At the EAST tokamak, the ion temperature(T_(i)) is observed to be clamped around 1.25 keV in electron cyclotron resonance(ECR)-heated plasmas, even at core electron temperatures up to 10 keV(depending on the ECR heati...At the EAST tokamak, the ion temperature(T_(i)) is observed to be clamped around 1.25 keV in electron cyclotron resonance(ECR)-heated plasmas, even at core electron temperatures up to 10 keV(depending on the ECR heating power and the plasma density). This clamping results from the lack of direct ion heating and high levels of turbulence-driven transport. Turbulent transport analysis shows that trapped electron mode and electron temperature gradient-driven modes are the most unstable modes in the core of ECR-heated H-mode plasmas. Nevertheless, recently it was found that the T_(i)/T_(e)ratio can increase further with the fraction of the neutral beam injection(NBI) power, which leads to a higher core ion temperature(Ti0). In NBI heating-dominant H-mode plasmas, the ion temperature gradient-driven modes become the most unstable modes.Furthermore, a strong and broad internal transport barrier(ITB) can form at the plasma core in high-power NBI-heated H-mode plasmas when the T_(i)/T_(e)ratio approaches ~1, which results in steep core Teand Tiprofiles, as well as a peaked neprofile. Power balance analysis shows a weaker Teprofile stiffness after the formation of ITBs in the core plasma region, where Ticlamping is broken,and the core Tican increase further above 2 keV, which is 80% higher than the value of Ticlamping in ECR-heated plasmas. This finding proposes a possible solution to the problem of Ticlamping on EAST and demonstrates an advanced operational regime with the formation of a strong and broad ITB for future fusion plasmas dominated by electron heating.展开更多
目的:系统评价宫瘤宁作为辅助疗法治疗子宫肌瘤的有效性和安全性。方法:检索数据库中国知网、万方、维普、PubMed、Cochrane Library、Embase、Web of Science以及中国临床试验注册系统、美国临床试验注册系统中有关宫瘤宁辅助治疗子宫...目的:系统评价宫瘤宁作为辅助疗法治疗子宫肌瘤的有效性和安全性。方法:检索数据库中国知网、万方、维普、PubMed、Cochrane Library、Embase、Web of Science以及中国临床试验注册系统、美国临床试验注册系统中有关宫瘤宁辅助治疗子宫肌瘤的临床随机对照试验。检索时限为各数据库建库至2023年3月20日。对符合纳入排除标准的研究采用“偏倚风险评估工具”进行文献质量评价,采用GRADE工具进行证据质量评价,应用RevMan5.3进行数据分析。结果:最终纳入20项研究,共1907例患者。15项研究的meta分析结果显示,宫瘤宁联合米非司酮在提高有效率方面优于单独使用米非司酮[RR=1.22,95%CI=(1.11,1.33),P<0.001]。因异质性较大,采用随机效应模型对纳入的研究进行合并。在缩小子宫肌瘤体积[MD=−4.09 cm^(3),95%CI(−5.16,−3.02),P<0.001],缩小子宫体积[MD=−23.22 cm^(3),95%C(I−29.10,−17.33),P<0.001],以及降低女性激素水平如孕激素水平、雌激素水平、促卵泡生成激素和促黄体生成激素等方面优于对照组(均P<0.001)。10项研究报告了不良事件。纳入研究的方法质量不高,存在中等偏倚风险。结论:与仅使用西医常规疗法相比,联合使用宫瘤宁在提高有效率方面有一定优势,在缩小子宫肌瘤体积、缩小子宫体积和降低女性激素水平等方面体现出一定优势趋势,但仍需更多质量高且设计严谨的研究进行验证。展开更多
A new multi-band and high-speed endoscope diagnostic for the observation of visible light has been successfully developed on the Experimental Advanced Superconducting Tokamak.The mirror with an aperture is designed at...A new multi-band and high-speed endoscope diagnostic for the observation of visible light has been successfully developed on the Experimental Advanced Superconducting Tokamak.The mirror with an aperture is designed at the head of the optical system.Based on two dichroic mirrors,the system is divided into three imaging mirror groups with different bands,i.e.B(380-500 nm),G(500-580 nm)and R(580-750 nm)bands,and its focal length is 16 mm with a relatively large aperture of D/f=1:4.The spatial resolution is less than 5 mm near the object distance of 1750 mm with the camera NAC ACS-1 M60.This optical system will be used to contrastively study both the spatial distribution and time evolution of different impurities in the same field of view.The experimental results confirm that it can be applied to the recognition of plasma boundary and related physical research.展开更多
Objective:To uncover and identify the hot topic and frontier of Chinese medicines treatment of type 2 diabetes mellitus(T2DM).Methods:Web of Science TM was searched for published articles for Chinese medicines treatme...Objective:To uncover and identify the hot topic and frontier of Chinese medicines treatment of type 2 diabetes mellitus(T2DM).Methods:Web of Science TM was searched for published articles for Chinese medicines treatment of T2DM ranging from January 1st,2002 to July 6th,2016.Knowledge maps of the international Chinese medicines treatment of T2DM are visualized by using document cooccurrence analysis and word frequency analysis(Institution and Journal),co-citation clustering analysis(Co-reference),keyword co-occurrence clustering analysis with CiteSpac III,a tool of scientometrics.Results:Universidad Nacional Autonoma de Mexico is the institution with the highest number of published papers that had been cited in this field,while China has four institutions among the top 10.The journal of the highest frequency of co-cited journal was Diabetes Care,a core one in the field.Keywords co-occurrence network was composed of 185 nodes,541 lines,and divided into 10 clusters.Co-citation network of co-reference was composed of 407 nodes,1199 lines,and divided into 20 clusters.Using Chinese medicine to improve insulin resistance and Chinese medicine research on blood glucose control are the hot topics.The frontier contains two aspects:new drugs development and application of intestinal insulin treatment and development and use of traditional Chinese medicine antidiabetic plants.Conclusion:Institutions from China still plays a major role in TCM-focused T2DM studies.The effect of TCM herbs on insulin resistance is the hot topic of the domain.Developing new TCM herbal medicine that regulates incretin effect is the domain frontier.Research on the Chinese medicines treatment of T2DM needs more high-quality evidence to support,and its mechanism requires further exploration.展开更多
The fractional Feynman-Kac equations describe the distributions of functionals of non-Brownian motion, or anomalous diffusion, including two types called the forward and backward fractional Feynman-Kac equations, wher...The fractional Feynman-Kac equations describe the distributions of functionals of non-Brownian motion, or anomalous diffusion, including two types called the forward and backward fractional Feynman-Kac equations, where the nonlocal time-space coupled fractional substantial derivative is involved. This paper focuses on the more widely used backward version. Based on the newly proposed approximation operators for fractional substantial derivative, we establish compact finite difference schemes for the backward fractional Feynman-Kac equation. The proposed difference schemes have the q-th(q = 1, 2, 3, 4) order accuracy in temporal direction and fourth order accuracy in spatial direction, respectively. The numerical stability and convergence in the maximum norm are proved for the first order time discretization scheme by the discrete energy method, where an inner product in complex space is introduced. Finally, extensive numerical experiments are carried out to verify the availability and superiority of the algorithms. Also, simulations of the backward fractional Feynman-Kac equation with Dirac delta function as the initial condition are performed to further confirm the effectiveness of the proposed methods.展开更多
III-nitride materials are of great importance in the development of modern optoelectronics,but they have been limited over years by low light utilization rate and high dislocation densities in heteroepitaxial films gr...III-nitride materials are of great importance in the development of modern optoelectronics,but they have been limited over years by low light utilization rate and high dislocation densities in heteroepitaxial films grown on foreign substrate with limited refractive index contrast and large lattice mismatches.Here,we demonstrate a paradigm of high-throughput manufacturing bioinspired microstructures on warped substrates by flexible nanoimprint lithography for promoting the light extraction capability.We design a flexible nanoimprinting mold of copolymer and a two-step etching process that enable high-efficiency fabrication of nanoimprinted compound-eye-like Al2O3 microstructure(NCAM)and nanoimprinted compound-eye-like SiO_(2)microstructure(NCSM)template,achieving a 6.4-fold increase in throughput and 25%savings in economic costs over stepper projection lithography.Compared to NCAM template,we find that the NCSM template can not only improve the light extraction capability,but also modulate the morphology of AlN nucleation layer and reduce the formation of misoriented GaN grains on the inclined sidewall of microstructures,which suppresses the dislocations generated during coalescence,resulting in 40%reduction in dislocation density.This study provides a low-cost,high-quality,and high-throughput solution for manufacturing microstructures on warped surfaces of III-nitride optoelectronic devices.展开更多
为了解决小分子有机正极在钠离子电池(SIBs)中的溶解问题,我们提出了一种有效的有机电极表面自碳化策略,并制备了新型可溶性小分子有机化合物NTCDI-DAQ对该策略进行验证.通过对惰性气氛下碳化温度和碳化时间的精确控制,在NTCDI-DAQ颗粒...为了解决小分子有机正极在钠离子电池(SIBs)中的溶解问题,我们提出了一种有效的有机电极表面自碳化策略,并制备了新型可溶性小分子有机化合物NTCDI-DAQ对该策略进行验证.通过对惰性气氛下碳化温度和碳化时间的精确控制,在NTCDI-DAQ颗粒表面成功形成了厚度为30-40 nm的碳层,可在不影响NTCDI-DAQ电化学行为的前提下,有效消除其溶解问题.在半电池中,NTCDI-DAQ@C在1 A g^(-1)下循环10,000次后仍能保持155 mA h g^(-1)的优异放电容量.在使用Na_(3)Bi为负极的全电池中,NTCDI-DAQ@C可以提供高达245 mA h g^(-1)cathode的峰值放电容量,且在0.1 A g^(-1)下循环200次后仍保持了223 mA h g^(-1)的超稳定容量.据我们所知,NTCDI-DAQ@C是SIBs中最好的小分子有机正极之一,NTCDI-DAQ@C//Na_(3)Bi SIBs的卓越综合性能也可与目前最先进的SIBs相媲美.展开更多
A new organic cathode namely potassium 2,6-dihydroxyanthraquinone(AQ26OK,theoretical capacity(CT)=169 mA h g^(-1))is synthesized and fully characterized for Kion batteries.AQ26OK is called polyanionic organic cathode ...A new organic cathode namely potassium 2,6-dihydroxyanthraquinone(AQ26OK,theoretical capacity(CT)=169 mA h g^(-1))is synthesized and fully characterized for Kion batteries.AQ26OK is called polyanionic organic cathode because it has a polyanionic organic skeleton(-2 valent)and two strong ionic K-O bonds.Consequently,the polyanionic AQ26OK is hardly soluble into most organic liquid electrolytes.In half cells(0.3-3.4 V vs.K^(+)/K)using 1 mol L^(-1) KPF6 in dimethoxyethane,AQ26OK delivers a highly stable specific capacity of 201 mA h g^(-1)@50 mA g^(-1) over 450 cycles(4-month test)and realizes~106 mA h g^(-1) for 3200 cycles at 500 mA g^(-1).Using the reduced state(K4TP)of potassium terephthalate(K2TP)as the organic anode,the resulting K4TP Ⅱ AQ26OK organic potassium-ion batteries can display a highly stable average discharge capacity of 135 mA h g^(-1) cathodeover 250 cycles at 100 mA g^(-1) and~47 mA h g^(-1) for 1000 cycles at 500 mA g^(-1) during the working voltage of 0.01-3.1 V.To the best of our knowledge,AQ26OK is among the best stable cathodes reported for K-ion batteries.展开更多
Indium gallium nitride(InGaN)based blue light-emitting diodes(LEDs)suffer from insufficient crystal quality and serious efficiency droop in large forward current.In this paper,the InGaN-based blue LEDs are grown on sp...Indium gallium nitride(InGaN)based blue light-emitting diodes(LEDs)suffer from insufficient crystal quality and serious efficiency droop in large forward current.In this paper,the InGaN-based blue LEDs are grown on sputtered aluminum nitride(AlN)films to improve the device light power and weaken the efficiency droop.The effects of oxygen flow rate on the sputtering of AlN films on sapphire and device performance of blue LEDs are studied in detail.The mechanism of external quantum efficiency improvement is related to the change of V-pits density in multiple quantum wells.The external quantum efficiency of 66%and 3-V operating voltage are measured at a 40-mA forward current of with the optimal oxygen flow rate of 4 SCCM.展开更多
基金supported by National Natural Science Foundation of China(No.12135015)the Users with Excellence Program of Hefei Science Center,CAS(No.2021HSCUE012)+3 种基金the National Key R&D Program of China(No.2022Y FE03010003)the Major Science and Technology Infrastructure Maintenance and Reconstruction Projects of the Chinese Academy of Sciences 2021the Special Funds for Improving Conditions for Scientific Research in National Scientific Institutions 2022the China Scholarship Council。
文摘At the EAST tokamak, the ion temperature(T_(i)) is observed to be clamped around 1.25 keV in electron cyclotron resonance(ECR)-heated plasmas, even at core electron temperatures up to 10 keV(depending on the ECR heating power and the plasma density). This clamping results from the lack of direct ion heating and high levels of turbulence-driven transport. Turbulent transport analysis shows that trapped electron mode and electron temperature gradient-driven modes are the most unstable modes in the core of ECR-heated H-mode plasmas. Nevertheless, recently it was found that the T_(i)/T_(e)ratio can increase further with the fraction of the neutral beam injection(NBI) power, which leads to a higher core ion temperature(Ti0). In NBI heating-dominant H-mode plasmas, the ion temperature gradient-driven modes become the most unstable modes.Furthermore, a strong and broad internal transport barrier(ITB) can form at the plasma core in high-power NBI-heated H-mode plasmas when the T_(i)/T_(e)ratio approaches ~1, which results in steep core Teand Tiprofiles, as well as a peaked neprofile. Power balance analysis shows a weaker Teprofile stiffness after the formation of ITBs in the core plasma region, where Ticlamping is broken,and the core Tican increase further above 2 keV, which is 80% higher than the value of Ticlamping in ECR-heated plasmas. This finding proposes a possible solution to the problem of Ticlamping on EAST and demonstrates an advanced operational regime with the formation of a strong and broad ITB for future fusion plasmas dominated by electron heating.
基金supported by National Natural Science Foundation of China(No.12075281)the National Magnetic Confinement Fusion Research Program of China(Nos.2017YFE0301104 and 2017YFE0301105)Important Projects of Collaborative Innovation of the Hefei Science Center,CAS(No.2021HSC-CIP007)。
文摘A new multi-band and high-speed endoscope diagnostic for the observation of visible light has been successfully developed on the Experimental Advanced Superconducting Tokamak.The mirror with an aperture is designed at the head of the optical system.Based on two dichroic mirrors,the system is divided into three imaging mirror groups with different bands,i.e.B(380-500 nm),G(500-580 nm)and R(580-750 nm)bands,and its focal length is 16 mm with a relatively large aperture of D/f=1:4.The spatial resolution is less than 5 mm near the object distance of 1750 mm with the camera NAC ACS-1 M60.This optical system will be used to contrastively study both the spatial distribution and time evolution of different impurities in the same field of view.The experimental results confirm that it can be applied to the recognition of plasma boundary and related physical research.
基金National Natural Science Foundation of China(No.81273876).
文摘Objective:To uncover and identify the hot topic and frontier of Chinese medicines treatment of type 2 diabetes mellitus(T2DM).Methods:Web of Science TM was searched for published articles for Chinese medicines treatment of T2DM ranging from January 1st,2002 to July 6th,2016.Knowledge maps of the international Chinese medicines treatment of T2DM are visualized by using document cooccurrence analysis and word frequency analysis(Institution and Journal),co-citation clustering analysis(Co-reference),keyword co-occurrence clustering analysis with CiteSpac III,a tool of scientometrics.Results:Universidad Nacional Autonoma de Mexico is the institution with the highest number of published papers that had been cited in this field,while China has four institutions among the top 10.The journal of the highest frequency of co-cited journal was Diabetes Care,a core one in the field.Keywords co-occurrence network was composed of 185 nodes,541 lines,and divided into 10 clusters.Co-citation network of co-reference was composed of 407 nodes,1199 lines,and divided into 20 clusters.Using Chinese medicine to improve insulin resistance and Chinese medicine research on blood glucose control are the hot topics.The frontier contains two aspects:new drugs development and application of intestinal insulin treatment and development and use of traditional Chinese medicine antidiabetic plants.Conclusion:Institutions from China still plays a major role in TCM-focused T2DM studies.The effect of TCM herbs on insulin resistance is the hot topic of the domain.Developing new TCM herbal medicine that regulates incretin effect is the domain frontier.Research on the Chinese medicines treatment of T2DM needs more high-quality evidence to support,and its mechanism requires further exploration.
基金Project supported by the National Natural Science Foundation of China(Grant No.11471262)Henan University of Technology High-level Talents Fund,China(Grant No.2018BS039)
文摘The fractional Feynman-Kac equations describe the distributions of functionals of non-Brownian motion, or anomalous diffusion, including two types called the forward and backward fractional Feynman-Kac equations, where the nonlocal time-space coupled fractional substantial derivative is involved. This paper focuses on the more widely used backward version. Based on the newly proposed approximation operators for fractional substantial derivative, we establish compact finite difference schemes for the backward fractional Feynman-Kac equation. The proposed difference schemes have the q-th(q = 1, 2, 3, 4) order accuracy in temporal direction and fourth order accuracy in spatial direction, respectively. The numerical stability and convergence in the maximum norm are proved for the first order time discretization scheme by the discrete energy method, where an inner product in complex space is introduced. Finally, extensive numerical experiments are carried out to verify the availability and superiority of the algorithms. Also, simulations of the backward fractional Feynman-Kac equation with Dirac delta function as the initial condition are performed to further confirm the effectiveness of the proposed methods.
基金supported by the National Natural Science Foundation of China(52075394)the National Key R&D Program of China(2022YFB3603603 and 2021YFB3600204)+1 种基金the Key Research and Development Program of Hubei Province(2023BAB137)the Knowledge Innovation Program of Wuhan-Basic Research,the National Youth Talent Support Program,and the Fundamental Research Funds for the Central Universities.
文摘III-nitride materials are of great importance in the development of modern optoelectronics,but they have been limited over years by low light utilization rate and high dislocation densities in heteroepitaxial films grown on foreign substrate with limited refractive index contrast and large lattice mismatches.Here,we demonstrate a paradigm of high-throughput manufacturing bioinspired microstructures on warped substrates by flexible nanoimprint lithography for promoting the light extraction capability.We design a flexible nanoimprinting mold of copolymer and a two-step etching process that enable high-efficiency fabrication of nanoimprinted compound-eye-like Al2O3 microstructure(NCAM)and nanoimprinted compound-eye-like SiO_(2)microstructure(NCSM)template,achieving a 6.4-fold increase in throughput and 25%savings in economic costs over stepper projection lithography.Compared to NCAM template,we find that the NCSM template can not only improve the light extraction capability,but also modulate the morphology of AlN nucleation layer and reduce the formation of misoriented GaN grains on the inclined sidewall of microstructures,which suppresses the dislocations generated during coalescence,resulting in 40%reduction in dislocation density.This study provides a low-cost,high-quality,and high-throughput solution for manufacturing microstructures on warped surfaces of III-nitride optoelectronic devices.
文摘为了解决小分子有机正极在钠离子电池(SIBs)中的溶解问题,我们提出了一种有效的有机电极表面自碳化策略,并制备了新型可溶性小分子有机化合物NTCDI-DAQ对该策略进行验证.通过对惰性气氛下碳化温度和碳化时间的精确控制,在NTCDI-DAQ颗粒表面成功形成了厚度为30-40 nm的碳层,可在不影响NTCDI-DAQ电化学行为的前提下,有效消除其溶解问题.在半电池中,NTCDI-DAQ@C在1 A g^(-1)下循环10,000次后仍能保持155 mA h g^(-1)的优异放电容量.在使用Na_(3)Bi为负极的全电池中,NTCDI-DAQ@C可以提供高达245 mA h g^(-1)cathode的峰值放电容量,且在0.1 A g^(-1)下循环200次后仍保持了223 mA h g^(-1)的超稳定容量.据我们所知,NTCDI-DAQ@C是SIBs中最好的小分子有机正极之一,NTCDI-DAQ@C//Na_(3)Bi SIBs的卓越综合性能也可与目前最先进的SIBs相媲美.
基金supported by the Fundamental Research Funds of University of Electronic Science and Technology of China(UESTC,ZYGX2019J027)the Open Foundation of State Key Laboratory of Electronic Thin Films and Integrated Devices of UESTC(KFJJ201915)Sichuan Science and Technology Program(20YYJC3821)。
文摘A new organic cathode namely potassium 2,6-dihydroxyanthraquinone(AQ26OK,theoretical capacity(CT)=169 mA h g^(-1))is synthesized and fully characterized for Kion batteries.AQ26OK is called polyanionic organic cathode because it has a polyanionic organic skeleton(-2 valent)and two strong ionic K-O bonds.Consequently,the polyanionic AQ26OK is hardly soluble into most organic liquid electrolytes.In half cells(0.3-3.4 V vs.K^(+)/K)using 1 mol L^(-1) KPF6 in dimethoxyethane,AQ26OK delivers a highly stable specific capacity of 201 mA h g^(-1)@50 mA g^(-1) over 450 cycles(4-month test)and realizes~106 mA h g^(-1) for 3200 cycles at 500 mA g^(-1).Using the reduced state(K4TP)of potassium terephthalate(K2TP)as the organic anode,the resulting K4TP Ⅱ AQ26OK organic potassium-ion batteries can display a highly stable average discharge capacity of 135 mA h g^(-1) cathodeover 250 cycles at 100 mA g^(-1) and~47 mA h g^(-1) for 1000 cycles at 500 mA g^(-1) during the working voltage of 0.01-3.1 V.To the best of our knowledge,AQ26OK is among the best stable cathodes reported for K-ion batteries.
基金the National Key Research and Development Program of China(No.2019YFA0708203)the Center of Micro-Fabrication and Characterization(CMFC)of WNLO+2 种基金Chinese Academy of Sciences(No.IIMDKFJJ-17-09)the National Natural Science Foundation of China(Grant Nos.61704062,61774065,and 61704176)the China Postdoctoral Science Foundation(No.2016M602287).
文摘Indium gallium nitride(InGaN)based blue light-emitting diodes(LEDs)suffer from insufficient crystal quality and serious efficiency droop in large forward current.In this paper,the InGaN-based blue LEDs are grown on sputtered aluminum nitride(AlN)films to improve the device light power and weaken the efficiency droop.The effects of oxygen flow rate on the sputtering of AlN films on sapphire and device performance of blue LEDs are studied in detail.The mechanism of external quantum efficiency improvement is related to the change of V-pits density in multiple quantum wells.The external quantum efficiency of 66%and 3-V operating voltage are measured at a 40-mA forward current of with the optimal oxygen flow rate of 4 SCCM.