate unconditional logistic regression analyses were performed on relevant factors,and the value of combined indicators in predicting PICC-related thrombosis in hospitalized patients with liver cancer was evaluated using receiver operating characteristic(ROC)curve analysis.RESULTS Univariate analysis showed statistically significant differences(P<0.05)in age,sex,Karnofsky performance status score(KPS),bedridden time,activities of daily living impairment,parenteral nutrition,catheter duration,distant metastasis,and bone marrow suppression between the thrombosis group and the non-thrombosis group.Other aspects had no statistically significant differences(P>0.05).Multivariate regression analysis showed that age≥60 years,KPS score≤50 points,parenteral nutrition,stage III to IV,distant metastasis,bone marrow suppression,and activities of daily living impairment were independent risk factors for PICC-related thrombosis in hospitalized patients with liver cancer(P<0.05).Catheter duration of 1-6 months and catheter duration>6 months were protective factors for PICC-related thrombosis(P<0.05).The predictive model for PICC-related thrombosis was obtained as follows:P predictive probability=[exp(Logit P)]/[1+exp(Logit P)],where Logit P=age×1.907+KPS score×2.045+parenteral nutrition×9.467+catheter duration×0.506+tumor-node-metastasis(TNM)staging×2.844+distant metastasis×2.065+bone marrow suppression×2.082+activities of daily living impairment×13.926.ROC curve analysis showed an area under the curve(AUC)of 0.827(95%CI:0.724-0.929,P<0.001),with a corresponding optimal cut-off value of 0.612,sensitivity of 0.755,and specificity of 0.857.Calibration curve analysis showed good consistency between the predicted occurrence of PICC-related thrombosis and actual occurrence(P>0.05).ROC analysis showed AUCs of 0.888 and 0.729 for the training and validation sets,respectively.CONCLUSION Age,KPS score,parenteral nutrition,TNM staging,distant metastasis,bone marrow suppression,and activities of daily living impairment are independent risk factors for PICC-related thrombosis in hospitalized patients with liver cancer,while catheter duration is a protective factor for the disease.The predictive model has an AUC of 0.827,indicating high predictive accuracy and clinical value.
基金This work is supported by the National Key R&D Program of China(No.2017YFB1200800)the National Natural Science Foundation of China(No.11725210,11572281,51827810,51637009)+1 种基金the Fundamental Research Funds for the Central Universities(2018XZZX001-05)the National Student’s Platform for Innovation and Entrepreneurship Training Program(201910335115).
文摘Electromagnetic railgun attracts more and more attention due to its advantage in speed,cost,and obscurity.It is found that the rail should withstand huge mechanical and thermal shocks during the launching operation.The forms of rail failure are accompanied by gouge,grooving,transition,and arc ablation,etc.The service life of the rail has become a bottleneck restricting the development of electromagnetic railgun technology.A series of researches are carried out to solve rail failure,including analysing the failure mechanism and using various advanced rail materials.This paper provides a comprehensive review of rail materials,including material composition,preparation,microstructure,and properties.We begin from a short background of the requirement of the rail material.Then a detailed investigation of rail materials is described,and the performances of those materials are introduced.Finally,further development prospect of rail material is discussed.
基金Project supported by the National Natural Science Foundation of China （Nos. 11202183 and 50671092）, the National Science ＆ Tech- nology Pillar Program during the Eleventh Five-Year Plan Period （No. 2009BAG12A09）, the National High Technology Research and Development Program （863） of China （No. 2011AAllA101）, and the Zhejiang Provincial Natural Science Foundation of China （No. Y4100193）
基金Project supported by the National Natural Science Foundation of China(No.11202183)the National High-Tech R&D Program(863 Program)of China(No.2011AA11A101)+1 种基金the Public Projects of Zhejiang Province(No.2012C31023)the Zhejiang Provincial Natural Science Foundation of China(No.LQ12B01001)
基金Project supported by the National Nature Science Foundation of China(Grant Nos.51725801,U 1834207).
文摘This paper presents an analytical model to solve the linear wave diffraction problem by arrays of bottom-mounted cylinders with arbitrary smooth cross-section.Based on the assumption of ideal fluid and potential theory,the unknown coefficients of total velocity potential can be solved by system of linear equations,which are obtained from the boundary conditions.The accuracy of the present method is verified by comparing it with the numerical tool in terms of the wave force and wave mn-up.Multiple cylinders with different configurations are tested,the cross-section of which is circular with cosine perturbation.The results show that the proposed method could obtain an accurate prediction of the wave action with multiple cylinder problems.Finally,the diffraction wave is investigated on arrays of bottom-mounted cylinders with different cross-section and layout.The near-trapping problem with effects of the multi-body interaction are also investigated.
