We propose a method for calculating the nonradiative decay rates for polyatomic molecules including anharmonic effects of the potential energy surface(PES)in the Franck-Condon region.The method combines the n-mode rep...We propose a method for calculating the nonradiative decay rates for polyatomic molecules including anharmonic effects of the potential energy surface(PES)in the Franck-Condon region.The method combines the n-mode repre-sentation method to construct the ab initio PES and the nearly exact time-dependent density matrix renormalization group method(TD-DMRG)to simulate quantum dynamics.In addition,in the framework of TD-DMRG,we further develop an algorithm to calculate the final-state-resolved rate coefficient which is very useful to analyze the contribution from each vibrational mode to the transition process.We use this method to study the internal conversion(IC)process of azulene after taking into account the anharmonicity of the ground state PES.The results show that even for this semi-rigid molecule,the intramode anharmonicity enhances the IC rate significantly,and after considering the two-mode coupling effect,the rate increases even further.The reason is that the anharmonicity enables the C-H vibrations to receive electronic energy while C-H vibrations do not contribute on the harmonic PES as the Huang-Rhys factor is close to 0.展开更多
The concept of“prevention before disease”in Buddhism has deep roots in traditional Indian medicine and has been integrated into Buddhist philosophy.The Buddhist philosophy of“prevention before disease”is based on ...The concept of“prevention before disease”in Buddhism has deep roots in traditional Indian medicine and has been integrated into Buddhist philosophy.The Buddhist philosophy of“prevention before disease”is based on the cultivation of mindfulness through the practice of meditation.This philosophy has been integrated into modern medicine through the development of mindfulness-based interventions,which have been found to be effective in reducing symptoms of anxiety,depression,and chronic pain.The article also discusses the spread of Buddhist philosophy and its“prevention before disease”concept in different regions of the world and the potential benefits of integrating this philosophy into patient care.Here,we summarized the concept of“Prevention before Disease”in Buddhism and its specific content in Buddhist teachings and discussed its application&dissemination status in modern medicine.展开更多
Background:Diabetic kidney disease is now the principal cause of end-stage renal failure worldwide.Alprostadil combined with tripterygium glycosides tablet is a new method for diabetic kidney disease treatment.However...Background:Diabetic kidney disease is now the principal cause of end-stage renal failure worldwide.Alprostadil combined with tripterygium glycosides tablet is a new method for diabetic kidney disease treatment.However,there are currently few systematic reviews on treatment for alprostadil combined with tripterygium glycosides tablet.Therefore,a systematic review and meta-analysis was conducted to analyze the function of alprostadil combined with tripterygium glycosides tablet in the treatment of diabetic kidney disease.Methods:We searched Pubmed,Embase,the Cochrane Library,Chinese databases,and clinical trial for randomized controlled trials of alprostadil combined with tripterygium glycosides tablet in the treatment of diabetic kidney disease,including results from the foundation of database until August 5,2020.Two reviewers have independently performed literature screening,data extraction,and quality evaluation.This meta-analysis has been carried out by RevMan5.4 software.Results:Ten randomized controlled trials with 724 patients were involved.Compared with alprostadil alone,the combination of alprostadil and tripterygium glycosides tablet in treatment of diabetic kidney disease could reduce the level of 24-hour urine protein(95%CI(–2.05,–0.22),P=0.01),serum creatinine(95%CI(–5.01,–0.20),P=0.03),level of interleukin-6(95%CI(−4.57,−2.37),P<0.00001),tumor necrosis factor-α(95%CI(−4.57,−2.37),P<0.00001).The combined treatment could also improve the clinical efficacy(95%CI(1.09,1.25),P<0.0001),and reduce the occurrence of serious adverse events(95%CI(0.26,0.94),P=0.03).However,there is no association of two treatments in blood urea nitrogen(95%CI(–4.17,2.11),P=0.52),albumin(95%CI(–1.10,0.97),P=0.90),triglyceride(95%CI(−1.44,1.50),P=0.97).Conclusion:Alprostadil combined with tripterygium glycosides tablet contributes to protecting renal function,inhibiting inflammation,and reducing the occurrence of adverse events,which could be considered as a feasible therapy for diabetic kidney disease patients.However,some clinical variables did not accurately conclude due to the low quality of methodology and small sample sizes.More rigorous and more extensive trials are essential to validate our results.Trial registration:Systematic review registration:(CRD42020203725).展开更多
Objective:This study aimed to systematically evaluate the clinical efficiency and safety of moxibustion for the treatment of poststroke insomnia(PSI).Methods:We searched PubMed,the Cochrane Library,Embase,China Nation...Objective:This study aimed to systematically evaluate the clinical efficiency and safety of moxibustion for the treatment of poststroke insomnia(PSI).Methods:We searched PubMed,the Cochrane Library,Embase,China National Knowledge Infrastructure(CNKI),Wanfang Data Knowledge Service platform(Wanfang Data),Chinese Scientific Journal Database(VIP),and clinical rial for trandomized controlled trials on moxibustion as a treatment for PSI,including results from the creation of all databases until December 12,2020.The functional languages used were Chinese and English.Two reviewers independently performed the literature search,data extraction,and quality evaluation.The primary and secondary outcome measures were the effective rate and adverse events,respectively.The meta-analysis was carried out using RevMan5.4 software and Stata15.Results:Of the 11 trials,996 patients in China's Mainland were included.Compared to the control group,the combination of single moxibustion therapy or moxibustion combined with acupuncture in the treatment of DN could reduce the sleep quality score(SQS)(mean difference[MD]=-0.50,95%confidence interval[CI][-0.89,-0.11],Z=2.51,P=0.01),time to falling asleep score(MD=-0.39,95%CI[-0.49,-0.29],Z=7.79,P<0.00001),sleep time score(MD=-0.34,95%CI[-0.59,-0.09],Z=2.64,P=0.008),sleep efficiency score(MD=-0.30,95%CI[-0.52,-0.08],Z=2.69,P=0.007),sleep disorder score(MD=-0.29,95%CI[-0.49,-0.09],Z=2.85,P=0.004),daily function disturbance score(MD=-0.54,95%CI[-0.82,-0.26],Z=3.78,P=0.0002),Pittsburgh Sleep Quality Index aggregate score(MD=-2.30,95%CI[-2.97,-1.63],Z=6.71,P<0.00001),SPIEGEL aggregate score(MD=-7.62,95%CI[-8.12,-7.12],Z=29.75,P<0.00001),and stroke-specific quality of life aggregate score(MD=12.68,95%CI[0.92,24.44],Z=2.11,P=0.03).Conclusion:This study indicates that moxibustion contributes to the treatment of PSI.Nevertheless,more extensive trials are required to validate the results due to the small sample sizes,few reports on adverse effects,and high risk of bias in the included studies.展开更多
基金supported by the National Natural Science Foundation of China through the Project "Science Center for Luminescence from Molecular Aggregates(SCELMA)" (No.21788102)the Ministry of Science and Technology of China through the National Key R&D Plan (No.2017YFA0204501)supported by the National Natural Science Foundation of China (No.22003029)
文摘We propose a method for calculating the nonradiative decay rates for polyatomic molecules including anharmonic effects of the potential energy surface(PES)in the Franck-Condon region.The method combines the n-mode repre-sentation method to construct the ab initio PES and the nearly exact time-dependent density matrix renormalization group method(TD-DMRG)to simulate quantum dynamics.In addition,in the framework of TD-DMRG,we further develop an algorithm to calculate the final-state-resolved rate coefficient which is very useful to analyze the contribution from each vibrational mode to the transition process.We use this method to study the internal conversion(IC)process of azulene after taking into account the anharmonicity of the ground state PES.The results show that even for this semi-rigid molecule,the intramode anharmonicity enhances the IC rate significantly,and after considering the two-mode coupling effect,the rate increases even further.The reason is that the anharmonicity enables the C-H vibrations to receive electronic energy while C-H vibrations do not contribute on the harmonic PES as the Huang-Rhys factor is close to 0.
基金supported by the National Natural Science Foundation of China(81603438)he Natural Science Foundation of Tianjin(19JCZDJC37000)the Scientific Research Plan project of the Tianjin Municipal Education Commission(2020KJ163).
文摘The concept of“prevention before disease”in Buddhism has deep roots in traditional Indian medicine and has been integrated into Buddhist philosophy.The Buddhist philosophy of“prevention before disease”is based on the cultivation of mindfulness through the practice of meditation.This philosophy has been integrated into modern medicine through the development of mindfulness-based interventions,which have been found to be effective in reducing symptoms of anxiety,depression,and chronic pain.The article also discusses the spread of Buddhist philosophy and its“prevention before disease”concept in different regions of the world and the potential benefits of integrating this philosophy into patient care.Here,we summarized the concept of“Prevention before Disease”in Buddhism and its specific content in Buddhist teachings and discussed its application&dissemination status in modern medicine.
基金This work was supported by grants from the National Natural Science Foundation of China(81703968 and 81403333)Scientific Research Subject of Traditional Chinese Medicine/Integrative Chinese and Western Medicine of Health Commission of Tianjin(2017098).
文摘Background:Diabetic kidney disease is now the principal cause of end-stage renal failure worldwide.Alprostadil combined with tripterygium glycosides tablet is a new method for diabetic kidney disease treatment.However,there are currently few systematic reviews on treatment for alprostadil combined with tripterygium glycosides tablet.Therefore,a systematic review and meta-analysis was conducted to analyze the function of alprostadil combined with tripterygium glycosides tablet in the treatment of diabetic kidney disease.Methods:We searched Pubmed,Embase,the Cochrane Library,Chinese databases,and clinical trial for randomized controlled trials of alprostadil combined with tripterygium glycosides tablet in the treatment of diabetic kidney disease,including results from the foundation of database until August 5,2020.Two reviewers have independently performed literature screening,data extraction,and quality evaluation.This meta-analysis has been carried out by RevMan5.4 software.Results:Ten randomized controlled trials with 724 patients were involved.Compared with alprostadil alone,the combination of alprostadil and tripterygium glycosides tablet in treatment of diabetic kidney disease could reduce the level of 24-hour urine protein(95%CI(–2.05,–0.22),P=0.01),serum creatinine(95%CI(–5.01,–0.20),P=0.03),level of interleukin-6(95%CI(−4.57,−2.37),P<0.00001),tumor necrosis factor-α(95%CI(−4.57,−2.37),P<0.00001).The combined treatment could also improve the clinical efficacy(95%CI(1.09,1.25),P<0.0001),and reduce the occurrence of serious adverse events(95%CI(0.26,0.94),P=0.03).However,there is no association of two treatments in blood urea nitrogen(95%CI(–4.17,2.11),P=0.52),albumin(95%CI(–1.10,0.97),P=0.90),triglyceride(95%CI(−1.44,1.50),P=0.97).Conclusion:Alprostadil combined with tripterygium glycosides tablet contributes to protecting renal function,inhibiting inflammation,and reducing the occurrence of adverse events,which could be considered as a feasible therapy for diabetic kidney disease patients.However,some clinical variables did not accurately conclude due to the low quality of methodology and small sample sizes.More rigorous and more extensive trials are essential to validate our results.Trial registration:Systematic review registration:(CRD42020203725).
基金supported by the Special Research Project of the Traditional Chinese Medicine Industry(201107006)the School-level Scientific Research Project of Tianjin University of Traditional Chinese Medicine(XJ201801)。
文摘Objective:This study aimed to systematically evaluate the clinical efficiency and safety of moxibustion for the treatment of poststroke insomnia(PSI).Methods:We searched PubMed,the Cochrane Library,Embase,China National Knowledge Infrastructure(CNKI),Wanfang Data Knowledge Service platform(Wanfang Data),Chinese Scientific Journal Database(VIP),and clinical rial for trandomized controlled trials on moxibustion as a treatment for PSI,including results from the creation of all databases until December 12,2020.The functional languages used were Chinese and English.Two reviewers independently performed the literature search,data extraction,and quality evaluation.The primary and secondary outcome measures were the effective rate and adverse events,respectively.The meta-analysis was carried out using RevMan5.4 software and Stata15.Results:Of the 11 trials,996 patients in China's Mainland were included.Compared to the control group,the combination of single moxibustion therapy or moxibustion combined with acupuncture in the treatment of DN could reduce the sleep quality score(SQS)(mean difference[MD]=-0.50,95%confidence interval[CI][-0.89,-0.11],Z=2.51,P=0.01),time to falling asleep score(MD=-0.39,95%CI[-0.49,-0.29],Z=7.79,P<0.00001),sleep time score(MD=-0.34,95%CI[-0.59,-0.09],Z=2.64,P=0.008),sleep efficiency score(MD=-0.30,95%CI[-0.52,-0.08],Z=2.69,P=0.007),sleep disorder score(MD=-0.29,95%CI[-0.49,-0.09],Z=2.85,P=0.004),daily function disturbance score(MD=-0.54,95%CI[-0.82,-0.26],Z=3.78,P=0.0002),Pittsburgh Sleep Quality Index aggregate score(MD=-2.30,95%CI[-2.97,-1.63],Z=6.71,P<0.00001),SPIEGEL aggregate score(MD=-7.62,95%CI[-8.12,-7.12],Z=29.75,P<0.00001),and stroke-specific quality of life aggregate score(MD=12.68,95%CI[0.92,24.44],Z=2.11,P=0.03).Conclusion:This study indicates that moxibustion contributes to the treatment of PSI.Nevertheless,more extensive trials are required to validate the results due to the small sample sizes,few reports on adverse effects,and high risk of bias in the included studies.
