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激光加速质子束肿瘤治疗研究现状与展望 被引量:3
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作者 吕建锋 罗筠彬 +14 位作者 王超 马宇琦 赵兴益 吴笛 王科栋 赵家瑞 徐圣宣 耿易星 赵研英 朱昆 林晨 马文君 陈佳洱 颜学庆 杨根 《科学通报》 EI CAS CSCD 北大核心 2023年第9期1112-1124,共13页
质子放射治疗是现代癌症治疗的重要手段之一,由于其精确的靶区剂量递送和良好疗效而得到了广泛的关注.基于高功率激光器的激光质子加速技术有望通过小型化和低复杂度等优势为质子治疗提供具有竞争力的加速方案.同时,激光质子束还具有宽... 质子放射治疗是现代癌症治疗的重要手段之一,由于其精确的靶区剂量递送和良好疗效而得到了广泛的关注.基于高功率激光器的激光质子加速技术有望通过小型化和低复杂度等优势为质子治疗提供具有竞争力的加速方案.同时,激光质子束还具有宽能谱、超高瞬态流强和超短脉冲等特点,为探究超高剂量率放疗导致的生物学效应及可能的优势提供了有利的研究条件.在过去的数年里,我们借助北京大学紧凑型激光等离子体加速器以及在建的北京激光加速创新中心实验平台,陆续开展了涵盖激光质子加速、束流传输控制、辐射生物学和免疫学等方面的理论与实验研究,以探讨激光质子放疗的可行性与优势.本文从这些方面对国内外前沿研究进行了总结,并着重探讨了剂量递送与生物学效应方面的研究进展和面临的问题,最后对激光质子放疗的未来发展前景进行了讨论和展望. 展开更多
关键词 激光加速器 质子放疗 剂量递送 生物学效应
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Multiple charge ion beam generation with a 2.45 GHz electron cyclotron resonance ion source
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作者 Yuan Xu ShiXiang Peng +7 位作者 HaiTao Ren JiaMei Wen AiLin Zhang Tao Zhang JingFeng Zhang WenBin Wu ZhiYu Guo jiaer chen 《Science China(Physics,Mechanics & Astronomy)》 SCIE EI CAS CSCD 2017年第6期74-77,共4页
Multiple charge ions (MCIs) are necessary for increasing the output energy of particles in accelerators. In general, MCI beams are largely produced by electron beam ion source (EBIS) [1], laser ion source (LIS) [2], o... Multiple charge ions (MCIs) are necessary for increasing the output energy of particles in accelerators. In general, MCI beams are largely produced by electron beam ion source (EBIS) [1], laser ion source (LIS) [2], or high-frequency (mostly >5 GHz) electron cyclotron resonance (ECR) ion source [3]. Among these, only ECR ion source can operate in the continuous wave (CW) mode, while EBIS and LIS only support pulses. In addition, ECR ion source with lower frequency (mostly 2.45 GHz) are required primarily for generating single charge state ions, because the corresponding ECR field (875 Gs) is not sufficiently strong for MCI generation [4]. 展开更多
关键词 电子回旋共振离子源 多电荷离子 离子束 GHZ ECR离子源 MCIS 电子束离子源 激光离子源
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Plasma parameter diagnosis using hydrogen emission spectra of a quartz-chamber 2.45 GHz ECRIS at Peking University
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作者 WenBin Wu HaiTao Ren +8 位作者 ShiXiang Peng Yuan Xu JiaMei Wen Tao Zhang JingFeng Zhang AiLin Zhang Jiang Sun ZhiYu Guo jiaer chen 《Science China(Physics,Mechanics & Astronomy)》 SCIE EI CAS CSCD 2018年第4期69-74,共6页
A quartz-chamber 2.45 GHz electron cyclotron resonance ion source(ECRIS) was designed for diagnostic purposes at Peking University [Patent Number: ZL 201110026605.4]. This ion source can produce a maximum 84 m A hydro... A quartz-chamber 2.45 GHz electron cyclotron resonance ion source(ECRIS) was designed for diagnostic purposes at Peking University [Patent Number: ZL 201110026605.4]. This ion source can produce a maximum 84 m A hydrogen ion beam at 50 k V with a duty factor of 10%. The root-mean-square(RMS) emittance of this beam is less than 0.12π mm mrad. In our initial work,the electron temperature and electron density inside the plasma chamber had been measured with the line intensity ratio of noble gases. Based on these results, the atomic and molecular emission spectra of hydrogen were applied to determine the dissociation degree of hydrogen and the vibrational temperature of hydrogen molecules in the ground state, respectively. Measurements were performed at gas pressures from 4×10^(-4) to 1×10^(-3) Pa and at input peak RF power ranging from 1000 to 1800 W. The dissociation degree of hydrogen in the range of 0.5%-10% and the vibrational temperature of hydrogen molecules in the ground state in the range of 3500-8500 K were obtained. The plasma processes inside this ECRIS chamber were discussed based on these results. 展开更多
关键词 ECRIS 北京大学 氢离子 GHZ 房间 血浆 排放 诊断
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