Research and Application of a Multi-Field Co-Simulation Data Extraction Method Based on Adaptive Infinitesimal Element

Regarding the spatial profile extraction method of a multi-field co-simulation dataset,different extraction directions,locations,and numbers of profileswill greatly affect the representativeness and integrity of data.In this study,a multi-field co-simulation data extractionmethod based on adaptive infinitesimal elements is proposed.Themultifield co-simulation dataset based on related infinitesimal elements is constructed,and the candidate directions of data profile extraction undergo dimension reduction by principal component analysis to determine the direction of data extraction.Based on the fireworks algorithm,the data profile with optimal representativeness is searched adaptively in different data extraction intervals to realize the adaptive calculation of data extraction micro-step length.The multi-field co-simulation data extraction process based on adaptive microelement is established and applied to the data extraction process of the multi-field co-simulation dataset of the sintering furnace.Compared with traditional data extraction methods for multi-field co-simulation,the approximate model constructed by the data extracted from the proposed method has higher construction efficiency.Meanwhile,the relative maximum absolute error,root mean square error,and coefficient of determination of the approximationmodel are better than those of the approximation model constructed by the data extracted from traditional methods,indicating higher accuracy,it is verified that the proposed method demonstrates sound adaptability and extraction efficiency.

Glutaredoxin-1 alleviates acetaminophen-induced liver injury by decreasing its toxic metabolites

Excessive N-acetyl-p-benzoquinone imine(NAPQI)formation is a starting event that triggers oxidative stress and subsequent hepatocyte necrosis in acetaminophen(APAP)overdose caused acute liver failure(ALF).S-glutathionylation is a reversible redox post-translational modification and a prospective mechanism of APAP hepatotoxicity.Glutaredoxin-1(Glrx1),a glutathione-specific thioltransferase,is a primary enzyme to catalyze deglutathionylation.The objective of this study was to explored whether and how Glrx1 is associated with the development of ALF induced by APAP.The Glrx1 knockout mice(Glrx1^(-/-))and liver-specific overexpression of Glrx1(AAV8-Glrx1)mice were produced and underwent APAPinduced ALF.Pirfenidone(PFD),a potential inducer of Glrx1,was administrated preceding APAP to assess its protective effects.Our results revealed that the hepatic total protein S-glutathionylation(PSSG)increased and the Glrx1 level reduced in mice after APAP toxicity.Glrx1^(-/-)mice were more sensitive to APAP overdose,with higher oxidative stress and more toxic metabolites of APAP.This was attributed to Glrx1 deficiency increasing the total hepatic PSSG and the S-glutathionylation of cytochrome p4503a11(Cyp3a11),which likely increased the activity of Cyp3a11.Conversely,AAV8-Glrx1 mice were defended against liver damage caused by APAP overdose by inhibiting the S-glutathionylation and activity of Cyp3a11,which reduced the toxic metabolites of APAP and oxidative stress.PFD precede administration upregulated Glrx1 expression and alleviated APAP-induced ALF by decreasing oxidative stress.We have identified the function of Glrx1 mediated PSSG in liver injury caused by APAP overdose.Increasing Glrx1 expression may be investigated for the medical treatment of APAP-caused hepatic injury.

A dilute fluorine-free electrolyte design for high-voltage hybrid aqueous batteries

Fluorinated salts and/or high salt concentrations are usually necessary to produce protective films on the electrodes for high-voltage aqueous batteries,yet these approaches increase the cost,toxicity and reaction resistances of battery.Herein,we report a dilute fluorine-free electrolyte design to overcome this dilemma.By using the LiClO_(4) salt and polyethylene glycol dimethyl ether(PED)solvent and optimizing the LiClO_(4)/PED/H_(2)O molar ratio,we formulate a 1 mol kg^(-1)3 V-class hybrid aqueous electrolyte that enables reversible charge/discharge of 2.5 V LiMn_(2)O_(4)|Li_(4)Ti_(5)O_(12) full cell at both low(0.5C,92.4%capacity retention in 300 cycles)and high(5C,80.4%capacity retention in 2000 cycles)rates.This excellent performance is reached even without the generation of protective film on either anode or cathode as identified by in/ex situ characterizations.The selection of appropriate ingredients that have both high stability and strong interactions with water is critical to widen the potential window of electrolyte while suppressing parasitic reactions on the electrodes.This work suggests that expensive and toxic fluorinate salts are no longer necessary for 3 V-class aqueous electrolytes,boosting the development of low-cost,environmentally-friendly,high-power and high-energy-density aqueous batteries.

A novel monoclinic phase and electrically tunable magnetism of van der Waals layered magnet CrTe2

Exploring the novel structural phase of van der Waals(vdW) magnets would promote the development of spintronics.Here, through first-principles calculations, we report a novel monoclinic structure of vdW layered 1T-CrTe2, which is one of the popular vdW magnets normally exhibiting a trigonal structure. The new monoclinic phase emerges from a switchable magnetic state between ferromagnetism and antiferromagnetism through changing hole doping concentration, which suggests a practical approach to obtain such a structure. The results of phonon dispersion and energy analysis convince us that the monoclinic structure is a metastable phase even without hole doping. When the hole doping concentration increases,the stability analysis indicates the preference for a novel monoclinic phase rather than a conventional trigonal phase, and meanwhile, the magnetic properties are accordingly tuned. This work provides new insights into the phase engineering of the chalcogenide family and the electrical control of magnetism of vdW layered magnets.

Optical Tunable MoiréExcitons in Twisted Hexagonal GaTe Bilayers

Optical fine-tunable layer-hybridized Moiréexcitons are highly in demand for emerging many-body states in two-dimensional semiconductors.We report naturally confined layer-hybridized bright Moiréexcitons with long lifetimes in twisted hexagonal GaTe bilayers,using ab initio many-body perturbation theory and the Bethe–Salpeter equation.Due to the hybridization of electrons and holes between layers,which enhances the brightness of excitons,the twisted bilayer system becomes attractive for optical applications.We find that in both R and H-type stacking Moirésuperlattices,more than 200 meV lateral quantum confinements occur on exciton energies,which results in two scenarios:(1)The ground state bright excitons XA are found to be trapped at two high-symmetry points,with opposite electric dipoles in the R-stacking Moirésupercell,forming a honeycomb superlattice of nearest-neighbor dipolar attraction.(2)For H-stacking case,the XA is found to be trapped at only one high-symmetry point exhibiting a triangular superlattice.Our results suggest that twisted h-GaTe bilayer is one of the promising systems for optical fine-tunable excitonic devices and provide an ideal platform for realizing strong correlated Bose–Hubbard physics.

A cross-species co-functional gene network underlying leaf senescence

The complex leaf senescence process is governed by various levels of transcriptional and translational regulation.Several features of the leaf senescence process are similar across species,yet the extent to which the molecular mechanisms underlying the process of leaf senescence are conserved remains unclear.Currently used experimental approaches permit the identification of individual pathways that regulate various physiological and biochemical processes;however,the large-scale regulatory network underpinning intricate processes like leaf senescence cannot be built using these methods.Here,we discovered a series of conserved genes involved in leaf senescence in a common horticultural crop(Solanum lycopersicum),a monocot plant(Oryza sativa),and a eudicot plant(Arabidopsis thaliana)through analyses of the evolutionary relationships and expression patterns among genes.Our analyses revealed that the genetic basis of leaf senescence is largely conserved across species.We also created a multi-omics workf low using data from more than 10000 samples from 85 projects and constructed a leaf senescence-associated co-functional gene network with 2769 conserved,high-confidence functions.Furthermore,we found that the mitochondrial unfolded protein response(UPR^(mt))is the central biological process underlying leaf senescence.Specifically,UPR^(mt) responds to leaf senescence by maintaining mitostasis through a few cross-species conserved transcription factors(e.g.NAC13)and metabolites(e.g.ornithine).The co-functional network built in our study indicates that UPR^(mt) figures prominently in cross-species conserved mechanisms.Generally,the results of our study provide new insights that will aid future studies of leaf senescence.

基于浮式风机实验与数值分析的方法论与挑战研究综述

Due to the dissimilar scaling issues,the conventional experimental method of FOWTs can hardly be used directly to validate the full-scale global dynamic responses accurately.Therefore,it is of absolute necessity to find a more accurate,economic and efficient approach,which can be utilized to predict the full-scale global dynamic responses of FOWTs.In this paper,a literature review of experimental-numerical methodologies and challenges for FOWTs is made.Several key challenges in the conventional basin experiment issues are discussed,including scaling issues;coupling effects between aero-hydro and structural dynamic responses;blade pitch control strategies;experimental facilities and calibration methods.Several basin experiments,industrial projects and numerical codes are summarized to demonstrate the progress of hybrid experimental methods.Besides,time delay in hardware-in-the-loop challenges is concluded to emphasize their significant role in real-time hybrid approaches.It is of great use to comprehend these methodologies and challenges,which can help some future researchers to make a footstone for proposing a more efficient and functional hybrid basin experimental and numerical method.

Recent developments on catalytic membrane for gas cleaning

Catalytic membrane, a novel membrane separation technology that combines catalysis and separation, exhibits significant potential in gas purification such as formaldehyde, toluene and nitrogen oxides(NO_x). The catalytic membrane can remove solid particles through membrane separation and degrade gaseous pollutants to clean gas via a catalytic reaction to achieve green emissions. In this review, we discussed the recent developments of catalytic membranes from two aspects: preparation of catalytic membrane and its application in gas cleaning.Catalytic membranes are divided into organic catalytic membranes and inorganic catalytic membranes depending on the substrate materials. The organic catalytic membranes which are used for low temperature operation(less than 300 °C) are prepared by modifying the polymers or doping catalytic components into the polymers through coating, grafting, or in situ growth of catalysts on polymeric membrane. Inorganic catalytic membranes are used at higher temperature(higher than 500 °C). The catalyst and inorganic membrane can be integrated through conventional deposition methods, such as chemical(physical) vapor deposition and wet chemical deposition. The application progress of catalytic membrane is focused on purifying indoor air and industrial exhaust to remove formaldehyde, toluene, NO_x and PM2.5, which are also summarized. Perspectives on the future developments of the catalytic membranes are provided in terms of material manufacturing and process optimization.

Molecular and atomic manipulation of metal-organic framework-derived LiCoMnO_(4):An oxygen-deficient strategy for advanced lithium storage

As a novel class of high-voltage cathode materials,spinel lithium transition metal oxides have been faced with demerits including pronounced structural instability caused by Jahn-Teller distortion(especially at the lower voltage region)and severe capacity degradation despite their intriguing electrochemical properties.To extend their functionalities as broad-voltage cathodes,the sacrificial template method has been regarded as a promising way to realize structural and compositional control for desirable electrochemical behaviors.Herein,we report a synthetic protocol to directionally prepare Li Co Mn O_(4)(LCMO)using carboxyl-based metal-organic frameworks(MOFs)as self-sacrificing templates.Impressively,LCMO derived from Co Mn-BDC(H_(2)BDC=1,4-benzenedicarboxylate)displays superior electrochemical performances with a specific capacity of 151.6 m Ah g^(-1)at 1 C(150 m A g^(-1))after 120 cycles and excellent rate capacity of 91.9 m Ah g^(-1)at 10 C due to the morphology control,microstructural modulation,and atomic manipulation of the MOF precursor.Bestowed by the optimized atomic and electronic structure,abundant oxygen vacancies,and the nanostructure retained from MOF precursors,LCMO materials display extraordinary electrochemical properties,which have been extensively verified by both experimental and theoretical studies.This work not only provides guidelines for the directional design of spinel materials at molecular and atomic levels but also sheds light on the practical use of LIBs with broad range voltage.

Insight into the characteristics of an important evolutionary model bird(Geospiza magnirostris)mitochondrial genome through comparison

Darwin’s finches are the most classic case of evolution.Early studies on the evolution of this species were mainly based on morphology.Until now,the mitochondrial genome of Geospiza magnirostris has been sequenced and the study explored the characteristics of the complete genome of G.magnirostris and verified the evolutionary position of it.The 13 PCGs initiated by ATN codons.The stop codons of three PCGs(ND2,COX3 and ND4)were incomplete,with only T-or TA-replacing complete form TAA or TAG.All the tRNA genes expressed a typical cloverleaf secondary structure,except for tRNA^(Ser1)(AGY),whose dihydrouridine(DHU)arm was lack and instead with a simple loop.In the sequence of the control region of G.magnirostris,we found six simple repeat tandem sequences with a total length of 42 bp.Two characteristic conserved overlapping junction(ATGCTAA)and(CAAGAAAG)were observed as reported for eight selected Passeriformes birds.A special conserved overlapping junction(ATCTTACC)involved in mitochondrial transcription termination was found between tRNA^(Tyr) and COX1 in G.magnirostris’s control region.Four most frequently used amino acids in G.magnirostris’s PCGs were Leu1(CUN),Ile,Thr,Ala.The codon usage of G.magnirostris was relatively average,and there was no particular bias.The ratio Ka/Ks results showed that G.magnirostris receives less natural selection pressure.The phylogenetic relationships and cluster analysis of relative codon usage showed that G.magnirostris and Thraupis episcopus clustered in one branch.The phylogenetic position of G.magnirostris was consistent with the traditional taxonomic of Thraupis.The results supported the conclusion that G.magnirostris belongs to the morphological classification of the family Thraupidae.

Kinetic study of key species and reactions of atmospheric pressure pulsed corona discharge in humid air

In this study, we examined the key particles and chemical reactions that substantially influence plasma characteristics. In summarizing the chemical reaction model for the discharge process of N_(2)–O_(2)–H_(2)O(g)mixed gases, 65 particle types and 673 chemical reactions were investigated. On this basis, a global model of atmospheric pressure humid air discharge plasma was developed, with a focus on the variation of charged particles densities and chemical reaction rates with time under the excitation of a 0–200 Td pulsed electric field. Particles with a density greater than 1% of the electron density were classified as key particles. For such particles, the top ranking generation or consumption reactions(i.e. where the sum of their rates was greater than 95% of the total rate of the generation or consumption reactions) were classified as key chemical reactions. On the basis of the key particles and reactions identified, a simplified global model was derived. A comparison of the global model with the simplified global model in terms of the model parameters, particle densities, reaction rates(with time), and calculation efficiencies demonstrated that both models can adequately identify the key particles and chemical reactions reflecting the chemical process of atmospheric pressure discharge plasma in humid air. Thus, by analyzing the key particles and chemical reaction pathways, the charge and substance transfer mechanism of atmospheric pressure pulse discharge plasma in humid air was revealed, and the mechanism underlying water vapor molecules’ influence on atmospheric pressure air discharge was elucidated.

Anti-JPEG Compression Steganography Based on the High Tense Region Locating Method

Robust data hiding techniques attempt to construct covert communication in a lossy public channel.Nowadays,the existing robust JPEG steganographic algorithms cannot overcome the side-information missing situation.Thus,this paper proposes a new robust JPEG steganographic algorithm based on the high tense region location method which needs no side-information of lossy channel.First,a tense region locating method is proposed based on the Harris-Laplacian feature point.Then,robust cover object generating processes are described.Last,the advanced embedding cost function is proposed.A series of experiments are conducted on various JPEG image sets and the results show that the proposed steganographic algorithm can resist JPEG compression efficiently with acceptable performance against steganalysis statistical detection libraries GFR(Gabor Filters Rich model)and DCTR(Discrete Cosine Transform Residual).

氟喹诺酮酸酯的ESI-MS裂解研究

氟喹诺酮酸酯对养殖业和人类健康存在潜在危害,发展其分析检测方法具有重要的意义。本论文制备了七种氟喹诺酮酸酯,并在ESI质谱仪的正离子测试模式下,获取它们的MS2裂解图谱。结果显示七种氟喹诺酮酸酯均优先断裂酯基中的C-O键,产生三种高强度的碎片离子峰:[M+H]+、[M+2H-Y]+和[M-Y-16]+(Y为酯基中烷基的质量数)。这些碎片可以作为定性离子,用于鉴定氟喹诺酮酸酯.

Mantle contributions to granitoids associated with Sn mineralization:Geochemical and isotopic evidence from the giant Dachang deposit,South China

Major Sn deposits are commonly linked to crust-derived and highly evolved granites,with magma generation aided by mantle heating.However,whether and how the mantle components contribute to Sn polymetallic mineralization remains unclear.In this study,in combination with a compilation of equivalent data in the region,we provide new constraints on this issue based on detailed investigations on the petrogenesis and metallogenic significance of granitoids including the causative batholith and later granodiorite porphyry dike in the giant Dachang Sn deposit from South China.The former has zircon U-Pb ages of 93-91 Ma and belongs to highly evolved S-type biotite granite,which experienced fractionation of massive feldspar.The latter shows zircon U-Pb ages of 90 Ma and displays I-type granite features.The batholith was mainly derived from the dehydration melting of biotite in the metasedimentary sources,as revealed by the relatively low whole-rock Pb contents(<30 ppm)and high Ba/Pb ratios(2.71-17.1)and initial T(ti-zr)of 790℃.Compared with the adjacent crust-derived S-type granites(-24.8--5.1)and I-type granites(-11.0 to-5.2),the Dachang S-type biotite granites present higher zirconεHf(t)values(-9.1 to-2.1).Furthermore,the low magmatic zirconδ18O values(6.2‰)and higher apatite LREE(3277-4114 ppm)and Sr(1137-1357 ppm)contents than of arc-type basic rocks were discerned.These characteristics jointly hint the contributions of mantle components.The higher initial T(ti-zr)(>850℃),whole-rock Mg#(52 to 58),apatiteεNd(t)(-9.2 to-6.5)and zirconεHf(t)(-7.6 to 2.5)values but lower zirconδ18O values(6.33 to 8.30‰)of the later granodiorite porphyry dike than those of the batholith also suggest that mantle material was involved in the generation of the dikes,which is evident by the variational features of zircon and apatite trace elements.In addition,at the zircon Hf<12000 ppm and Eu/Eu*>0.05,the higher zirconΔFMQ values(mostly from-1.8 to 2.0)and H2O contents(100-1100 ppm)of the Dachang granitoids than the pure crust-derived S-type granites(ΔFMQ=mostly from-3.7 to-1.5;H2O<100 ppm)imply that mantle materials involved are relatively rich in water and oxidized.These suggest that the addition of mantle components is conducive to the extraction of Sn from metasedimentary sources,and moderately facilitates the increase of oxygen fugacity which still maintains the incompatibility of Sn in magmas withΔFMQ<2.Also,the involvement of mantle components upgrades the H2O contents in S-type magmas,favoring the migration of ore-forming elements from magmas to hydrothermal fluids.The sediment-derived causative granites displayed higherεHf(t)andεNd(t)values with greater Sn tonnages of their associated world-class Sn polymetallic deposits,supporting the opinion that the contributions of mantle components play an important role in the generation of giant Sn deposits.

Efficient terahertz generation from van der Waalsα-In_(2)Se_(3)

Two-dimensional(2D)van der Waals materials have attracted tremendous attention due to their versatile physical properties and flexible manipulation approaches.Among the various types of van der Waals materials,α-In_(2)Se_(3)is remarkable for its intrinsic 2D ferroelectricity and high-performance opto-electronic properties.However,the study of theα-In_(2)Se_(3)system in terahertz(THz)radiation is scarce,although it is promising for electrically controlled THz field manipulation.We investigate theα-In_(2)Se_(3)in different thicknesses and report that the THz generation efficiency induced by femtosecond laser pulses can be largely improved by reducing the thickness from the bulk.Furthermore,we reveal the surge current in thin film coupled with THz emission exhibits a different Auger recombination mode,which is helpful in understanding the mechanism and provides insights into the design of 2D highly efficient THz devices.

The blood lactate/serum albumin ratio might represent a good prognostic indicator of 28-day mortality in patients with acute respiratory distress syndrome:a retrospective observational study

Background:Acute respiratory distress syndrome(ARDS)is an acute inflammatory lung injury with a high mortality rate.However,previous ARDS prognostic scoring systems or predictors have been limited by complex formulas that are relatively expensive and inconvenient to obtain.Thus,this study aimed to explore the clinical significance of the blood lactate/serum albumin ratio(LAR)in assessing the prognosis of ARDS patients and compare it with other indicators related to 28-day mortality in ARDS patients.Methods:We conducted a single-center retrospective study involving patients who fulfilled the Berlin definition of ARDS between 2016 and 2021.Clinical data were collected from medical records within 24 hours after ARDS diagnosis.The LAR,neutrophil-to-lymphocyte ratio,and monocyteto-lymphocyte ratio(MLR)were calculated.The primary clinical outcome was 28-day mortality.The risk factors for 28-day mortality were determined using conditional logistic regression analysis.The receiver operating characteristic curve was used to evaluate the area under the curve(AUC).Results:A total of 276 ARDS patients met the inclusion criteria and were divided into surviving and nonsurviving groups according to 28-day mortality.There were significant differences in the Acute Physiologic Assessment and Chronic Health Evaluation II scores,Sequential Organ Failure Assessment scores,MLRs,and LARs between the surviving and nonsurviving groups.The AUC for the LAR was 0.790(P<0.001),whereas the AUCs for the Acute Physiologic Assessment and Chronic Health Evaluation II score,Sequential Organ Failure Assessment score,neutrophil-to-lymphocyte ratio,and MLR were 0.584,0.599,0.524,and 0.587,respectively.After grouping according to an LAR optimal cutoff value of 0.07,28-day mortality was significantly higher in the high-LAR group than in the low-LAR group(47.18 vs.12.69,P<0.001).Conclusion:The LAR is an independent risk factor for 28-day mortality in ARDS patients and can be used to assess the severity of ARDS to a certain extent,making it superior to other commonly used indicators.

Costunolide covalently targets NACHT domain of NLRP3 to inhibit inflammasome activation and alleviate NLRP3-driven inflammatory diseases

The NLRP3 inflammasome’s core and most specific protein,NLRP3,has a variety of functions in inflammation-driven diseases.Costunolide(COS)is the major active ingredient of the traditional Chinese medicinal herb Saussurea lappa and has anti-inflammatory activity,but the principal mechanism and molecular target of COS remain unclear.Here,we show that COS covalently binds to cysteine 598 in NACHT domain of NLRP3,altering the ATPase activity and assembly of NLRP3 inflammasome.We declare COS’s great anti-inflammasome efficacy in macrophages and disease models of gouty arthritis and ulcerative colitis via inhibiting NLRP3 inflammasome activation.We also reveal that theα-methylene-γ-butyrolactone motif in sesquiterpene lactone is the certain active group in inhibiting NLRP3 activation.Taken together,NLRP3 is identified as a direct target of COS for its anti-inflammasome activity.COS,especially theα-methylene-γ-butyrolactone motif in COS structure,might be used to design and produce novel NLRP3 inhibitors as a lead compound.

^(16)O具有类Hoyle结构的新证据

多年来的研究认为,^(12)C中位于7.65 MeV的第二个0+态,也就是通常说的Hoyle state,具有类似玻色爱因斯坦凝聚(BEC)的状态.但对于更重的核体系,如^(16)O,^(20)Ne,^(24)Mg等,尽管已有多种理论预言,但多年来对于类BEC态的实验研究尚未给出明确的结论.近期北京串列加速器国家实验室开展的非弹散射实验给出了^(16)O中存在类似4α-BEC状态的新证据.实验使用96 MeV的^(16)0束流轰击0.98μm的^(12)C靶,采用多套双面硅微条带电粒子望远镜对反应末态粒子进行探测,在^(16)O衰变中实现了4个α粒子的准确识别(PID)和符合测量.在此基础上获得了高分辨的反应Q值谱并重建了清晰的4α共振态.其中在阈值附近观察到4个高显著度(大部分高于5σ)的共振态,它们按照^(12)C(Hoyle state)+α的特征模式衰变,与理论预言的类Hoyle-BEC结构及其转动带特征相一致.本观测结果将推动进一步的理论研究,以及实验上对上述共振态做更多物理量的观测.

ncFO:A Comprehensive Resource of Curated and Predicted ncRNAs Associated with Ferroptosis

Ferroptosis is a form of regulated cell death driven by the accumulation of lipid hydroperoxides.Regulation of ferroptosis might be beneficial to cancer treatment.Non-coding RNAs(ncRNAs)are a class of RNA transcripts that generally cannot encode proteins and have been demonstrated to play critical roles in regulating ferroptosis.Herein,we developed ncFO,the ncRNA-ferroptosis association database,to document the manually curated and predicted ncRNAs that are associated with ferroptosis.Collectively,ncFO contains 90 experimentally verified entries,including 46 microRNAs(miRNAs),21 long non-coding RNAs(lncRNAs),and 17 circular RNAs(circRNAs).In addition,ncFO also incorporates two online prediction tools based on the regulation and co-expression of ncRNA and ferroptosis genes.Using default parameters,we obtained 3260 predicted entries,including 598 miRNAs and 178 lncRNAs,by regulation,as well as 2,592,661 predicted entries,including 967 miRNAs and 9632 lncRNAs,by ncRNA-ferroptosis gene co-expression in more than 8000 samples across 20 cancer types.The detailed information of each entry includes ncRNA name,disease,species,tissue,target,regulation,publication time,and PubMed identifier.ncFO also provides survival analysis and differential expression analysis for ncRNAs.In summary,ncFO offers a user-friendly platform to search and predict ferroptosisassociated ncRNAs,which might facilitate research on ferroptosis and discover potential targets for cancer treatment.

肩袖损伤外科治疗研究热点与动态的可视化分析

目的基于Web of science(WOS)核心合集数据库,运用VOSviewer和Citespace等软件对肩袖撕裂外科治疗做可视化分析,以探究研究现状及研究热点。方法在WOS核心数据集中进行检索,时间跨度设为2000年1月至2022年4月,检索策略:#1 rotator cuff tear*(主题)or rotator cuff injur*(主题)or shoulder rotator cuff rupture(主题)or shoulder rotator cuff injur*(主题),#2 surgery(主题)or arthroscop*(主题),(#1)AND#2。结果共检索出4953篇施引文献和40003篇被引文献,肩袖撕裂领域研究文献持续增加,《肩肘外科杂志》《关节镜外科手术杂志》等主要刊载杂志占比超过40%。研究成果和国家机构合作主要集中在欧美,其他地区联系欠密切。根据被引文献分析制作时间线图谱,近年来腱-骨平面愈合、上囊关节重建、肌腱转位术成为该领域的研究热点。结论肩袖损伤外科治疗领域近二十年的发展可大致分为三个阶段,即关于肩袖损伤分类、临床表现及关节镜修复术式的初步阶段;发病危险因素、富血小板血浆(platelet-rich plasma,PRP)等生物治疗的探索阶段;腱-骨平面愈合、上囊关节重建、肌腱转位术等手术技术改进的深入探索阶段,相信未来在手术治疗策略上将会有进一步的突破。