Lithium cobalt oxide(LCO)is the dominating cathode materials for lithium-ion batteries(LIBs)deployed in consumer electronic devices for its superior volumetric energy density and electrochemical performances.The const...Lithium cobalt oxide(LCO)is the dominating cathode materials for lithium-ion batteries(LIBs)deployed in consumer electronic devices for its superior volumetric energy density and electrochemical performances.The constantly increasing demands of higher energy density urge to develop high-voltage LCO via a variety of strategies.However,the corresponding modification mechanism,especially the influence of the long-and short-range structural transitions at high-voltage on electrochemical performance,is still not well understood and needs further exploration.Based on ss-NMR,in-situ X-ray diffraction,and electrochemical performance results,it is revealed that the H3 to H1-3 phase transition dictates the structural reversibility and stability of LCO,thereby determining the electrochemical performance.The introduction of La and Al ions could postpone the appearance of H1-3 phase and induce various types of local environments to alleviate the volume variation at the atomic level,leading to better reversibility of the H1-3 phase and smaller lattice strain,and significantly improved cycle performance.Such a comprehensive long-range,local,and electronic structure characterization enables an in-depth understanding of the structural evolution of LCO,providing a guiding principle for developing high-voltage LCO for high energy density LIBs.展开更多
[Objectives]This study was conducted to obtain the best formula for alkali-soluble Poria polysaccharide tough biscuits.[Methods]Based on low-gluten flour as the main raw material and alkali-soluble Poria polysaccharid...[Objectives]This study was conducted to obtain the best formula for alkali-soluble Poria polysaccharide tough biscuits.[Methods]Based on low-gluten flour as the main raw material and alkali-soluble Poria polysaccharide,baking soda,salt,butter and sugar as auxiliary materials,single-factor test and orthogonal optimization of the addition amounts of alkali-soluble Poria polysaccharide,salt and white sugar were carried out,and the prepared biscuits were subjected to sensory evaluation to get the best formula.[Results]The optimal process parameters of the alkali-soluble Poria polysaccharide tough biscuits were:alkali-soluble Poria polysaccharide addition amount 12%,salt addition amount 1.5%,white sugar addition amount 14%,and the sensory evaluation score obtained under this condition was 88.7.[Conclusions]The alkali-soluble Poria polysaccharide biscuits prepared according to the best formula had the characteristics of neat shape,uniform thickness,fine internal structure,obvious layers,and crisp,rosy and sweet taste.This study increases the flavor and nutritional value of biscuits,enriches the types of biscuits,and provides a certain theoretical basis for the production of alkali-soluble Poria polysaccharide tough biscuits.展开更多
The lung is one of the most common sites for cancer metastasis.Collagens in the lung provide a permissive microenvironment that supports the colonization and outgrowth of disseminated tumor cells.Therefore,down-regula...The lung is one of the most common sites for cancer metastasis.Collagens in the lung provide a permissive microenvironment that supports the colonization and outgrowth of disseminated tumor cells.Therefore,down-regulating the production of collagens may contribute to the inhibition of lung metastasis.It has been suggested that mi R-29 exhibits effective anti-fibrotic activity by negatively regulating the expression of collagens.Indeed,our clinical lung tumor data shows that mi R-29 a-3 p expression negatively correlates with collagen I expression in lung tumors and positively correlates with patients’outcomes.However,suitable carriers need to be selected to deliver this therapeutic mi RNA to the lungs.In this study,we found that the chemotherapy drug cisplatin facilitated mi R-29 a-3 p accumulation in the exosomes of lung tumor cells,and this type of exosomes exhibited a specific lung-targeting effect and promising collagen down-regulation.To scale up the preparation and simplify the delivery system,we designed a lung-targeting liposomal nanovesicle(by adjusting the molar ratio of DOTAP/cholesterol-mi RNAs to 4:1)to carry mi R-29 a-3 p and mimic the exosomes.This liposomal nanovesicle delivery system significantly down-regulated collagen I secretion by lung fibroblasts in vivo,thus alleviating the establishment of a pro-metastatic environment for circulating lung tumor cells.展开更多
基金funded by the National Natural Science Foundation of China(grant no.21761132030,21935009)National Key Research and Development Program of China(grant no.2016YFB0901502,2018YFB0905400)Collaboration project between Ningde City&Xiamen University(2017c002)。
文摘Lithium cobalt oxide(LCO)is the dominating cathode materials for lithium-ion batteries(LIBs)deployed in consumer electronic devices for its superior volumetric energy density and electrochemical performances.The constantly increasing demands of higher energy density urge to develop high-voltage LCO via a variety of strategies.However,the corresponding modification mechanism,especially the influence of the long-and short-range structural transitions at high-voltage on electrochemical performance,is still not well understood and needs further exploration.Based on ss-NMR,in-situ X-ray diffraction,and electrochemical performance results,it is revealed that the H3 to H1-3 phase transition dictates the structural reversibility and stability of LCO,thereby determining the electrochemical performance.The introduction of La and Al ions could postpone the appearance of H1-3 phase and induce various types of local environments to alleviate the volume variation at the atomic level,leading to better reversibility of the H1-3 phase and smaller lattice strain,and significantly improved cycle performance.Such a comprehensive long-range,local,and electronic structure characterization enables an in-depth understanding of the structural evolution of LCO,providing a guiding principle for developing high-voltage LCO for high energy density LIBs.
基金High-level Cultivation Project of Huanggang Normal University(04201711903)Youth Talent Project of Hubei Provincial Department of Education(03201718402)。
文摘[Objectives]This study was conducted to obtain the best formula for alkali-soluble Poria polysaccharide tough biscuits.[Methods]Based on low-gluten flour as the main raw material and alkali-soluble Poria polysaccharide,baking soda,salt,butter and sugar as auxiliary materials,single-factor test and orthogonal optimization of the addition amounts of alkali-soluble Poria polysaccharide,salt and white sugar were carried out,and the prepared biscuits were subjected to sensory evaluation to get the best formula.[Results]The optimal process parameters of the alkali-soluble Poria polysaccharide tough biscuits were:alkali-soluble Poria polysaccharide addition amount 12%,salt addition amount 1.5%,white sugar addition amount 14%,and the sensory evaluation score obtained under this condition was 88.7.[Conclusions]The alkali-soluble Poria polysaccharide biscuits prepared according to the best formula had the characteristics of neat shape,uniform thickness,fine internal structure,obvious layers,and crisp,rosy and sweet taste.This study increases the flavor and nutritional value of biscuits,enriches the types of biscuits,and provides a certain theoretical basis for the production of alkali-soluble Poria polysaccharide tough biscuits.
基金supported by the National Natural Science Foundation of China(Grant Nos.81630068,31670881,and 81901466)China Postdoctoral Science Foundation(Grant No.2020TQ0282)。
文摘The lung is one of the most common sites for cancer metastasis.Collagens in the lung provide a permissive microenvironment that supports the colonization and outgrowth of disseminated tumor cells.Therefore,down-regulating the production of collagens may contribute to the inhibition of lung metastasis.It has been suggested that mi R-29 exhibits effective anti-fibrotic activity by negatively regulating the expression of collagens.Indeed,our clinical lung tumor data shows that mi R-29 a-3 p expression negatively correlates with collagen I expression in lung tumors and positively correlates with patients’outcomes.However,suitable carriers need to be selected to deliver this therapeutic mi RNA to the lungs.In this study,we found that the chemotherapy drug cisplatin facilitated mi R-29 a-3 p accumulation in the exosomes of lung tumor cells,and this type of exosomes exhibited a specific lung-targeting effect and promising collagen down-regulation.To scale up the preparation and simplify the delivery system,we designed a lung-targeting liposomal nanovesicle(by adjusting the molar ratio of DOTAP/cholesterol-mi RNAs to 4:1)to carry mi R-29 a-3 p and mimic the exosomes.This liposomal nanovesicle delivery system significantly down-regulated collagen I secretion by lung fibroblasts in vivo,thus alleviating the establishment of a pro-metastatic environment for circulating lung tumor cells.